DOI: 10.1055/s-00000131

Synfacts

Issue 06 · Volume 18 · June 2022 DOI: 10.1055/s-012-53544

Synform

A81
Zanda, Matteo: SYNFORM ISSUE 2022/06

Synthesis of Natural Products and Potential Drugs

z0579
All PDFs of this category
0579
Synthesis of Belzutifan
0580
Synthesis of Antimalarial INE963
0581
Total Synthesis of (–)-Grayanotoxin III
0582
Synthesis of (–)-Gukulenin B
0583
Synthesis of (–)-3-Oxoisotaxodione
0584
Asymmetric Synthesis of the Cyclohexyl Fragment of BMS-986251
0585
Synthesis of the Tricyclic Core of BMS-986251
0586
Total Synthesis of (–)-Daphenylline
0587
Synthesis of (–)-γ-Lycorane
0588
Large-Scale Synthesis of AZD4573
0589
Synthesis of KRASG12C Inhibitors
0590
Asymmetric Synthesis of Giredestrant
0591
Synthesis of (±)-Myrioneurinol
0592
Second-Generation Synthesis of BMS-986224
0593
Synthesis of Orexin 2 Receptor Agonist TAK-925
0594
Synthesis of MK-1029
0595
Process for the Manufacture of Giredestrant (GDC-9545)
0596
Synthesis of a KRASG12C Inhibitor
0597
Total Synthesis of (±)-Ishwarane

Synthesis of Heterocycles

z0599
All PDFs of this category
0599
Cross-Coupling Approach to Partially Saturated Heterocycles
0600
Non-Radical-Mediated C–H Alkylation of Pyridines
0601
Regioselective Functionalization of Azoles
0602
C2-Selective SNH Amination of Pyrimidines through Selective Iminium Formation
0603
Robust Difluoromethylation of Nonactivated Ketones
0604
Synthesis of 5-Fluoroindolizines by Photocatalytic Defluorinative Coupling and SNV Cyclization
0605
2-Amino-3,3-difluoro-2,3-dihydrofurans from Difluorocarbenes and Enaminones
0606
Nickel-Mediated Allylation of Heterocycles
0607
Oxindole Synthesis through a Polar–Radical Crossover
0608
Naphthyridinone Formation through Palladium-Catalyzed Annulation of 1,6-Enynes and 2-Iodoanilines
0609
Synthesis of 2-Pyridones by Ring Expansion of Furans or γ-Lactams
0610
Gold and N-Heterocyclic Carbene Relay Catalyzed Synthesis of Pyrrole-Fused Lactones
0611
Selective Synthesis of Pyridines and Pyrimidines Using Isopropene Derivatives
0612
Synthesis of β-Aryl-γ-lactams and 2-Oxo-1,2-dihydroquinolines

Synthesis of Materials and Unnatural Products

z0613
All PDFs of this category
0613
Trouncing the Troublesome Trilactam
0614
Nonperipheral Functionalization of Triazatruxenes
0615
Nucleophilic Cyclodehydration of Enantiomerically Pure Helical Quinones
0616
Bundling Fluorine and Iodine on Unactivated Alkenes
0617
Ring, Ring! Directed Aromatic Homologation
0618
Copper-Catalyzed Unsymmetrical Trimerization of Indole towards Isotriazatruxene
0619
An Iterative Synthetic Route towards Unsaturated and Partially Saturated [7]Helicenes
0620
Cycloaddition with Stannoles to Make PAHs
0621
Helicenes Featuring Azulene
0622
Annulation à la Alumina
0623
Belt-Like Expanded Carbaporphyrins
0624
Solution-Mediated Synthesis of Cove-Edged Nanographene

Metals in Synthesis

z0625
All PDFs of this category
0625
Zirconium-Catalyzed Asymmetric β-Oxygen Elimination for the Desymmetrization of meso-Ketene Acetals
0626
Nickel-Catalyzed, Three-Component Silylalkylation and -Benzylation of Alkenes using Silylzinc Pivalates
0627
Biocatalytic Enantioselective 1-Carbon Ring Expansion via 1,2-Stevens Rearrangement
0628
Copper-Catalyzed Asymmetric Dynamic Kinetic C–P Coupling
0629
Cobalt-Catalyzed Aryl Cyanation of Symmetric Alkynes to Access E- and Z-Acrylonitriles
0630
Ni-Catalyzed Cyanation of Aryl Halides Using 1,4-Dicyanobenzene as an Easily Accessible Cyanide Source
0631
Pd-Catalyzed Deoxygenative Allylation and Olefination of Carbohydrates by an Umpolung Strategy
0632
NHCs as Remote Controls: Access to Isoindolines and β-Lactams via Pd-Catalyzed Remote C–H Functionalization
0633
Rhodium-Catalyzed Synthesis of Indanones via Ring Expansion of Benzocyclobutenones
0634
Dual NHC/Photocatalytic Dearomative Acyl Fluorination Reaction of Benzofurans
0635
Pd-Catalyzed Cross-Electrophile Coupling of Benzyl- and (Hetero)Arylbromides without External Reductant
0636
Selective Pd-Catalyzed β- and γ-C(sp3)–H Arylation of Aldehydes Enabled by Transient Directing Groups
0637
Cobalt- and Iridium-Catalyzed Mizoroki–Heck Reaction of Imidates Enabled by Energy and Electron Transfer
0638
Palladium-Catalyzed Synthesis of Chiral gem-Difluoromethylene-Containing 1,3-Dioxanes
0639
Rhodium-Catalyzed Transfer C−H Borylation of Alkenes with Vinyl Boronic Esters
0640
The A-Team: Iridium-Catalyzed Asymmetric Allylic Alkylation of Azaarenes (AAAA)
0641
Enantioselective Intramolecular Ir-Catalyzed Allylic Substitution Generating 8–11-Membered Lactones
0642
One-Carbon Homologation of Aryl Ketones via Formal 1,1-Insertion of Olefins via Rh-Catalyzed ‘Cut and Sew’
0643
Accessing Diamines from Free Amines via Nickel-Catalyzed Olefin Difunctionalization
0644
Deaminative Allylation of Katritzky Pyridinium Salts by Dual Cobalt/Organophotoredox Catalysis
0645
Triple Catalysis Enables the Preparation of Aromatic Aldehydes by a Desaturative Strategy
0646
Access to Chiral N-Alkylanilines by Enantioconvergent Alkylation with Racemic Tertiary Alkyl Electrophiles
0647
Desymmetrization of Malononitriles by Intramolecular Nickel-Catalyzed Reductive Cross-Coupling
0648
Ligand-Controlled Regiodivergent Asymmetric Cu-Catalyzed Carbonyl Addition of Vinyl Heteroarenes
0649
The Perfect Couple: Dehydrogenative Ring-Opening of Cycloalkanols by Cobalt/Organophotoredox Catalysis
0650
Catalyst-Controlled Regiodivergent Transformations of Internal Propargyl Esters
0651
The Narasaka–Heck Cyclization

Polymer-Supported Synthesis

z0653
All PDFs of this category
0653
Acceptorless Alcohol Dehydrogenation with an Iron–Cobalt Double-Atom Catalyst
0654
Photocatalytic Synthesis of Trisubstituted Pyridines with Vinylene-Linked Covalent Organic Frameworks
0655
Borrowing-Hydrogen Reaction Catalyzed by Iridium on a Porous Polypyridine-Oxadiazole
0656
Palladium-Catalyzed Benzylic Oxidation of Alkylarenes with Water as an Oxygen Source
0657
Meerwein–Ponndorf–Verley Reduction on Zirconium(IV) Coordinated to Amberlyst-15
0658
Photocatalytic Giese-Type Reaction on a Truxene-Based Hypercrosslinked Polymer
0659
Intermolecular [2+2] Photocycloadditions of Aromatic Alkenes Promoted by CdSe Quantum Dots
0660
PdAu/g-C3N4-Catalyzed Hydrodeoxygenation of Benzaldehydes with Formic Acid as a Hydrogen Donor
0661
Three-Component Regioselective Cycloaddition by a Copper Single-Atom Catalyst Supported on C3N4
0662
Hydrophosphinylation of Alkenes Catalyzed by Single-Atom Copper on Aluminum-Doped Magnesia
0663
Carboxylation of Sodium Arylsulfinates with CO2 on a Potassium–Copper–Titania Composite

Organo- and Biocatalysis

z0665
All PDFs of this category
0665
Modified Flavins Permit Catalytic Reductive Cyclization
0666
Organocatalytic Enantioselective Cascade Process for Constructing Azabicyclo[3.3.1]nonane Scaffolds
0667
Atroposelective Synthesis of N-Arylindoles by Brønsted Acid-Catalyzed Cyclization of Ynamides
0668
An Organocatalytic Approach for Remote C(sp3)−H Bond Hydroxylation
0669
Biocatalytic Synthesis of Azetidines by Enantioselective [1,2]-Stevens Rearrangement of Aziridines
0670
Biocatalytic Decarboxylative Bromination of Electron-Rich Cinnamic Acids
0671
Hypoiodite Permits Enantioselective Dearomatization of Indoles
0672
Biaryl Bond Formation Enabled by Biocatalytic Oxidative Cross-Coupling Reactions
0673
Photoredox Organocatalytic Enantioselective Synthesis of 1,7-Dicarbonyl Compounds via γ-Keto Radicals
0674
Dual Carbene and Photoredox Catalysis Permits Tandem Cyclization to Cyclic Benzylic Ketones
0675
Organocatalytic Hydrogen Atom Transfer System for C−H Functionalization
0676
Friedel–Crafts Polymerization Approach to Easily Recyclable Heterogeneous Chiral Phosphoric Acids

Chemistry in Medicine and Biology

z0677
All PDFs of this category
0677
Targeted Protein Stabilization with DUBTACs
0678
Take it Easy on the Synthesis of Cannabidiol Derivatives
0679
Spatiotemporal Labeling Through Photocatalytic Oxidation of Dihydrotetrazines
0680
Acyl Silanes: The Newest Photoaffinity Labeling Probe
0681
LZ-2112 – A Diterpene that Potentiates Antibiotics
0682
A Dual Inhibitor as a Potential Treatment for Alzheimer’s Disease
0683
Scalable Synthesis of a Payload for Antibody–Drug Conjugate Studies
0684
Sweet Mannose Antibiotic: Stereoselective Synthesis and Stereochemical Assignment of A-94964
0685
Potent Anti-Gastric Cancer Alkaloids from Traditional Medicine
0686
Live-Cell Imaging of Glycosidase Activity Using Bis-Acetal-Based Fluorogenic Probes
0687
Enlightening a Radical: A Convergent Total Synthesis of (+)-Actinobolin and Potent Analogues
0688
Synthesis of the Potent Antibiotic Amycolamicin
0689
First Asymmetric Synthesis of (+)-Thienamycin
0690
Evaluation of Benzopyrrolizidinone Pharmacophores Against NMDA-Induced Nerve Cell Injury

Peptide Chemistry

z0691
All PDFs of this category
0691
Dipeptide Synthesis by Two-Component Organocatalysis
0692
Site-Selective Alkylation for the Synthesis of Azapeptides
0693
Urethane-Protected Amino Acid N-Carboxyanhydride Synthesis in a Microflow System
0694
Nickel-Catalyzed Enantioselective Synthesis of Unnatural Amino Acids
0695
C–H Azidation of Peptides and Applications of the Products
0696
Arene Triazene Reaction for Macrocyclization of Unprotected Peptides
0697
Ruthenium-Catalyzed Synthesis of Unnatural Amino Acids through Transfer Hydrogenation of Enamides
0698
Iridium-Catalyzed N-Alkylation of α-Amino Esters and Amides
0699
Synthesis of Versatile N-Protected Amino Acid Esters from Aryl 4-Nitrosulfonates
0700
Construction of N,O-Acetals of Unnatural Amino Acids from Diethyl Mesoxalate Derivatives

Flow Chemistry

z0701
All PDFs of this category
0701
Synthesis of (R)-Tamsulosin Using Heterogeneous Catalysis in Flow
0702
Amide Bond Formation under Flow Conditions