DOI: 10.1055/s-00000131

Synfacts

Issue 01 · Volume 16 · January 2020 DOI: 10.1055/s-010-47171

Synform

A1
Zanda, Matteo: SYNFORM ISSUE 2020/01

Synthesis of Natural Products and Potential Drugs

z0001
All PDFs of this category
0001
Synthesis of (+)-[5]-Ladderanoic Acid
0002
Synthesis of Tyclopyrazoflor
0003
Synthesis of Allosteric Inhibitor BMS-986165
0004
Total Synthesis of (+)-Vallesamidine
0005
Total Synthesis of (–)-Bilobalide
0006
Total Synthesis of (±)-Talatisamine
0007
Synthesis of (–)-Perezoperezone
0008
Synthesis of (–)-Rubriflordilactone B and (–)-pseudo-Rubriflordilactone B
0009
Synthesis of Halauxifen Methyl
0010
Synthesis of a Fungicidal Pyrimidine Derivative
0011
Total Synthesis of (±)-Myrocin C

Synthesis of Heterocycles

z0013
All PDFs of this category
0013
Asymmetric Synthesis of Indolines via a Transient Chiral Directing Group Intermediate
0014
[3+2] Cycloadditions of 3-Nitroindoles with Substituted γ-Allenoates
0015
Rongalite-Catalyzed Synthesis of Polysubstituted Pyrazoles
0016
Protecting Group Controlled Regiodivergent Syntheses of N-Bridged Heterocycles
0017
Asymmetric Synthesis of γ- and δ-Lactone-Fused Tetralin Derivatives
0018
Oxepinocoumarins by Ring-Closing Metathesis
0019
First Synthesis of a Monocyclic Aromatic 1,2,3,5-Tetrazine
0020
Multicomponent Mannich Reaction through C–H Activation of Azabiaryls
0021
Synthesis of Cyclic Sulfoximines through 5-endo-dig Cyclization of N-Propargylsulfinamides
0022
Synthesis of Fluoroalkylated Isoxazoles from Ynones
0023
One-Step Syntheses of Morpholinones and 1,4-Oxazepane-3-ones
0024
Biocatalytic Asymmetric Synthesis of N-Arylated β-Amino Acids and Pyrazolidinones
0025
Synthesis of Pyridone-Fused Phenanthridines through Multistep Radical Addition/Cyclization Reactions

Synthesis of Materials and Unnatural Products

z0027
All PDFs of this category
0027
Lock It Up: Put the Radical into the Cage
0028
Propellane Prepares for Take-Off with Asymmetric Silaboration Derivatization
0029
Gold-Catalysis is Golden for Precision Synthesis of Bispentalenes
0030
Synthesis of π-Extended Pyracylene
0031
Tetraborylated Polyaromatics
0032
Silylbenzynes are the Key to Functionalized Triptycenes
0033
Iridafluoranthenes: A New Class of Metalla-Analogues of Polycyclic Aromatic Hydrocarbons
0034
No Turn for the Better with Axially Chiral Arylquinones
0035
Connecting the Dots: Synthesis of Fluorescent Hetero[8]circulene and Quasi-aza[8]circulene Analogues
0036
‘Hot n Cold’ Monodisperse Polymerization
0037
V1, Rotate: [1.1.1]Propellane Prepared to Takeoff
0038
Make Your Favorite Aromatic Molecule an AIE Luminogen with this Triarylethene Stapler

Metals in Synthesis

z0039
All PDFs of this category
0039
Catalytic Asymmetric Alkenyl C–H Functionalization and [4+1]-Annulation of Acryl Amides and Allenes
0040
ZnCl2-Catalyzed Decarboxylative Pyridylation
0041
Copper-Catalyzed Asymmetric Sonogashira Couplings
0042
Nickel-Catalyzed Domino Heck-Type Reactions, through Methyl Ester Activation
0043
Rhodium-Catalyzed C(sp2)–H Functionalization of Cyclobutenes
0044
Copper-Catalyzed Three-Component Radical Cascade Generating Congested Dihydropyrrolones
0045
Diastereoselective Cobalt-Catalyzed Remote Hydroboration Via a Chain-Walking Mechanism
0046
Nickel-Catalyzed Dynamic-Kinetic Asymmetric Allylation of Secondary Phosphine Oxides
0047
Copper-Catalyzed Enantioselective Borylallylation of Alkynes
0048
Iron-Catalyzed Imine Formation via Nitrene Transfer
0049
Nickel-Catalyzed Amide Cross-Couplings
0050
Nickel-Catalyzed Enantioselective Reductive Aryl Fluoroalkenylation
0051
Photoredox-Catalyzed Decarboxylative Alkylation of N-Heteroarenes
0052
Gold-Catalyzed Synthesis of α-Allylbutenolides
0053
Preparation of Vinylsilanes
0054
Preparation of Arylated 1,2,3-Triazoles
0055
Dealkenylative Thiylation
0056
Palladium-Catalyzed Nitrile-Assisted C(sp3)–Cl Reductive Elimination via a Domino Heck Process
0057
Diamine Synthesis via a Diastereoselective Aminoalkylation of Aldehydes
0058
CuH-Catalyzed Reductive Coupling Reactions between Aldehydes and Unactivated 1,3-Diene Pronucleophiles
0059
Ion-Pair-Directed Iridium-Catalyzed para-Selective C–H Borylation
0060
Regiodivergent Hydroboration of 1,3-Diynes
0061
Preparation of Substituted 2-Pyrones
0062
Copper-Catalyzed Divergent Synthesis of Polycyclic Pyrroles via Diyne Cyclization
0063
Copper-Catalyzed Aminohalogenation and Aminoazidation of Unactivated Alkenes
0064
Copper-Catalyzed Synthesis of Indolines via Enantioselective Borylative Cyclization
0065
Copper-Catalyzed Azide–Alkyne Cycloaddition (CuAAC)
0066
1,1-Arylalkylation of Alkynes Using Copper-Catalysis

Polymer-Supported Synthesis

z0067
All PDFs of this category
0067
Hydrogenation of Nitroarenes and Acetophenones on Nitrogen-Doped Reduced Graphene
0068
Coupling Reactions of Pyrimidin-2-yl Sulfonates on a Palygorskite-Supported Palladium Complex
0069
Synthesis of 2,4,6-Trisubstituted Pyridines Catalyzed by a Merrifield Resin Supported Quinone
0070
CoNiFe Hydrotalcite Catalyzed Aerobic Oxidative C–H Phosphonation of Tetrahydroisoquinolines
0071
Pd Nanoparticle Catalyzed Intramolecular Reductive Heck Reaction for the Synthesis of Indanones
0072
Copper-Catalyzed Quinoline Synthesis and Alkylation of Amines with Alcohols in Water
0073
Silver-Catalyzed Carboxylative Cyclization of Propargylic Alcohols
0074
Syntheses of Carbamates and Ureas by Using a Palladium(II)-Based Magnetic Nanocatalyst
0075
N-Alkylation of Amides with Alcohols Catalyzed by Ni/SiO2–Al2O3
0076
Ruthenium Nanoparticle Catalyzed Dehydrogenation of Primary Amines to Nitriles
0077
Copper Nanoparticle Catalyzed Reductive Coupling Reactions of Terminal Alkynes
0078
Lead Oxide Nanoparticle Catalyzed Synthesis of Arylbenzodioxoloxanthenediones

Organo- and Biocatalysis

z0079
All PDFs of this category
0079
Excited-State Electron Transfer Enables Organocatalytic Deracemization of Ureas
0080
Peptide-Catalyzed Enantioselective Desymmetrization of Pyridines
0081
Enzyme-Catalyzed Asymmetric, Intramolecular C(sp3)–H Amination
0082
NHC-Catalyzed N,O-Acetal Formation from Heteroarenes and Ketones
0083
Asymmetric Synthesis of Chiral Esters by a Catalytic Wolff Rearrangement
0084
Regiocomplementary Chlorination Enabled by Evolved Aliphatic Halogenases
0085
Formal α-Arylation of Ketones Enabled by Vinyl Cation Stabilization
0086
Polyene Cyclizations Through Iminium Ion Activation
0087
Quinone-Mediated Formal α-Umpolung of Aldehydes
0088
Antibodies as Highly Substrate-Selective Catalysts: Choosing the Right Hapten Can Do The Trick

Chemistry in Medicine and Biology

z0089
All PDFs of this category
0089
Total Synthesis of Heliolactone and its Biological Evaluation in Plants
0090
Discovery and Synthesis of Monastrol
0091
To Die or Not to Die – Inhibition of Apoptosis
0092
Influenza Drug Evades Resistance
0093
Hindered Dialkyl Ether Synthesis Electrified
0094
Potent and Metabolically Stable Non-Opioid Analgesics
0095
Improved Fluorogenic Dye-Aptamer Module for Live-Cell RNA-Imaging
0096
Taking KRAS Inhibitors to the Clinic
0097
Bicyclic Sultams Made Easy
0098
Enantiomeric Probe Pairs for Ligandable Proteome Mapping
0099
Structure-Guided Design of ABA Receptor Agonists for the Control of Plant Water Use
0100
A Positive Allosteric Modulator of the Human Dopamine D1 Receptor
0101
A Photosensitive Cyclic Acetal Enables Efficient Photo-release of 1,3-Diol 2-Arachidonoylglycerol

Peptide Chemistry

z0103
All PDFs of this category
0103
Palladium-Catalyzed C–N Bond Formation of Halotryptophans
0104
Phosphinobenzenethiol-Induced Ligation of Amino Acid Thioesters with 2-Azido-N-benzylacetamide
0105
Organocatalytic Synthesis of α-Hydroxy/Keto-β-Amino Acid Analogues
0106
β-Mercaptan-Assisted Chemical Ligation of Lysine-Containing Peptides
0107
Pd-Catalyzed Functionalization of Peptides and Macrocyclization of Biaryl-Bridged Peptides
0108
Palladium-Catalyzed Selective C–H Olefination of Tryptophan Residues in Peptides
0109
Synthesis of γ-Amino Acid Derivatives from Cyclopropanes
0110
Organocatalyzed Halolactonization of Dienoic Acids
0111
Synthesis of γ-Azido Amino Acid Derivatives

Flow Chemistry

z0113
All PDFs of this category
0113
Iron-Catalyzed Cross-Coupling Reaction in Flow
0114
Continuous Process for Manufacturing 5-Bromo-N-(tert-butyl)pyridine-3-sulfonamide
0115
Hydroperfluoroalkylation of Unsaturated Systems in Continuous Flow
0116
Strongly Lewis Acidic MOF Catalysts for Continuous-Flow Reactions
0117
Peptide Coupling with Unprotected Amino Acids in a Micro-Flow Reactor
0118
Benzylic Lithiation of 1,3,4-Oxadiazoles in Batch and Continuous Flow