DOI: 10.1055/s-00000131

Synfacts

Issue 11 · Volume 17 · November 2021 DOI: 10.1055/s-011-52158

Synform

A174
Zanda, Matteo: SYNFORM ISSUE 2021/11

Synthesis of Natural Products and Potential Drugs

z1175
All PDFs of this category
1175
Total Synthesis of (+)-Clionastatins A and B
1176
Scalable Stereoselective Synthesis of BMT-297376
1177
Synthesis of the Tricyclic Core of BMS-986251
1178
Total Synthesis of (+)-ent-Shagene A and (–)-ent-Shagene B
1179
Total Synthesis of (–)-Kadcoccinic Acid A Trimethyl Ester
1180
Diastereoselective Synthesis of TAK-828F
1181
Gram-Scale Synthesis of Dolutegravir Sodium
1182
Synthesis of (±)-Annotinolides C, D, and E
1183
Synthesis of (−)-Strempeliopine
1184
Synthesis of the Cyclohexane Dicarboxylate Fragment of BMS-986251
1185
Synthesis of Giredestrant
1186
Scalable Synthesis of ELQ-300
1187
Asymmetric Synthesis of AZD8186
1188
Synthesis of BMS-986318
1189
Total Synthesis of Aspidosperma Alkaloids
1190
Concise Synthesis of Molnupiravir
1191
Streamlined Synthesis of Fevipiprant
1192
Formal Synthesis of (R)-Silodosin
1193
Total Synthesis of (±)-Lycopodine

Synthesis of Heterocycles

z1195
All PDFs of this category
1195
Nitrogen Deletion of Secondary Amines
1196
Molecular Editing through Ring Expansion of Pyrroles and Indoles
1197
Multicomponent Approach to Functionalized Pyrazoles
1198
Sustainable Oxidative Rearrangement of Furan Derivatives
1199
Mild Synthesis of Polysubstituted Functionalized Pyrroles
1200
Enantioselective Approach to β-Amino Acid Derivatives
1201
Copper-Catalyzed Synthesis of β-Lactams from Oximes and Methyl Propiolate
1202
Palladium-Catalyzed Approach to Arylquinolin-2(1H)-ones
1203
Direct Synthesis of Functionalized Benzofurans from Phenols
1204
Nonsymmetrical Trisubstituted s-Triazines: A Scalable Synthesis
1205
Synthesis of Tricyclic Indoles by Enantioconvergent Substitution of Alcohols
1206
Gram-Scale Access to Orthogonally Protected (Aza)spiro[2.3]Hexane Diamines

Synthesis of Materials and Unnatural Products

z1207
All PDFs of this category
1207
Unsymmetrical Tetraphenylenes
1208
Tetraphenylene Octaamine
1209
Towards Cubic Graphite
1210
Copper-Catalyzed 3‑Positional Amination of 2‑Azulenols
1211
Thiophene-Fused Porphyrin Dimer and the Geometry Tuned by Central Metal
1212
Greenhouse Gas to Functional Polyester
1213
No Sulfurane, No Helical Gain
1214
Acenoaceneology
1215
Plane of 2,9-Diazadibenzoperylenes
1216
Connecting Two Bowls
1217
New and Blue N+–N– Heterocycles
1218
Planar Chiral B−N Heteroarenes

Metals in Synthesis

z1219
All PDFs of this category
1219
Palladium-Catalyzed Intermolecular 1,1-Carbobromination of Alkenes with Alkynyl Bromides
1220
Synthesis of α-Chiral Ketones by Nickel-Catalyzed Reductive Hydroformylation–Carbonylation
1221
Photoredox-Enabled Deoxygenative Cross-Coupling of Alcohols Activated by NHCs
1222
Catalytic Enantioselective Carbozincation
1223
Radical-Mediated Carbosulfonylation of Propellanes
1224
Preparation of Ynimines
1225
Preparation of contra-Thermodynamic Olefins
1226
Photoinduced Copper Catalysis in an Asymmetric Three-Component Coupling Reaction
1227
Asymmetric Palladium-Catalyzed Allylic C–H Functionalization
1228
α-Deracemization of Pyridylketones by Photoredox Catalysis
1229
Decarboxylative Phenol Synthesis from Carboxylic Acids
1230
Coupling of Trifluoromethylarenes and Boronic Acids
1231
C–O Cross-Coupling of Tertiary Aliphatic Alcohols
1232
Synergistic Dual Catalyzed Aza-[4+2] Cycloaddition of α-Amino Carbonyl Compounds and 1,3-Dienes
1233
Furan Derivatives via Palladium- and Acid-Catalyzed [3+2] Cycloaddition of α‑Aryl-α-diazoacetates
1234
Preparation of (Hetero)Aryl Alkynes from Carboxylic Acids
1235
Chromone Synthesis via Rhodaelectro-Catalyzed Formyl C–H Activation
1236
Alcohol-Directed, Nickel-Catalyzed 1,2-Carboamination of Alkenes
1237
Functionalization of C–H Bonds and Carboxylic Acids via Copper Catalysis
1238
Copper-Mediated Preparation of Sulfones
1239
Methylation of Alkylpyridinium Salts
1240
Photoinduced Copper-Catalyzed Cross-Coupling of Oxime Esters and 1,3-Dienes
1241
Sulfilimines Synthesis from Grignard Reagents and Sulfinimidate Esters
1242
Dual Catalysis with Cobalt and Chiral Phosphoric Acids: Synthesis of Enantioenriched Spiro-γ-lactams
1243
A New Dioxazolone Reagent for the Safe and Facile Installation of Free Amino Groups
1244
Switchable Chemoselectivity Controlled by Metal-to-Ligand Ratio
1245
Copper-Mediated Homologation of Alkynes to Allenes: The Crabbé Reaction
1246
Hydroaminocarbonylation of Alkenes and Alkynes

Polymer-Supported Synthesis

z1247
All PDFs of this category
1247
Photochemical Meerwein Arylation By Using a Titanium(VI)-Based Covalent Organic Framework
1248
Carbonylative Suzuki Cross-Coupling Catalyzed by Pd/Graphitic Carbon Nitride
1249
Synthesis of α-Keto Acids by Iron-Catalyzed Oxidation of Alkenes
1250
Cyclization of Propargylamines with CO2 on Copper-Based Metal–Organic Frameworks
1251
Oxovanadium-Catalyzed Direct Nucleophilic Substitution of Alcohols
1252
Arylation of Amines with Aryl Halides Catalyzed by a Magnetic Cobalt Nanocatalyst
1253
Hydrogenation of Aliphatic Aldehydes and Ketones on Stabilized PtRu or IrRu Bimetallic Nanoparticles
1254
Ligand-Free Copper Nitride-Catalyzed Hydroxylation of Aryl Halides
1255
Enantioselective Passerini Reaction by a Chiral Brønsted Acid Catalyst Supported on Silica Gel
1256
Ambient Hydrogenation of Alkenes and Alkynes Catalyzed by Nickel Nanoparticles on Carbon

Organo- and Biocatalysis

z1257
All PDFs of this category
1257
Catalytic Asymmetric Aldolization of Propanal Enol Silanes
1258
Organocatalytic Site-Selective Functionalization of Azobenzenes
1259
Hydrazine Synthesis by Cross-Selective Reductive Coupling of Nitroarenes and Anilines
1260
N-Heterocyclic Carbene Permits Radical-Mediated Trichloromethylacylation of Vinylarenes
1261
Hydrocarboxylation of Activated Olefins by Photoinduced Thiol Catalysis
1262
Photoinduced Radical Coupling of Aryl Chlorides through Consecutive Photoinduced Electron Transfer
1263
Axial Chirality at the B–C Bond: Atroposelective Functionalization of Aryl-1,2-azaborines
1264
Organophosphorus-Catalyzed Serial Dehydration for Amide Coupling and Activation
1265
Hydrogen Bonding Enables Highly Selective Norrish Type II Ring Contractions
1266
Organocatalytic Enantioselective Dearomatization of Thiophenes by 1,10-Conjugate Addition

Chemistry in Medicine and Biology

z1267
All PDFs of this category
1267
An Asymmetric [3+2] Cycloaddition/Ring-Expansion Sequence Towards Lysergic Acid
1268
Synthesis of Arimetamycin Hybrids
1269
Concise Synthesis of Deoxygenated Sugar
1270
A Photocatalytic Approach towards Cyclopentanonyl-Fused Cyclic Ethers
1271
Handy Thioethers: Biotin-Derived Sulfimides as Protein and DNA Labeling Tools
1272
4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6)
1273
Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H)
1274
Redirection of the Transcription Factor SP1 by Synthetic Molecules
1275
A Chiral Hydrindane Mimics Fatty Acid and Inhibits ToxT
1276
Taking Bicycles on a New Ride
1277
Fine-Tuning of Acid–Base Equilibria on the Synthesis of the Hexacyclic Core of Palau’amine
1278
Freeze! Put your tRNAs up!
1279
The First Total Synthesis of Lysergic Acid

Peptide Chemistry

z1281
All PDFs of this category
1281
Rhodium-Catalyzed α-Tetrasubstituted α-Amino Acid Synthesis
1282
Selenium Solid Support for the Synthesis of AM-Toxin II
1283
Allenone-Mediated Formation of Peptide Bonds
1284
N-Arylation of Imidazole Side Chain of Histidine or Histidine-Containing Peptides
1285
Selective Modification of Peptides through Cleavage of a Secondary Amide Bond
1286
Radical-Coupling Reaction for the Synthesis of γ-Amino Acid Esters
1287
Visible Light-Mediated C–H Amination of Amino Acids or Peptides
1288
Chiral Pyridoxal-Catalyzed Synthesis of β-(Trifluoromethyl)-β-hydroxy-α-amino Acid Derivatives
1289
Visible Light-Mediated Selenium–Sulfur Bond Formation to Afford Selenium–Sulfur Bond-Containing Peptides
1290
Copper-Catalyzed Synthesis of α-Amino Acid Derivatives by C(sp3)–H Alkylation
1291
Nickel-Catalyzed Glycosylation of Amino Acids or Peptides

Flow Chemistry

z1293
All PDFs of this category
1293
Synthesis of 3-(Trifluoromethyl)-3-arylcyclopropenes under Flow Conditions
1294
Photoredox-Catalyzed α-Trifluoromethoxylation of Ketones
1295
Flow Approach to Interrupted Curtius Rearrangement of Proline Derivatives
1296
Copper/Rhodium-Catalyzed Flow Synthesis of Chiral Cyclopropanes
1297
Preparation of 2-Pyrrolidone by Photocatalytic 3-Component Cyclization in Flow