DOI: 10.1055/s-00000131

Synfacts

Ausgabe 06 · Volume 17 · Juni 2021 DOI: 10.1055/s-011-50925

Synform

A88
SYNFORM ISSUE 2021/06

Synthesis of Natural Products and Potential Drugs

z0597
All PDFs of this category
0597
Total Synthesis of (+)-Alsmaphorazine C
0598
Synthesis of Alogliptin
0599
A Refined ProTide Route to Uprifosbuvir
0600
A Scalable Ring-Closing Metathesis for the Manufacture of AMG 176
0601
Total Synthesis of (–)-Casuarinine H, (+)-Lycoplatyrine B, and (–)-Dihydrohuperzine A
0602
Synthesis of (±)-Psychotriadine
0603
Total Synthesis of (–)-Curcusone Diterpenoids
0604
Synthesis of Remdesivir via Diastereoselective Organocatalyzed Phosphoramidation
0605
Synthesis of BAY 1161116
0606
Synthesis of Abrocitinib
0607
Synthesis of (+)-Ritterazine B
0608
Synthesis of MK-7145
0609
Synthesis of Nemiralisib
0610
Synthesis of the 2-Fluoroadenine Nucleobase of Islatravir
0611
Synthesis of (±)-Gymnomitrol
0612
Collective Synthesis of Cephalotaxus Alkaloids

Synthesis of Heterocycles

z0613
All PDFs of this category
0613
Gold-Catalyzed Synthesis of 2H‑Azirines from Alkynyl N-Sulfinylimines
0614
Visible-Light-Promoted Intramolecular Aminoiodination of Alkynes
0615
Enantioenriched Tetrahydropyridines from Racemic Allyltriflamides through Kinetic Resolution
0616
Synthesis of Triarylethanes by 1,6-Conjugate Addition
0617
Synthesis of Azacycles through a 1,2-Metalate Shift
0618
General Solid-Phase Protocol for Modular Oligonucleotide Synthesis
0619
Multigram Electrosynthesis of Enecarbamates and Related Building Blocks
0620
Indolylcyclopentenes through an Enantioselective Aminopalladation–Heck Reaction
0621
Synthesis of Enantiopure Piperidines by an Asymmetric Aza-Prins Reaction
0622
5-(Trifluoromethyl)pyrazoles by a Regioselective [3+2] Cycloaddition
0623
Trityl-Cation-Initiated Cycloaddition of Benzyl-Substituted Vinylcyclopropanes with Hydrosilanes
0624
Protein-Templated Assembly of Heterodimeric Tryptase Inhibitors
0625
Generation and Regioselective 3,4-Difunctionalization of Pyridynes
0626
Protecting-Group-Free Asymmetric Synthesis of Pyroglutamic Acid Esters
0627
Disaccharide Synthesis through Regioselective O-Glycosylation under Boronic Acid Catalysis

Synthesis of Materials and Unnatural Products

z0629
All PDFs of this category
0629
Short and Sweet: A New Synthetic Route to Acepleiadylene
0630
Twist and Lock: Helicene–Boranil Fluorophores
0631
Lights, Dienophile, Action!
0632
A Distorted Hybrid Corannulene–Dibenzobistetracene
0633
Polyisobutene Oxidation by Ruthenium Catalysis
0634
Unnatural α-Amino Acid Derivative Synthesis
0635
Easy Access to Chiral Siloxanes and Alkoxysilanes
0636
New Azahelicenes by Cross-Coupling
0637
Put a 1,3,5,2,4-Oxadiazadiborinan Ring on It
0638
Unsymmetrical Thiophene-Based [7]Helicenes
0639
Synthesis of Conjugated Polymers by Palladium-Catalyzed Oxidative Aromatic Homocoupling
0640
Synthesis of Poly(Digermene) by Ge=Ge Metathesis

Metals in Synthesis

z0641
All PDFs of this category
0641
Synthesis of Hydrazides by N–N Coupling
0642
Regio- and Enantioselective Copper-Catalyzed Hydrocarboxylation of Allenes
0643
Enantioselective C–H Rutheniation for the Preparation of Tetrahydrocarbazoles and Cyclohepta[b]indoles
0644
Nickel-Catalyzed Cyanation of (Hetero)arenes
0645
Radical 1,2-Additions to Alkenes and Alkynes
0646
Regiodivergent [3+2] and [3+3] Annulations by Cooperative N‑Heterocyclic Carbene/Iridium Catalysis
0647
Synthesis of Axially Chiral Diamines by Atroposelective Transfer Hydrogenation
0648
Three-Component Asymmetric β-Lactam Synthesis via a Cu/Pd-Catalyzed Interrupted Kinugasa Allylic Alkylation
0649
Enantioselective Zinc-Catalyzed Conjugate Addition of Catalytically Generated Homoenolates
0650
Nickel-Catalyzed Alyklborylation via an Alkenylboration Hydrogenation Sequence
0651
Radical Decarboxylative Fluorination of Aromatic Carboxylic Acids
0652
Solid-State Suzuki–Miyaura Cross-Coupling of Insoluble Aryl Halides Using a Ball-Milling Approach
0653
Nickel-Catalyzed Enantioselective α-Alkenylation of N-Sulfonyl Amines
0654
Manganese-Catalyzed Electrooxidative C–H/P–H Cross-Coupling
0655
Synthesis of Bicyclopentane-Containing Chiral Alcohols
0656
Copper-Catalyzed Regioselective Asymmetric Addition of 1,4-Pentadienes to Ketones
0657
Asymmetric Reductive Cross-Coupling of Aryl Iodides with α-Chloroboranes by Nickel/Photoredox Catalysis
0658
Palladium-Catalyzed ortho-C–H Functionalization of Aromatic Ketones for Site-Selective Fluorination
0659
1,2-Metalate Rearrangement of Boronates via Iridium-Catalyzed Allylation
0660
Coupling of Bis(perfluoroalkyl)zinc with Alkynyl Bromides
0661
Stereoselective Synthesis of Tetrasubstituted Monofluoroalkenes from gem-Difluoroalkenes
0662
One-Carbon Homologation of Alkyl Iodides for the Synthesis of gem-Diborylalkanes via Copper Catalysis
0663
Iridium-Catalyzed Enantioselective C–C Coupling of Ethanol with Allylic Acetates
0664
Hydroboration of Alkynes and Alkenes
0665
Preparation of Homoallenyl Alcohols
0666
Asymmetric Photocatalyzed Functionalization of Acrylates
0667
Enantioselective Carbocyanation of Alkenes by Copper/Photoredox Dual Catalysis
0668
ortho-Homoallylation of Aromatic Ketones
0669
Nagata Hydrocyanation: Synthesis of β-Cyanoketones

Polymer-Supported Synthesis

z0671
All PDFs of this category
0671
Photocatalytic Functionalization of Alkenes with a Metal–Organic Layer Containing Eosin Y and Iron
0672
Continuous-Flow Asymmetric Aldol Reaction with a Polystyrene-Supported Prolinamide Organocatalyst
0673
The Suzuki–Miyaura Coupling on Magnesium Organosilicate-Supported Palladium Nanoparticles
0674
Decarboxylation and Decarboxylative Arylation of Carboxylic Acid on Boron Carbon Nitrides
0675
Synthesis of Anilines from Cyclohexanes and Ammonium Acetate with a Pd/C–Ethylene System
0676
Palladium-Free Suzuki–Miyaura Coupling with a Bismuth-Based Composite Photocatalyst
0677
Stabilized-Iridium-Nanoparticle-Catalyzed Cross-β-Alkylation of Primary Alcohols
0678
Synthesis of α-Diketones with a Bifunctional Iron Nanocomposite Catalyst
0679
C−H Arylation of Heteroarenes by Ni(II) Supported on a Bipyridine-Containing Porous Macroligand
0680
Synthesis of 3,4-Dihydropyrimidinones with a Magnetite Nanoparticle-Immobilized Acidic Ionic Liquid
0681
Mizoroki–Heck Reaction in Water Catalyzed by Pd(t-Bu3P)2-Containing Nanoparticles Derived from FeCl3

Organo- and Biocatalysis

z0683
All PDFs of this category
0683
Enantioselective Minisci-Reaction of N-Heterocycles and Amides through Hydrogen-Atom Transfer
0684
Chiral Phosphoric Acid-Catalyzed Desymmetrization of 1,3-Diones by Using Arylhydrazines
0685
Pyrimidopteridine-Catalyzed Photoredox Olefin Hydroamination
0686
Highly para-Selective Hydroarylation of Phenols with 1,3-Dienes
0687
β-Functionalization of Saturated Aza-Heterocycles: A Two-Step Organic Photoredox Catalysis Approach
0688
Photoredox-Catalyzed Redox-Neutral Synthesis of Densely Functionalized Pyrroles
0689
Peptide-Catalyzed Regioselective Acylation of Carbohydrates
0690
Rational Site-Directed Mutagenesis of a Diels–Alderase Permits Reversal of Diastereoselectivity
0691
NHC-Catalyzed Asymmetric Stetter-Aldol-Sequence Grants Access to Axially Chiral N-Aryl Succinimides
0692
Lewis Base-Catalyzed Thioarylation of Cinnamyl Amines with Phenols

Chemistry in Medicine and Biology

z0693
All PDFs of this category
0693
Seven-Step Synthesis of (–)-Colchicine
0694
Better Photoswitch, Better Photopharmacology
0695
Shocking Selectivity for Hsp90α
0696
Concise Synthesis of the Novel Spliceosome Inhibitor H3B-8800
0697
A Blood-Brain Barrier Penetrant Photooxygenation Catalyst for Aβ Degradation
0698
A Novel APJ Receptor Agonist through SAR Studies
0699
Photocaged Antibiotics
0700
Uncaging Ligands using Bioluminolysis
0701
A Better Version of Rhodamine Voltage Reporter by ‘Trapping‘
0702
Thermal Proteome Profiling Identifies the Target of Indophagolin
0703
Covalent Suppression of the Cellular HDM2/p53 Protein-Protein Interaction using NASA
0704
Late-Stage Radiolabeling Enabled by SuFEx
0705
The Woodwardian Synthesis of Erythromycin A

Peptide Chemistry

z0707
All PDFs of this category
0707
Manganese-Catalyzed Late-Stage Functionalization of Peptides
0708
Iodine-Catalyzed Oxidative 2-Selenylation of Tryptophans
0709
Synthesis of β2-Amino Acid Derivatives by Aminomethylation of Arylacetic Acid Esters
0710
Tetrabutylammonium Decatungstate-Catalyzed Synthesis of γ-Carbonyl α-Amino Acids
0711
Photoredox-Catalyzed Radical Addition to Glyoxylate-Derived N-Sulfinyl Imines
0712
Phospha-Michael Addition to Access β-Phosphorus-Containing α-Amino Acids
0713
Phosphate-Reagent-Mediated Peptide Coupling Reactions
0714
N-Arylation of Amino Acids without Using Transition Metal Catalysts

Flow Chemistry

z0715
All PDFs of this category
0715
Synthesis of [1.1.1]Propellane and Subsequent Functionalization in Continuous-Flow Processes
0716
Synthesis of Indolo[2,1-a]isoquinoline Derivatives under Visible-Light Irradiation in Flow
0717
Superacid and Flow Chemistry Approach towards Ferrier Rearrangement
0718
Synthesis of Glyoxal Derivatives in Continuous Flow
0719
Electrochemical Aza-Wacker Cyclization in Flow