Synfacts

Issue 02 · February 2022

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A20
SYNFORM ISSUE 2022/02 FREE ACCESS

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Synthesis of Natural Products and Potential Drugs
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0115
Total Synthesis of (±)-Phainanoid A FREE ACCESS

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0116
Total Synthesis of (±)-Cephanolide B

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0117
Synthesis of MK-0429

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0118
Synthesis of (±)-Furanether A

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0119
Synthesis of (–)-Bufospirostenin A

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0120
Total Synthesis of Isorosthin L and Isoadenolin I

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0121
Synthesis of an R_P-Guanosine-3′,5′-Cyclic Phosphorothioate Analogue

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0122
Total Synthesis of (+)-Schizozygine

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0123
Synthesis of Corannulene FREE ACCESS

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Synthesis of Heterocycles
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0125
Aziridination of Alkenes via Electrochemically Generated Thianthrenium Salts

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0126
Synthesis of Isoindolinones from Isoxazoles by a Ring-Opening-and-Closing Cascade Reaction

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0127
Synthesis of Complex Guanidines by [4+2]-Cycloaddition Indoles with N-Amidinyliminium Ions

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0128
Palladium/Norbornene Cooperative Difunctionalization of Five-Membered Arenes

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0129
One-Pot Diastereoselective Preparation of N-Alkenyl-2-Pyridones from 2-Halopyridinium Salts and Aldehydes

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0130
Three-Dimensional Five-Membered Nitrogen- and Sulfur-Containing Heterocycles

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0131
Direct C–H Functionalization of Azines by Electrochemical Manganese Catalysis

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0132
Synthesis of Phenanthridinones by a Cascade Reaction under Mechanochemical Conditions

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0133
Synthesis of Cyclobuta-Fused Tetrahydroquinolines

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0134
Bridged Bicyclic Lactone Synthesis by Brønsted Acid-Promoted Formation of O-Acyloxocarbenium Ions

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0135
Dihydroquinazolinones by a Base-Promoted Intermolecular Cyclization

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0136
Acid-Catalyzed Ring Fragmentation to Access Functionalized Pyrroles

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0137
C–H Activation To Form 2-Quinolin-8-ylisoquinolin-1(2H)-one Derivatives

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Synthesis of Materials and Unnatural Products
z0139
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0139
Domino Cross-Scholl Reaction of Tetracene with Molecular Benzene

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0140
Straightforward Access to Cyclopentadienyl Magnesium Bromides

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0141
Easy Access to Dibenzo[a,e]cyclooctene-5,11(6H,12H)-diones

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0142
Featuring Fullerenes and Ferrocenes

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0143
Polyethylene Copolymers Without Ethylene

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0144
Perfectly Balanced Antiaromaticity, As All Things Should Be

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0145
Stitching Together a Silicon Ladder

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0146
Synthesis of Thiazolo-Chlorin and Porphyrin Skeletons

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0147
New Fluorescent BN-PAHs

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0148
Making Conjugated COFs

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0149
One-Step Installation of Boron

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0150
Cascading into Polyurethanes

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Metals in Synthesis
z0151
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0151
Like a Rolling Stone! Mechanochemical Synthesis of Grignard Reagents in Air FREE ACCESS

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0152
Synthesis of C₂-Symmetric Amines via Two Sequential Iridium-Catalyzed Reductive Aminations

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0153
Iridium-Catalyzed Photosensitization of β-Dicarbonyls to Access Medium-Sized Rings FREE ACCESS

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0154
One C Atom Out, Two C Atoms In: Homologation of α-Amino Acids to β-Amino Aldehydes

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0155
Asymmetric C(sp³)–H/C(sp³)–H Umpolung Coupling of N-Allylimine and α-Aryl Ketones

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0156
Nickel/Photoredox Domino Enantioselective Alkyl Arylation

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0157
Iron-Catalyzed Intramolecular C–H Functionalization of Aliphatic Azides

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0158
Classic Pd versus Radical Ni: Suzuki Cross-Coupling with Alkyl Fluorides under Pd and Ni Catalysis

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0159
Nickel-Catalyzed Deoxygenative Arylation of α-Hydroxy Esters

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0160
Accessing Enantioenriched Tetrahydroquinolines via Pd/Co Cooperative Catalysis

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0161
Addition of Halopyridines Across C=C Double Bonds under Photoredox Catalysis

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0162
Kinetic Resolution of 2° Phosphine Oxides Enabled by Palladium-Catalyzed Benzylation

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0163
What the Heck? Bringing a New Dimension to a Well-Known Reaction with Diazo Compounds

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0164
Cu Later Activator: Difluoromethylation of Alkyl Iodides Now Catalytic in Copper!

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0165
Let the Nickel Do It Alone: Cross-Electrophile Coupling of Heteroaryl Chlorides and Aryl Chlorides

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0166
Stereoselective Iron-Catalyzed Synthesis of (E)-Allylboronates from Allylic Alcohols

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0167
Gold but not Old: Gold(I)-Catalyzed [2+2] and Formal (4+2) Cycloaddition of Ynol Ethers with Alkenes

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0168
1,2-Carboamination of Alkenes with Arylboronic Acids and Amines Enabled by Directed Nickel Catalysis

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0169
Pyridine-Pyridone Ligands with Different Bite Angles Enable Divergent Reactivity

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0170
Atroposelective Synthesis of Axially Chiral Binaphthyl Derivatives by Nickel-Catalyzed C–O Bond Activation

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0171
Modular Synthesis of Benzocyclobutanes and Indolines Using Sequential Copper and Palladium Catalysis

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0172
Synthesis of Benzocyclobutenes via Pd(II)-Catalyzed C(sp³)–H Arylation

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0173
Palladium-Catalyzed Carbonylative Coupling of Difluorohalides and Alkyl Boranes

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0174
Enantioselective Synthesis of Spiro-γ-Lactams via Nitrenoid Transfer Protocol

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0175
A Bimetallic Catalyst Enables the Synthesis of 1,5-Disubstituted 1,2,3-Triazoles

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0176
Palladium as a π-Lewis Base Activator of Cyclopentadienones and their Umpolung Reactivity

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0177
Cadmium–Chalcogenide Photocatalytic Selective Trifluoromethylation

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0178
Highly Selective Hydroaminomethylation of Olefins Enabled by Cobalt Catalysis

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0179
The Soai Reaction: The Origin of Asymmetry-Amplifying Autocatalysis FREE ACCESS

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Polymer-Supported Synthesis
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0181
Reductive Electrophilic C–H Alkylation of Quinolines on a Supported Iridium Catalyst

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0182
Oxidation of Arylboronic Acids and Aryl Aldehydes Catalyzed by Isotruxene-Based Porous Polymers

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0183
Dehydrogenative Cross-Phenol Coupling on a Heterogeneous Oxovanadium Catalyst

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0184
Aqueous Suzuki–Miyaura Cross-Coupling on a Self-Supported Nanoporous Palladium–Copper Alloy

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0185
Heterogeneous Copper-Catalyzed Dehalogenative Deuteration of Aryl Bromides with D₂O and CO

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0186
Photoinduced Graphitic Carbon Nitride-Catalyzed C–H Thiocyanation

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0187
Oxidation of Alcohols and Aerobic Oxidative Synthesis of Benzoxazoles on TEMPO-Functionalized FDU-15

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0188
Suzuki–Miyaura Coupling on a Magnetic Silica-Supported Palladium Catalyst

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0189
Redox-Neutral Mitsunobu Reaction on a Polystyrene-Supported Organophosphorus Catalyst

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0190
Heterogeneous Iron-Catalyzed Oxidative Cleavage of 1,2-Diols to Carboxylic Acids or Ketones

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Organo- and Biocatalysis
z0191
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0191
Photoenzymatic Catalysis Paves the Way for the Synthesis of Enantioenriched Tertiary Amines FREE ACCESS

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0192
Organocatalytic Atroposelective N-Acylation for Synthesis of N–N Axially Chiral Compounds

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0193
Visible-Light Photoredox-Catalytic Defluorinative Alkylation of α-Trifluorocarbonyl Compounds

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0194
Chiral Phosphine-Catalyzed Asymmetric Tandem Isomerization/Annulation toward 3-Pyrrolines

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0195
Identification and Characterization of the First Biological Rauhut–Currier Reaction

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0196
Enantioselective Prins Cyclization of Alkenals through Brønsted Acid/Hydrogen-Bond Donor Co-catalysis

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0197
Regiodivergent Furan Synthesis from 1,3-Dicarbonyl Compounds

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0198
Asymmetric Construction of Quaternary Stereocenters by Addition of α-Alkynyl Ketones to Allenamides

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0199
Organophotoredox-Catalytic α-Defluorinative Alkylation of Polyfluorinated Amides and Esters

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Chemistry in Medicine and Biology
z0201
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0201
An Orally Available Clinical Candidate to Treat Covid-19

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0202
Astercins: Sterol-Derived Cholesterol Transport Protein Inhibitors

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0203
Identifying the Long Sought-After Ligand of the Sigma-2 Receptor FREE ACCESS

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0204
C-Ar-Nucleosides by Nickel-Catalyzed Reaction

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0205
Scratching the Surface of MRGPRX

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0206
Photoaffinity Probe Elucidates Mechanism of Action of a COVID-19 Drug Candidate

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0207
Uncaging Antisense Oligonucleotides with Small Molecules

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0208
Synthesis of (–)-Glionitrin A and B

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0209
Carbonyl Transposition Simplifies Synthesis

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0210
Sweet Spot: Seneciobipyrrolidine Analogues on Glucose Homeostasis

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0211
Benzoxaborole Inhibitor of CPSF3 for the Treatment of Visceral Leishmaniasis

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Peptide Chemistry
z0213
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0213
Electrochemical Synthesis of Peptides Mediated by Triphenylphosphine FREE ACCESS

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0214
Visible Light-Driven C–H Ketoalkylation of Glycine Derivatives with Cycloalkyl Peroxides

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0215
Synthesis of Pyrazole-Based α-Amino Acids by Chiral Phosphoric Acid Catalysis

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0216
Copper-Catalyzed Electrophilic Amination of Substituted Isoxazolidin-5-ones to Form β-Amino Acids

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0217
Dynamic Kinetic Resolution to Access α-Amino Acid Esters

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0218
Synthesis of Dehydroalanine Derivatives from Diamino Diacids by a Radical Process

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0219
Synthesis of N^a-Fmoc-Protected Amino Acid Esters and Peptides FREE ACCESS

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0220
Copper-Catalyzed Synthesis of Thioamide Peptides

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Flow Chemistry
z0221
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0221
Synthesis of Azetidinium Salts via Continuous-Flow

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0222
Palladium-Catalyzed Reductive Amination in an Oscillatory Plug-Flow Reactor

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0223
Leucinol-Catalyzed Asymmetric Aldol Reaction of Isatin and Acetone in Flow

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0224
Electrochemical C–H Bond Activation under Flow Conditions

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0225
Selective Heterogeneous Catalytic Hydrogenation of Nitriles in a Flow System

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