DOI: 10.1055/s-00000131

Synfacts

Issue 12 · Volume 15 · December 2019 DOI: 10.1055/s-009-44892

Synform

A184
Zanda, Matteo: SYNFORM ISSUE 2019/12

Synthesis of Natural Products and Potential Drugs

z1341
All PDFs of this category
1341
Synthesis of (–)-Epicoccin G and (–)-Rostratin A
1342
Total Synthesis of Preuisolactone A
1343
Synthesis of pan-JAK Inhibitor PF-06263276
1344
Synthesis of Imatinib
1345
Total Synthesis of (+)-Perseanol
1346
Synthesis of Dactolisib
1347
Total Synthesis of (–)-Vinigrol
1348
Synthesis of JAK3 Covalent Inhibitor PF-06651600
1349
Total Syntheses of Corydalis Alkaloids
1350
Synthesis of (–)-Caldaphnidine O
1351
Synthesis of Tulrampator
1352
Synthesis of GDC-0276 by a Highly Regioselective SNAr Reaction
1353
Synthesis of (±)-Modhephene

Synthesis of Heterocycles

z1355
All PDFs of this category
1355
Divergent Formation of Flavones or Benzofurans from a Common Tyrosine-Based Oxa-Michael Precursor
1356
Synthesis of Bis(pyrroloquinoline) Derivatives from Isatins and β-Keto Amides
1357
Synthesis of Tetracyclic Dihydroquinolinones by a Knoevenagel/Hetero-Diels–Alder Reaction
1358
Conversion of N-Sulfonyl Triazoles into Triazole-Fused Isoindolines
1359
Preparation of Thietane, Thiolane, and Thiane Perfluorinated Diels–Alder Products
1360
Rhodium(II)-Catalyzed Synthesis of Indoloindolones
1361
Decarboxylative Cross-Coupling of Aryls and Hetaryls
1362
Cobalt(II)-Catalyzed Synthesis of Perfluoroalkyl Isoxazoles
1363
Selective Synthesis of Thio-Substituted Cyclotriphosphazene Derivatives
1364
Stereoselective Synthesis of α- and β-l-Rhamnopyranosides
1365
Isoquinolinediones and Isocoumarins by Rhodium(III)-Catalyzed C–H Activation of N-Tosylbenzamides
1366
Synthesis of Di- and Trisubstituted Imidazoles from Methyl Ketones and Aldehydes

Synthesis of Materials and Unnatural Products

z1367
All PDFs of this category
1367
What Can’t You Do with Triptycenes? Boratriptycenes Take Lewis Acids to the Extreme
1368
A Twist to Make Sterically Hindered Aryl Ketones
1369
Cross-Coupling to Create an Aromatic Heptagon
1370
Coming Full Circle With ‘Super-Benzene’
1371
Scalable Synthesis of Nanographenes
1372
Borazatruxenes: A New Class of Moisture-Stable Arene–Borazine Hybrids
1373
Synthesis of Chiral Triptycenes Containing Hexa-peri-hexabenzocoronene Units
1374
Sky-Blue Sky: 2,6-Connected Azulene-Based Polymers Exhibiting Reversible Protonation and High Conductivity
1375
Sweet Inhibition of Zika and Dengue via [60]Fullero-Dendrimers
1376
Synthesis of a Precursor of [16]Cyclophenacene
1377
Alumina Activates Like No Other
1378
MIDA Might’ve Learned a New Trick: Heterocycle Derivatization Using Carboxyboronates

Metals in Synthesis

z1379
All PDFs of this category
1379
Nickel-Catalyzed Enantioselective Hydroamination of Branched 1,3-Dienes
1380
Oxychlorination of Styrenes
1381
Preparation of Chiral Hydrazines
1382
Synthesis of α,α’-Substituted Cyclic Ketones via Electrophilic Deborylation
1383
Steric-Controlled para-C–H Borylation of Common Arene Building Blocks
1384
Tunable Palladium-Catalyzed Difluorocarbene Transfer to Arylboronic Acids
1385
One-Pot Miyaura Borylation/Hayashi–Miyaura Conjugate Arylation Sequence
1386
Carbonylation and Olefination of Alcohols
1387
Three-Component Alkene Carboamination
1388
Palladium-Catalyzed Cross-Couplings of Chiral Alkylzinc Reagents
1389
Rhodium-Catalyzed Kinetic Resolution of Chiral Cyclobutanones
1390
Enantioselective Arylboroxines to Unprotected Imines
1391
Catalytic Site-Selective C–H Oxygenation of Arenes
1392
Atroposelective Synthesis of Biaryl Compounds via Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling
1393
Asymmetric Copper(I)-Catalyzed Imido-Ylide [3+1] Cycloaddition Using Metallo-Enolcarbenes
1394
Palladium-Catalyzed Synthesis of Borylated Cyclopropanes
1395
A New Precatalyst for Highly Efficient Negishi Cross-Coupling Reactions
1396
Regio- and Enantioselective Synthesis of Chiral Allylic Sulfones
1397
Aryl Nickelation of Alkynes to Access Functionalized Benzofurans
1398
Copper-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides and β-Fluoroalkyl Vinylsulfones
1399
Asymmetric Addition of Allenes to Aldehydes
1400
A New Nickel-Catalyzed Reduction of Carboxylic Acids
1401
Photocatalyzed pinacol-type coupling of carbonyls
1402
Copper-Catalyzed Synthesis of Tertiary Homoallylic Alcohols
1403
1,3-Diene Difunctionalization: Copper-Catalyzed 1,2-Amino Oxygenation
1404
Zinc-Mediated Synthesis of trans-2-Substituted Cyclopropylamines
1405
Ruthenium-Catalyzed Formal anti-Hydroboration of Terminal Alkynes
1406
Nickel-Catalyzed Difunctionalization of Alkenes Employing Unstabilized Enolates
1407
Classic Oxidation of Alcohols Using Pyridinium Chlorochromate

Polymer-Supported Synthesis

z1409
All PDFs of this category
1409
Ring Expansion of 2-Alkynyl-1,2-Dihydropyridines with Pyridine N-Oxide on a Silica-Supported Au Complex
1410
Carboxylation of Benzyl Halides with CO2 under UV Irradiation Catalyzed by a Cu–TiO2/MOF Composite
1411
Photocatalytic Oxidative Esterification of Alcohols with N-Hydroxyimides on N-Doped Titania
1412
Hydrogenative Cross-Coupling of Nitriles with Amines on Alumina-Supported Nickel Nanoparticles
1413
Carboxylative Cyclization of Propargylic Amines Catalyzed by Dendrimer-Encapsulated Gold NPs
1414
One-Pot Synthesis of 1,4-Disubstituted β-Hydroxy-1,2,3-Triazoles Catalyzed by CoFe2O4/Cu(OH)2 in H2O
1415
Oxidative Lactonization of Diols with Oxygen in H2O by Using Pt/C
1416
1,3-Bis(carboxymethyl)imidazolium Chloride-Catalyzed Synthesis of Quinolines
1417
Synthesis of Xanthene Derivatives on Montmorillonite-Supported Copper-Layered Nickel Ferrite
1418
Reductive Amination of Aldehydes with Nitroarenes by Molybdenum Disulfide Catalysts
1419
Palladium Nanoparticles Catalyzed Alkylation of 2-Alkylazaarenes with Activated Carbonyl Compounds
1420
Cycloaddition Reaction of Epoxides or Aziridines with Carbon Dioxide on Metalated Cluster Porphyrins
1421
Cobalt-Catalyzed Hydrogenation of Olefins in Water
1422
Olefin Metathesis Catalyzed by a Ruthenium Complex Immobilized on a Chromium–Organic Framework

Organo- and Biocatalysis

z1423
All PDFs of this category
1423
Cinchona Primary Amine-Catalyzed Asymmetric Epoxidation Towards Dithiodiketopiperazines
1424
A Multifunctional Dimeric Organocatalyst Enables Efficient Peptide Bond Formation
1425
Hydrazine-Catalyzed Ring-Closing Carbonyl–Olefin Metathesis for the Synthesis of 2H-Chromenes
1426
Amine-Catalyzed Enantioselective Synthesis of Cyclic β-Amino Aldehydes
1427
Bringing the Inert Si–Si Bond Back to Life: Disilylation of Nonactivated Olefins with Hexamethyldisilane
1428
Construction of Quaternary Carbon Centers by Lewis Acid Catalyzed Transfer Hydromethallylation
1429
Utilization of a Phosphetane Oxide for Catalytic Wittig-Reactions
1430
Organocatalysis Meets Hydrogen Storage: Efficient Dehydrogenation of Ammonia-Borane
1431
Combining Photoredox and Biocatalysis for a General Enantioselective Benzylic Hydroxylation
1432
Carbonyl Catalysis: Acetaldehyde-Catalyzed Synthesis of Oxamide by Hydrolysis of Cyanogen

Chemistry in Medicine and Biology

z1433
All PDFs of this category
1433
Bifunctional Ligands of K-Ras Prevent the Recruitment of BRAF in vitro
1434
Labeling of Tetrazines with Spatiotemporal Precision
1435
Click Chemistry for the Synthesis of Azides
1436
Agnostic Screening of Sulfonyl Fluoride Fragments to Generate Selective Covalent Inhibitors
1437
Photocontrol of a Membrane Nanopore Forming Protein
1438
Synthesis of Nucleoside Oligophosphates: Quick and Not Dirty
1439
Chemical Microbiology and Synthesis Reveals the Structure of Colibactin and its Mode of Genotoxicity
1440
Merging Indole and Morphan Fragments to Form Potent Glucose Transporter Inhibitors
1441
Functionalization and Post-Translational Modification of Cysteines by Tsuji–Trost Reaction
1442
Versatile One-Step Approach to Caged Fluorophores
1443
Torgov Cyclization

Peptide Chemistry

z1445
All PDFs of this category
1445
Design of an Organocatalyst for Peptide Synthesis
1446
Stereodivergent Synthesis of α-Amino Acids by Palladium and Copper Catalysis
1447
Chemical Ligation of Ketoxime Peptides Derived from N-Aryl Peptides and Alkoxyamines
1448
Synthesis of Dehydroamino Acids through Stereospecific Elimination
1449
One-Pot Chemical Synthesis of Proteins by Copper-Mediated Selenazolidine Deprotection
1450
Enzymatic Coupling of Nitroalkanes with Serine
1451
A Straightforward Route to Various N-Trifluoromethylated Compounds
1452
Synthesis of γ-Amino Acid Derivatives from Cyclopropanes with a Chiral Heterobimetallic Catalyst
1453
Nickel-Catalyzed Deaminative Coupling of Pyridinium Salts Derived from Amino Acids
1454
Picolinamide-Directed Palladium-Catalyzed Arylation of Nonactivated C(sp3)–H Bonds
1455
Synthesis of γ-Amino Acid Derivatives through a Radical Process
1456
Metal-Free Three-Component Synthesis of β-Lactams

Flow Chemistry

z1457
All PDFs of this category
1457
Automation of Flow Syntheses by AI Synthetic Route Design and Implementation
1458
[2+2] Cycloaddition of C60 with Allene Derived from Benzil and Methyl Propiolate
1459
Carbonyl-Olefin Metathesis of Ketones and Vinyl Ethers
1460
Flow Rhodoelectro-Catalyzed Alkyne Annulations
1461
Continuous Flow Synthesis of Pyrazoles
1462
Synthesis of TAK-071 Using Flash Chemistry