DOI: 10.1055/s-00000131

Synfacts

Issue 07 · Volume 17 · July 2021 DOI: 10.1055/s-011-51189

Synform

A105
Zanda, Matteo: SYNFORM ISSUE 2021/07

Synthesis of Natural Products and Potential Drugs

z0721
All PDFs of this category
0721
Synthesis of (+)-Manginoid A and (–)-Manginoid C
0722
Synthesis of Sisunatovir
0723
Synthesis of β-Secretase Inhibitor NB-360
0724
Synthesis of 9,11-Secosteroids (+)-Pinnigorgiol B and (–)-Pinnigorgiol E
0725
Total Synthesis of (+)-Alstilobanine C, (+)-Undulifoline, and (−)-Alpneumine H
0726
Formal Synthesis of BMT-362265
0727
Synthesis of Tacalcitol
0728
Synthesis of (–)-Koumimine
0729
Total Synthesis of Perovskones and Hydrangenone
0730
Synthesis of AG-270
0731
Synthesis of P2X7 Receptor Antagonist Lu AF27139
0732
Synthesis of Emitasvir
0733
Synthesis of BPR1K871
0734
Formal Synthesis of Telmisartan
0735
Synthesis of Encequidar
0736
Total Synthesis of (±)-Dehydroxypycnidione
0737
Total Synthesis of (±)-Desacetylcolchicine and Formal Synthesis of (±)-Colchicine

Synthesis of Heterocycles

z0739
All PDFs of this category
0739
One-Pot Stepwise Synthesis of γ-Lactams through Cycloadditions with Ketenes
0740
Palladium-Catalyzed Synthesis of Benzoxepines from Vinyl-Substituted Cyclopropanes and Salicylaldehydes
0741
Mild Regioselective Reduction of Pyridines to Dihydropyridines
0742
Rhenium-Mediated Synthesis of Five- and Six-Membered Nitrogen-Containing Heterocycles
0743
Sequential Palladium-Catalyzed Synthesis of Benzosultams
0744
Regioselective Synthesis of Indoles form Azoarenes or Azoxyarenes with Ketones
0745
Copper-Catalyzed Synthesis of Quinazolines and 1,2,4-Oxadiazoles
0746
Iridium-Photocatalyzed Synthesis of Bioactive Tetracyclic Nitrogen-Containing Products
0747
2-Pyridones from Enamides through Ni–Al Bimetallic Catalysis
0748
Synthesis of Functionalized Benzimidazoles through C(sp3)–H Amination/C–N Bond Cleavage
0749
Palladium-Catalyzed Synthesis of Enantiopure Eight-Membered Nitrogen Heterocycles
0750
One-Pot Construction of 2,3-Dialkyl-Substituted Quinazolinones from Secondary Amides and Isocyanate
0751
Iridium-Catalyzed Approach to Polycyclic Nitrogen-Containing Systems
0752
Selectfluor-Promoted Synthesis of Functionalized Isothiazolones

Synthesis of Materials and Unnatural Products

z0753
All PDFs of this category
0753
Powerful Rotamers for Asymmetric Synthesis
0754
Inserting a Seventh Carbon into Perylene Bisimide
0755
Site-Selective Electrophilic Substitution of 9-Substituted Triptycenes
0756
Accessing Useful Quantities of CPP
0757
Carbons by the Barrel
0758
Efficient Six-Step Synthesis of peri-Heptacene
0759
Synthesis of β-Isoindigo Derivatives
0760
Elegant Ring Formation Aided by Iron
0761
One Step to Spiro Nation
0762
Selective Synthesis of Cyclo[9]pyrroles
0763
Falling into Place: Facile Access to Modular 2,6-Dicyanoanilines
0764
Silicon on the Run in a Gold-Catalyzed Cycloisomerization

Metals in Synthesis

z0765
All PDFs of this category
0765
Nickel-Mediated C(sp3)–H Methylation via Photochemical Activation of Peroxides
0766
Switchable Selectivity in the Asymmetric Rhodium-Catalyzed Hydrothiolation of Cyclopropenes
0767
Ruthenium-Catalyzed Enantioselective Reductive Amination
0768
NiH-Catalyzed Hydroamidation of Alkynes with Dioxazolones
0769
Nickel-Catalyzed Site-Selective Heteroarylation of Cyclobutanols
0770
Synthesis of Indoles from N-Benzoyloxyallylamines and Iodoarenes by Palladium/Norbornene Catalysis
0771
Synthesis of Chiral Sulfones by Three-Component Radical Reaction
0772
Photocatalyzed Decarboxylation of Carboxylic Acids
0773
Iron-Catalyzed Oxidation of Olefins
0774
Alkylation and Alkenylation of Neopentylamine
0775
δ-Fluorination of N-Alkyl Sulfonamides
0776
Fluoroalkylative Reductive Coupling of Alkyl Bromides
0777
Dioxazolones as Nitrene Precursors under Iron Catalysis
0778
Photoredox and Nickel-Catalyzed Aminoarylation
0779
Preparation of Functionalized 1,3-Disbustituted BCBs
0780
Visible-Light Assisted Sulfonylation of (Hetero)Aryl Halides
0781
Dual-Ligand-Enabled Ruthenium-Catalyzed C–H Arylation of Buchwald Phosphine Ligands
0782
Manganese-Catalyzed Hydroboration of Unsaturated C=X Bonds
0783
Asymmetric, Light-Mediated Radical Sulfinyl-Smiles Rearrangement
0784
ortho-C–H Imidation of Benzaldehydes using a Transient Directing Group
0785
Nickel-Catalyzed Aldol Reactions
0786
Preparation of Polycyclic Lactams
0787
Asymmetric Synthesis of γ-Lactams by Palladium-Catalyzed Hydroesterificative Cyclization
0788
Synthesis of Nitrogen-Containing Terminal Alkyl Chlorides via Copper-Catalyzed Chloromethylazidation
0789
Synthesis of Fully Substituted Pyrroles from Imino Ethers and Enol Diazoacetates using Silver Catalysis
0790
1,4-Acetoxychlorination of Dienes: The Bäckvall Reaction
0791
Enantioselective Preparation of Propargylsilanes
0792
Incorporation of gem-Difluoroalkene Motifs via Regioselective C(sp3)–H Functionalization

Polymer-Supported Synthesis

z0793
All PDFs of this category
0793
A Polymeric Bipyridyl Nickel Composite for C–H Arylation of Heteroarenes
0794
Suzuki–Miyaura Coupling with a Palladium-Complexed Azo Porous Organic Polymer
0795
Hydroaminomethylation of Alkenes Promoted by Ruthenium on TiO2
0796
Sulfonation of Enamides, Acrylamides, and Enones Photocatalyzed by Single-Atom Nickel on TiO2
0797
C–C Coupling of Nitriles with Arylboronic Acids Catalyzed by Mesoporous Silica-Tethered Platinum
0798
Photocatalytic Oxidative Amidation of Aldehydes with Magnetic Cadmium Sulfide Quantum Dots
0799
Catalytic Esterification of Amides by Using a Zirconium-Based Metal–Organic Framework
0800
Hydrogenation of Carbonyls, Nitriles, and Nitroarenes by Using Ni2P Nanoalloy Catalyst in Water
0801
Protection and Deprotection of Alcohols by Using a Zn Complex Supported on Magnetic Nanoparticles
0802
Tandem Asymmetric Michael/Transfer Hydrogenation by Using a Dual Rh-Incorporated Micelle Reactor

Organo- and Biocatalysis

z0803
All PDFs of this category
0803
Heterofunctionalization of Arenes by Electrophotocatalysis
0804
Biosynthesis of Hirsutellones and Pyrrocidines through an exo-Selective Diels–Alder Cycloaddition
0805
Pyrrolidine Aminocatalytic Asymmetric [12+2] Cycloaddition toward Cycl[3.2.2]azines
0806
Activation of N-Heterocycles by Silylium Catalysis for C–C Bond Formation
0807
Catalytic (3+2) Annulation of Aminocyclopropane Monoesters and Indoles
0808
Organocatalytic, Visible-Light-Mediated Dicarboxylation with Carbon Dioxide via Anion Radicals
0809
Catalytic Asymmetric Stereospecific Substitutions of Racemic α-Aryl Aldehydes
0810
Catalytic Asymmetric α-Chlorination of Aldehydes
0811
Two Work Better Than One: Cooperative NHC and Photoredox Catalysis for Benzylic C–H Bond Acylation

Chemistry in Medicine and Biology

z0813
All PDFs of this category
0813
Spirocyclic Ketone Construction via Semipinacol-Type Rearrangement
0814
Biphenyl Imidazopyridines as a New Scaffold for PD-L1 Inhibitors
0815
Synthesis and Application of the 3-Phosphonofluoresceins
0816
Selective Cannabinoid Type 2 Receptor Antagonists
0817
Watching RNA Do Its Job
0818
Site-Selective LYTACs for Targeted Protein Degradation
0819
Scalable Synthesis of Opioids Enabled by a Palladium-Catalyzed Dearomative Arylation
0820
Small-Molecule Inhibitor of an RNA-Modifying Enzyme for Acute Myeloid Leukemia Treatment
0821
Late-Stage Alkylation of Purine Nucleoside at the C6 Position
0822
Utorubicin: A Novel Anthracycline Cancer Prodrug
0823
Next-Generation Macrolide Antibiotics
0824
Stereostructure–Activity Studies of Spirooliganin

Peptide Chemistry

z0825
All PDFs of this category
0825
Palladium-Catalyzed Olefination of Oxazole-Containing Peptides
0826
Oxidative Peptide Bond Formation of 2-(Aminomethyl)malononitriles
0827
Copper-Catalyzed Synthesis of Bulky Amides and Peptides
0828
Hypervalent-Iodine-Mediated Peptide-Bond Formation to Synthesize Hindered Peptides
0829
Nickel-Catalyzed Synthesis of β-Amino Acid Derivatives
0830
Synthesis of Isoquinolone-Containing Amino Acids by Rhodium-Catalyzed C–H Annulation
0831
Palladium-Catalyzed δ-C(sp3)–H Arylation of Amino Acids
0832
Petasis Reaction for the Synthesis of Unnatural Amino Acids
0833
Synthesis of N-Unprotected α-Amino Acid Methyl Esters
0834
Photoredox-Catalyzed Synthesis of γ-Amino Acid Derivatives

Flow Chemistry

z0835
All PDFs of this category
0835
N-Arylation of Amino Acid Esters using a Pd(OH)2 Packed-Bed Reactor
0836
Bromine–Sodium Exchange and Directed Metalations in Continuous Flow
0837
Synthesis of Fluorinated Tertiary Alcohol Derivatives under Visible-Light Irradiation
0838
Ru-promoted Photooxidative C–H Functionalization of Isoquinolines in a Microflow Reactor
0839
Precise Control of cis−trans Isomerization of α-Anionic Stilbenes under Flow Conditions