DOI: 10.1055/s-00000131

Synfacts

Issue 11 · Volume 8 · November 2012 DOI: 10.1055/s-002-23947

Synform

A107
Zanda, Matteo: SYNFORM ISSUE 2012/11

Synthesis of Natural Products and Potential Drugs

z1163
All PDFs of this category
1163
Synthesis of (+)-Artemisinin
1164
Second-Generation Synthesis of Sulopenem
1165
Third-Generation Synthesis of Sulopenem
1166
Convergent Total Syntheses of Callipeltosides A, B, and C
1167
Synthesis of (–)-9-epi-Presilphiperfolan-1-ol and (–)-Presilphiperfolan-1-ol
1168
Synthesis of an H3 Antagonist
1169
Synthesis of MK-4256
1170
Synthesis of a Hydroxamic Acid LpxC Inhibitor
1171
Synthesis of (+)-Ponapensin and (+)-Elliptifoline
1172
Synthesis of Methopholine
1173
Total Synthesis of (+)-Marinomycin A
1174
Synthesis of a BACE1 Inhibitor
1175
Synthesis of (–)-Jiadifenin
1176
Synthesis of AM-8553
1177
Second-Generation Synthesis of (–)‑Aplyviolene
1178
Synthesis of an IGF-1R Modulator
1179
Synthesis of Thiazesim

Synthesis of Heterocycles

z1181
All PDFs of this category
1181
Rhodium/Lewis Acid Catalyzed Cascade Synthesis of Tetrahydropyridazines
1182
Heterocycles via Use of 2-Heteroaryl-2-(tetrahydrofuranyliden)acetonitriles
1183
Practical Brønsted Acid Mediated Synthesis of Coumarins from Allenes
1184
Cu-Catalyzed Synthesis of Furoindolines from Tryptophols
1185
Synthesis of Isoindolinones by an Asymmetric Aza-Wacker-type Cyclization
1186
Silver-Catalyzed Heteroannulation Route to 1-Aminoisoquinolines
1187
One-Pot Gold-Catalyzed Synthesis of Azepino[1,2-a]indoles
1188
Cascade Synthesis of 3-Pyrrolines by a Heck–Aza-Michael Reaction
1189
Expedient Route to Complex Alkaloids through Pd(II)-Catalyzed Indole C-2 Alkylation
1190
Synthesis of Iodotriazoles Using in Situ Generated Electrophilic Triiodide
1191
One-Pot Asymmetric Synthesis of 4-Hydroxypyrazolidines from Aldehydes
1192
Direct C-2 Pyridine C–H Olefination

Synthesis of Materials and Unnatural Products

z1193
All PDFs of this category
1193
Efficient, Non-Toxic Polylactide Synthesis
1194
Synthesis of New Ladder Diboroles
1195
Ketenimine Intermediates in the Pot
1196
Cycloparaphenylenes by the Gram
1197
Iterative Synthesis of Polyynes
1198
Gram-Scale Synthesis of an Antiaromatic Porphyrinoid
1199
Naphthalenes by Microwave-Assisted Dehydrogenative Diels–Alder Reaction
1200
Tetrathiafulvalene-Based Microporous Metal-Organic Framework
1201
One-Step Access to Luminescent Pentaaryldiazaboroles
1202
From Masked Diazonium Salts to Boronic Esters
1203
Controlled Radical Polymerization by Turning on the Lights
1204
Fusing π-Conjugated Heterocycles
1205
Mechanical Stress Yields HCl

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

z1207
All PDFs of this category
1207
Asymmetric Conjugate Addition of Phosphines to Ene-Imines
1208
Cu-Catalyzed Asymmetric Cyclopropanation of 1,2-Disubstituted Alkenes
1209
Iridium-Catalyzed Enantioconvergent Thioetherification
1210
Rhodium-Catalyzed Enantioselective Nucleophilic Allylation of Imines
1211
Dehydrogenative Heck Reaction Using Rh(III)
1212
Platinum-Catalyzed Hydrative Cycloisomerization
1213
Iridium-Catalyzed Asymmetric Hydrogenation of α-Substituted Acrylic Acids
1214
Asymmetric Epoxidation of Conjugated Olefins with Dioxygen
1215
Enantioselective Synthesis of Tertiary α-Hydroxyketones
1216
Diastereoselective Cyclohexyl- and Tetrahydropyranyl Syntheses by Nickel Catalysis
1217
Asymmetric Pyrrolidine Synthesis by [3+2] Cycloaddition of α-Silylimines
1218
All-Carbon Macrocycles by Catalytic Gosteli–Claisen Rearrangement
1219
Asymmetric Epoxidation with an Iron–Porphyrin-like Complex
1220
Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of Ketones
1221
Ruthenium NHC-Catalyzed Z- and Enantioselective Cross-Metathesis
1222
C–H Activation and E-Double Bond Formation by Ruthenium Catalysis
1223
Asymmetric ipso-Friedel–Crafts Alkylation for Quaternary Spirocenters
1224
Iridium-Catalyzed Enantioselective Hydrogenation of Sulfones
1225
Oxazaborolidinium Ion Catalyzed Asymmetric Roskamp Reaction
1226
Iridium-Catalyzed Enantioselective Hydrogenation of Isoquinolines
1227
Ir(I)-Catalyzed Asymmetric Hydrogenation of Seven-Membered Cyclic Imines
1228
Synthesis of Chiral 1,1-Diarylethanes by Stereospecific Nickel Catalysis
1229
Ruthenium-Catalyzed Asymmetric Hydrogenation of Imines
1230
Copper-Catalyzed Asymmetric Claisen Rearrangement of Enolphosphonates
1231
Enantioselective Co-Catalysis to Trap Reactive Zwitterionic Intermediates
1232
β,β-Disubstituted Nitroalkene Hydrogenation Using Rhodium
1233
Palladium-Catalyzed Stereoselective Direct Substitution of Allylic Amines
1234
Rhodium(II) Carbenoids for Alkynoate Synthesis
1235
N,N′-Dioxide Scandium Catalyzed Enantioselective Friedel–Crafts Reaction
1236
Asymmetric Ring-Expansion of Isatins

Metal-Mediated Synthesis

z1237
All PDFs of this category
1237
Fe-Catalyzed sp3–sp3 Cross–Coupling
1238
Synthesis of 8-Oxabicyclo[3.2.1]octanes by Cationic Cascade Cyclization
1239
Cu(I)-Catalyzed Addition of Nucleophilic Silicon to Propargylic Derivatives
1240
Enantioselective Ti(III)-Catalyzed Reductive Cyclization of Ketonitriles
1241
Palldium-Catalyzed Synthesis of Dihydrocycloocta[b]indoles from Iodoindoles
1242
Iron-Mediated Hydrofluorination of Unactivated Alkenes
1243
Stereodivergent Synthesis of Tri- and Tetrasubstituted Alkenes
1244
Double Addition of Grignard Reagents to Acyl Cyanhydrins
1245
Fe-Catalyzed Diastereoselective Cross-Coupling of Cyclic Halohydrins
1246
Fluoroform-Derived CuCF3 for Trifluoromethylation of Arylboronic Acids
1247
Functionalized 2-Aryloxetanes by Oxetane-Directed ortho-Lithiation
1248
Copper-Mediated Cyanation of Indoles and 2-Phenylpyridines
1249
Diastereoselective Addition of Arylzinc Reagents to Sugar Aldehydes
1250
Aryl Carbamates and Sulfamates as Reagents in Fe-Catalyzed Couplings
1251
Trifluoromethylation of Propargylic Derivatives Using (Ph3P)3Cu(CF3)

Organo- and Biocatalysis

z1253
All PDFs of this category
1253
Asymmetric Vinylogous Conjugate Additions of γ-Substituted Butenolides
1254
Cinchona Alkaloid-Catalyzed Isomerization of Imines
1255
Organocatalytic Asymmetric Synthesis of Prostaglandin PGF2α
1256
Catalytic Asymmetric Oxyfluorination of Enamides
1257
H-Bond-Directed Trienamine Catalysis
1258
Superbase-Initiated Mannich Reactions of Sulfonylimidates
1259
Primary Amine Catalyzed Enantioselective Friedel–Crafts Alkylation of Enones
1260
NHC-Catalyzed Enantioselective Synthesis of β,γ-Unsaturated α-Fluoroesters
1261
Catalytic Asymmetric Conjugate Addition of Aldehydes to Acrylates

Polymer-Supported Synthesis

z1263
All PDFs of this category
1263
A3-Coupling Reaction with Au@PMO-IL
1264
Asymmetric Amination with a Polymer-Supported Chiral Rhodium Complex
1265
Borylation of N-Adjacent C(sp3)–H Bonds with Silica-TRIP/Rh
1266
A SiO2-Supported Pd–Amine Catalyst for the Tsuji–Trost Reaction
1267
Monolith-Supported Flow Synthesis of 2-Aminopyrimidines
1268
Au NPs-Catalyzed Oxidation of Hydrosilanes to Silanols
1269
A Clay-Supported Cu(II) Catalyst for the One-Pot Synthesis of Aryl Triazoles
1270
Carbonylative Cyclization of Halobenzoic Acids with PS-NHC–Pd
1271
A Silica-Supported Trifluoromethyl Ketone with KHSO5 for Epoxidation
1272
Epoxidation of Olefins with a Peracid Supported on Silica
1273
Annulation of Quinone Monoacetals with Alkenes Using PS-PFBA
1274
Preparation of Aminoimidazopyridines with γ-Fe2O3@SiO2-OSO3H
1275
Chemoselective Hydrogenation of Carbonyls with Ni–Sn/AlOH

Addenda and Errata

1277
Hitosugi, S.; Yamasaki, T.; Isobe, H.: Bottom-up Synthesis of Zigzag Carbon Nanotube Belt Precursors
1278
Williamson, K. S.; Yoon, T. P.: Fe-Catalyzed Oxyamination of Alkenes with N-Sulfonyl Oxaziridines