DOI: 10.1055/s-00000131

Synfacts

Issue 02 · Volume 18 · February 2022 DOI: 10.1055/s-012-52704

Synform

A20
SYNFORM ISSUE 2022/02

Synthesis of Natural Products and Potential Drugs

z0115
All PDFs of this category
0115
Total Synthesis of (±)-Phainanoid A
0116
Total Synthesis of (±)-Cephanolide B
0117
Synthesis of MK-0429
0118
Synthesis of (±)-Furanether A
0119
Synthesis of (–)-Bufospirostenin A
0120
Total Synthesis of Isorosthin L and Isoadenolin I
0121
Synthesis of an RP-Guanosine-3′,5′-Cyclic Phosphorothioate Analogue
0122
Total Synthesis of (+)-Schizozygine
0123
Synthesis of Corannulene

Synthesis of Heterocycles

z0125
All PDFs of this category
0125
Aziridination of Alkenes via Electrochemically Generated Thianthrenium Salts
0126
Synthesis of Isoindolinones from Isoxazoles by a Ring-Opening-and-Closing Cascade Reaction
0127
Synthesis of Complex Guanidines by [4+2]-Cycloaddition Indoles with N-Amidinyliminium Ions
0128
Palladium/Norbornene Cooperative Difunctionalization of Five-Membered Arenes
0129
One-Pot Diastereoselective Preparation of N-Alkenyl-2-Pyridones from 2-Halopyridinium Salts and Aldehydes
0130
Three-Dimensional Five-Membered Nitrogen- and Sulfur-Containing Heterocycles
0131
Direct C–H Functionalization of Azines by Electrochemical Manganese Catalysis
0132
Synthesis of Phenanthridinones by a Cascade Reaction under Mechanochemical Conditions
0133
Synthesis of Cyclobuta-Fused Tetrahydroquinolines
0134
Bridged Bicyclic Lactone Synthesis by Brønsted Acid-Promoted Formation of O-Acyloxocarbenium Ions
0135
Dihydroquinazolinones by a Base-Promoted Intermolecular Cyclization
0136
Acid-Catalyzed Ring Fragmentation to Access Functionalized Pyrroles
0137
C–H Activation To Form 2-Quinolin-8-ylisoquinolin-1(2H)-one Derivatives

Synthesis of Materials and Unnatural Products

z0139
All PDFs of this category
0139
Domino Cross-Scholl Reaction of Tetracene with Molecular Benzene
0140
Straightforward Access to Cyclopentadienyl Magnesium Bromides
0141
Easy Access to Dibenzo[a,e]cyclooctene-5,11(6H,12H)-diones
0142
Featuring Fullerenes and Ferrocenes
0143
Polyethylene Copolymers Without Ethylene
0144
Perfectly Balanced Antiaromaticity, As All Things Should Be
0145
Stitching Together a Silicon Ladder
0146
Synthesis of Thiazolo-Chlorin and Porphyrin Skeletons
0147
New Fluorescent BN-PAHs
0148
Making Conjugated COFs
0149
One-Step Installation of Boron
0150
Cascading into Polyurethanes

Metals in Synthesis

z0151
All PDFs of this category
0151
Like a Rolling Stone! Mechanochemical Synthesis of Grignard Reagents in Air
0152
Synthesis of C2-Symmetric Amines via Two Sequential Iridium-Catalyzed Reductive Aminations
0153
Iridium-Catalyzed Photosensitization of β-Dicarbonyls to Access Medium-Sized Rings
0154
One C Atom Out, Two C Atoms In: Homologation of α-Amino Acids to β-Amino Aldehydes
0155
Asymmetric C(sp3)–H/C(sp3)–H Umpolung Coupling of N-Allylimine and α-Aryl Ketones
0156
Nickel/Photoredox Domino Enantioselective Alkyl Arylation
0157
Iron-Catalyzed Intramolecular C–H Functionalization of Aliphatic Azides
0158
Classic Pd versus Radical Ni: Suzuki Cross-Coupling with Alkyl Fluorides under Pd and Ni Catalysis
0159
Nickel-Catalyzed Deoxygenative Arylation of α-Hydroxy Esters
0160
Accessing Enantioenriched Tetrahydroquinolines via Pd/Co Cooperative Catalysis
0161
Addition of Halopyridines Across C=C Double Bonds under Photoredox Catalysis
0162
Kinetic Resolution of 2° Phosphine Oxides Enabled by Palladium-Catalyzed Benzylation
0163
What the Heck? Bringing a New Dimension to a Well-Known Reaction with Diazo Compounds
0164
Cu Later Activator: Difluoromethylation of Alkyl Iodides Now Catalytic in Copper!
0165
Let the Nickel Do It Alone: Cross-Electrophile Coupling of Heteroaryl Chlorides and Aryl Chlorides
0166
Stereoselective Iron-Catalyzed Synthesis of (E)-Allylboronates from Allylic Alcohols
0167
Gold but not Old: Gold(I)-Catalyzed [2+2] and Formal (4+2) Cycloaddition of Ynol Ethers with Alkenes
0168
1,2-Carboamination of Alkenes with Arylboronic Acids and Amines Enabled by Directed Nickel Catalysis
0169
Pyridine-Pyridone Ligands with Different Bite Angles Enable Divergent Reactivity
0170
Atroposelective Synthesis of Axially Chiral Binaphthyl Derivatives by Nickel-Catalyzed C–O Bond Activation
0171
Modular Synthesis of Benzocyclobutanes and Indolines Using Sequential Copper and Palladium Catalysis
0172
Synthesis of Benzocyclobutenes via Pd(II)-Catalyzed C(sp3)–H Arylation
0173
Palladium-Catalyzed Carbonylative Coupling of Difluorohalides and Alkyl Boranes
0174
Enantioselective Synthesis of Spiro-γ-Lactams via Nitrenoid Transfer Protocol
0175
A Bimetallic Catalyst Enables the Synthesis of 1,5-Disubstituted 1,2,3-Triazoles
0176
Palladium as a π-Lewis Base Activator of Cyclopentadienones and their Umpolung Reactivity
0177
Cadmium–Chalcogenide Photocatalytic Selective Trifluoromethylation
0178
Highly Selective Hydroaminomethylation of Olefins Enabled by Cobalt Catalysis
0179
The Soai Reaction: The Origin of Asymmetry-Amplifying Autocatalysis

Polymer-Supported Synthesis

z0181
All PDFs of this category
0181
Reductive Electrophilic C–H Alkylation of Quinolines on a Supported Iridium Catalyst
0182
Oxidation of Arylboronic Acids and Aryl Aldehydes Catalyzed by Isotruxene-Based Porous Polymers
0183
Dehydrogenative Cross-Phenol Coupling on a Heterogeneous Oxovanadium Catalyst
0184
Aqueous Suzuki–Miyaura Cross-Coupling on a Self-Supported Nanoporous Palladium–Copper Alloy
0185
Heterogeneous Copper-Catalyzed Dehalogenative Deuteration of Aryl Bromides with D2O and CO
0186
Photoinduced Graphitic Carbon Nitride-Catalyzed C–H Thiocyanation
0187
Oxidation of Alcohols and Aerobic Oxidative Synthesis of Benzoxazoles on TEMPO-Functionalized FDU-15
0188
Suzuki–Miyaura Coupling on a Magnetic Silica-Supported Palladium Catalyst
0189
Redox-Neutral Mitsunobu Reaction on a Polystyrene-Supported Organophosphorus Catalyst
0190
Heterogeneous Iron-Catalyzed Oxidative Cleavage of 1,2-Diols to Carboxylic Acids or Ketones

Organo- and Biocatalysis

z0191
All PDFs of this category
0191
Photoenzymatic Catalysis Paves the Way for the Synthesis of Enantioenriched Tertiary Amines
0192
Organocatalytic Atroposelective N-Acylation for Synthesis of N–N Axially Chiral Compounds
0193
Visible-Light Photoredox-Catalytic Defluorinative Alkylation of α-Trifluorocarbonyl Compounds
0194
Chiral Phosphine-Catalyzed Asymmetric Tandem Isomerization/Annulation toward 3-Pyrrolines
0195
Identification and Characterization of the First Biological Rauhut–Currier Reaction
0196
Enantioselective Prins Cyclization of Alkenals through Brønsted Acid/Hydrogen-Bond Donor Co-catalysis
0197
Regiodivergent Furan Synthesis from 1,3-Dicarbonyl Compounds
0198
Asymmetric Construction of Quaternary Stereocenters by Addition of α-Alkynyl Ketones to Allenamides
0199
Organophotoredox-Catalytic α-Defluorinative Alkylation of Polyfluorinated Amides and Esters

Chemistry in Medicine and Biology

z0201
All PDFs of this category
0201
An Orally Available Clinical Candidate to Treat Covid-19
0202
Astercins: Sterol-Derived Cholesterol Transport Protein Inhibitors
0203
Identifying the Long Sought-After Ligand of the Sigma-2 Receptor
0204
C-Ar-Nucleosides by Nickel-Catalyzed Reaction
0205
Scratching the Surface of MRGPRX
0206
Photoaffinity Probe Elucidates Mechanism of Action of a COVID-19 Drug Candidate
0207
Uncaging Antisense Oligonucleotides with Small Molecules
0208
Synthesis of (–)-Glionitrin A and B
0209
Carbonyl Transposition Simplifies Synthesis
0210
Sweet Spot: Seneciobipyrrolidine Analogues on Glucose Homeostasis
0211
Benzoxaborole Inhibitor of CPSF3 for the Treatment of Visceral Leishmaniasis

Peptide Chemistry

z0213
All PDFs of this category
0213
Electrochemical Synthesis of Peptides Mediated by Triphenylphosphine
0214
Visible Light-Driven C–H Ketoalkylation of Glycine Derivatives with Cycloalkyl Peroxides
0215
Synthesis of Pyrazole-Based α-Amino Acids by Chiral Phosphoric Acid Catalysis
0216
Copper-Catalyzed Electrophilic Amination of Substituted Isoxazolidin-5-ones to Form β-Amino Acids
0217
Dynamic Kinetic Resolution to Access α-Amino Acid Esters
0218
Synthesis of Dehydroalanine Derivatives from Diamino Diacids by a Radical Process
0219
Synthesis of Na-Fmoc-Protected Amino Acid Esters and Peptides
0220
Copper-Catalyzed Synthesis of Thioamide Peptides

Flow Chemistry

z0221
All PDFs of this category
0221
Synthesis of Azetidinium Salts via Continuous-Flow
0222
Palladium-Catalyzed Reductive Amination in an Oscillatory Plug-Flow Reactor
0223
Leucinol-Catalyzed Asymmetric Aldol Reaction of Isatin and Acetone in Flow
0224
Electrochemical C–H Bond Activation under Flow Conditions
0225
Selective Heterogeneous Catalytic Hydrogenation of Nitriles in a Flow System