Synfacts

Issue 06 · June 2022

Recommend Journal

Issue
Synform
A81
SYNFORM ISSUE 2022/06 FREE ACCESS

Full Text

PDF (2738 kb)
Synthesis of Natural Products and Potential Drugs
z0579
All PDFs of this category

Full Text

PDF (569 kb)
0579
Synthesis of Belzutifan FREE ACCESS

Full Text

HTML

PDF (139 kb)
0580
Synthesis of Antimalarial INE963

Full Text

HTML

PDF (84 kb)
0581
Total Synthesis of (–)-Grayanotoxin III FREE ACCESS

Full Text

HTML

PDF (132 kb)
0582
Synthesis of (–)-Gukulenin B

Full Text

HTML

PDF (87 kb)
0583
Synthesis of (–)-3-Oxoisotaxodione

Full Text

HTML

PDF (95 kb)
0584
Asymmetric Synthesis of the Cyclohexyl Fragment of BMS-986251

Full Text

HTML

PDF (96 kb)
0585
Synthesis of the Tricyclic Core of BMS-986251

Full Text

HTML

PDF (91 kb)
0586
Total Synthesis of (–)-Daphenylline

Full Text

HTML

PDF (84 kb)
0587
Synthesis of (–)-γ-Lycorane

Full Text

HTML

PDF (103 kb)
0588
Large-Scale Synthesis of AZD4573

Full Text

HTML

PDF (81 kb)
0589
Synthesis of KRAS^G12C Inhibitors

Full Text

HTML

PDF (95 kb)
0590
Asymmetric Synthesis of Giredestrant

Full Text

HTML

PDF (99 kb)
0591
Synthesis of (±)-Myrioneurinol

Full Text

HTML

PDF (84 kb)
0592
Second-Generation Synthesis of BMS-986224

Full Text

HTML

PDF (83 kb)
0593
Synthesis of Orexin 2 Receptor Agonist TAK-925

Full Text

HTML

PDF (73 kb)
0594
Synthesis of MK-1029

Full Text

HTML

PDF (82 kb)
0595
Process for the Manufacture of Giredestrant (GDC-9545)

Full Text

HTML

PDF (84 kb)
0596
Synthesis of a KRAS^G12C Inhibitor

Full Text

HTML

PDF (93 kb)
0597
Total Synthesis of (±)-Ishwarane FREE ACCESS

Full Text

HTML

PDF (127 kb)
Synthesis of Heterocycles
z0599
All PDFs of this category

Full Text

PDF (393 kb)
0599
Cross-Coupling Approach to Partially Saturated Heterocycles

Full Text

HTML

PDF (82 kb)
0600
Non-Radical-Mediated C–H Alkylation of Pyridines

Full Text

HTML

PDF (86 kb)
0601
Regioselective Functionalization of Azoles

Full Text

HTML

PDF (88 kb)
0602
C2-Selective S_NH Amination of Pyrimidines through Selective Iminium Formation

Full Text

HTML

PDF (87 kb)
0603
Robust Difluoromethylation of Nonactivated Ketones

Full Text

HTML

PDF (85 kb)
0604
Synthesis of 5-Fluoroindolizines by Photocatalytic Defluorinative Coupling and S_NV Cyclization

Full Text

HTML

PDF (109 kb)
0605
2-Amino-3,3-difluoro-2,3-dihydrofurans from Difluorocarbenes and Enaminones

Full Text

HTML

PDF (92 kb)
0606
Nickel-Mediated Allylation of Heterocycles

Full Text

HTML

PDF (79 kb)
0607
Oxindole Synthesis through a Polar–Radical Crossover

Full Text

HTML

PDF (88 kb)
0608
Naphthyridinone Formation through Palladium-Catalyzed Annulation of 1,6-Enynes and 2-Iodoanilines

Full Text

HTML

PDF (78 kb)
0609
Synthesis of 2-Pyridones by Ring Expansion of Furans or γ-Lactams

Full Text

HTML

PDF (104 kb)
0610
Gold and N-Heterocyclic Carbene Relay Catalyzed Synthesis of Pyrrole-Fused Lactones

Full Text

HTML

PDF (98 kb)
0611
Selective Synthesis of Pyridines and Pyrimidines Using Isopropene Derivatives FREE ACCESS

Full Text

HTML

PDF (145 kb)
0612
Synthesis of β-Aryl-γ-lactams and 2-Oxo-1,2-dihydroquinolines

Full Text

HTML

PDF (94 kb)
Synthesis of Materials and Unnatural Products
z0613
All PDFs of this category

Full Text

PDF (307 kb)
0613
Trouncing the Troublesome Trilactam

Full Text

HTML

PDF (84 kb)
0614
Nonperipheral Functionalization of Triazatruxenes

Full Text

HTML

PDF (89 kb)
0615
Nucleophilic Cyclodehydration of Enantiomerically Pure Helical Quinones

Full Text

HTML

PDF (93 kb)
0616
Bundling Fluorine and Iodine on Unactivated Alkenes

Full Text

HTML

PDF (71 kb)
0617
Ring, Ring! Directed Aromatic Homologation

Full Text

HTML

PDF (75 kb)
0618
Copper-Catalyzed Unsymmetrical Trimerization of Indole towards Isotriazatruxene

Full Text

HTML

PDF (80 kb)
0619
An Iterative Synthetic Route towards Unsaturated and Partially Saturated [7]Helicenes

Full Text

HTML

PDF (82 kb)
0620
Cycloaddition with Stannoles to Make PAHs

Full Text

HTML

PDF (87 kb)
0621
Helicenes Featuring Azulene

Full Text

HTML

PDF (92 kb)
0622
Annulation à la Alumina

Full Text

HTML

PDF (92 kb)
0623
Belt-Like Expanded Carbaporphyrins

Full Text

HTML

PDF (75 kb)
0624
Solution-Mediated Synthesis of Cove-Edged Nanographene

Full Text

HTML

PDF (88 kb)
Metals in Synthesis
z0625
All PDFs of this category

Full Text

PDF (740 kb)
0625
Zirconium-Catalyzed Asymmetric β-Oxygen Elimination for the Desymmetrization of meso-Ketene Acetals FREE ACCESS

Full Text

HTML

PDF (154 kb)
0626
Nickel-Catalyzed, Three-Component Silylalkylation and -Benzylation of Alkenes using Silylzinc Pivalates

Full Text

HTML

PDF (74 kb)
0627
Biocatalytic Enantioselective 1-Carbon Ring Expansion via 1,2-Stevens Rearrangement FREE ACCESS

Full Text

HTML

PDF (124 kb)
0628
Copper-Catalyzed Asymmetric Dynamic Kinetic C–P Coupling

Full Text

HTML

PDF (83 kb)
0629
Cobalt-Catalyzed Aryl Cyanation of Symmetric Alkynes to Access E- and Z-Acrylonitriles

Full Text

HTML

PDF (85 kb)
0630
Ni-Catalyzed Cyanation of Aryl Halides Using 1,4-Dicyanobenzene as an Easily Accessible Cyanide Source

Full Text

HTML

PDF (87 kb)
0631
Pd-Catalyzed Deoxygenative Allylation and Olefination of Carbohydrates by an Umpolung Strategy

Full Text

HTML

PDF (77 kb)
0632
NHCs as Remote Controls: Access to Isoindolines and β-Lactams via Pd-Catalyzed Remote C–H Functionalization

Full Text

HTML

PDF (98 kb)
0633
Rhodium-Catalyzed Synthesis of Indanones via Ring Expansion of Benzocyclobutenones

Full Text

HTML

PDF (87 kb)
0634
Dual NHC/Photocatalytic Dearomative Acyl Fluorination Reaction of Benzofurans

Full Text

HTML

PDF (93 kb)
0635
Pd-Catalyzed Cross-Electrophile Coupling of Benzyl- and (Hetero)Arylbromides without External Reductant

Full Text

HTML

PDF (74 kb)
0636
Selective Pd-Catalyzed β- and γ-C(sp³)–H Arylation of Aldehydes Enabled by Transient Directing Groups

Full Text

HTML

PDF (102 kb)
0637
Cobalt- and Iridium-Catalyzed Mizoroki–Heck Reaction of Imidates Enabled by Energy and Electron Transfer

Full Text

HTML

PDF (94 kb)
0638
Palladium-Catalyzed Synthesis of Chiral gem-Difluoromethylene-Containing 1,3-Dioxanes

Full Text

HTML

PDF (105 kb)
0639
Rhodium-Catalyzed Transfer C−H Borylation of Alkenes with Vinyl Boronic Esters

Full Text

HTML

PDF (92 kb)
0640
The A-Team: Iridium-Catalyzed Asymmetric Allylic Alkylation of Azaarenes (AAAA)

Full Text

HTML

PDF (82 kb)
0641
Enantioselective Intramolecular Ir-Catalyzed Allylic Substitution Generating 8–11-Membered Lactones

Full Text

HTML

PDF (95 kb)
0642
One-Carbon Homologation of Aryl Ketones via Formal 1,1-Insertion of Olefins via Rh-Catalyzed ‘Cut and Sew’

Full Text

HTML

PDF (83 kb)
0643
Accessing Diamines from Free Amines via Nickel-Catalyzed Olefin Difunctionalization

Full Text

HTML

PDF (77 kb)
0644
Deaminative Allylation of Katritzky Pyridinium Salts by Dual Cobalt/Organophotoredox Catalysis

Full Text

HTML

PDF (87 kb)
0645
Triple Catalysis Enables the Preparation of Aromatic Aldehydes by a Desaturative Strategy

Full Text

HTML

PDF (77 kb)
0646
Access to Chiral N-Alkylanilines by Enantioconvergent Alkylation with Racemic Tertiary Alkyl Electrophiles

Full Text

HTML

PDF (94 kb)
0647
Desymmetrization of Malononitriles by Intramolecular Nickel-Catalyzed Reductive Cross-Coupling

Full Text

HTML

PDF (86 kb)
0648
Ligand-Controlled Regiodivergent Asymmetric Cu-Catalyzed Carbonyl Addition of Vinyl Heteroarenes

Full Text

HTML

PDF (88 kb)
0649
The Perfect Couple: Dehydrogenative Ring-Opening of Cycloalkanols by Cobalt/Organophotoredox Catalysis

Full Text

HTML

PDF (87 kb)
0650
Catalyst-Controlled Regiodivergent Transformations of Internal Propargyl Esters

Full Text

HTML

PDF (86 kb)
0651
The Narasaka–Heck Cyclization FREE ACCESS

Full Text

HTML

PDF (136 kb)
Polymer-Supported Synthesis
z0653
All PDFs of this category

Full Text

PDF (416 kb)
0653
Acceptorless Alcohol Dehydrogenation with an Iron–Cobalt Double-Atom Catalyst FREE ACCESS

Full Text

HTML

PDF (125 kb)
0654
Photocatalytic Synthesis of Trisubstituted Pyridines with Vinylene-Linked Covalent Organic Frameworks

Full Text

HTML

PDF (191 kb)
0655
Borrowing-Hydrogen Reaction Catalyzed by Iridium on a Porous Polypyridine-Oxadiazole

Full Text

HTML

PDF (87 kb)
0656
Palladium-Catalyzed Benzylic Oxidation of Alkylarenes with Water as an Oxygen Source

Full Text

HTML

PDF (82 kb)
0657
Meerwein–Ponndorf–Verley Reduction on Zirconium(IV) Coordinated to Amberlyst-15

Full Text

HTML

PDF (76 kb)
0658
Photocatalytic Giese-Type Reaction on a Truxene-Based Hypercrosslinked Polymer

Full Text

HTML

PDF (106 kb)
0659
Intermolecular [2+2] Photocycloadditions of Aromatic Alkenes Promoted by CdSe Quantum Dots

Full Text

HTML

PDF (87 kb)
0660
PdAu/g-C₃N₄-Catalyzed Hydrodeoxygenation of Benzaldehydes with Formic Acid as a Hydrogen Donor

Full Text

HTML

PDF (75 kb)
0661
Three-Component Regioselective Cycloaddition by a Copper Single-Atom Catalyst Supported on C₃N₄

Full Text

HTML

PDF (76 kb)
0662
Hydrophosphinylation of Alkenes Catalyzed by Single-Atom Copper on Aluminum-Doped Magnesia

Full Text

HTML

PDF (71 kb)
0663
Carboxylation of Sodium Arylsulfinates with CO₂ on a Potassium–Copper–Titania Composite

Full Text

HTML

PDF (76 kb)
Organo- and Biocatalysis
z0665
All PDFs of this category

Full Text

PDF (440 kb)
0665
Modified Flavins Permit Catalytic Reductive Cyclization FREE ACCESS

Full Text

HTML

PDF (135 kb)
0666
Organocatalytic Enantioselective Cascade Process for Constructing Azabicyclo[3.3.1]nonane Scaffolds

Full Text

HTML

PDF (87 kb)
0667
Atroposelective Synthesis of N-Arylindoles by Brønsted Acid-Catalyzed Cyclization of Ynamides

Full Text

HTML

PDF (92 kb)
0668
An Organocatalytic Approach for Remote C(sp³)−H Bond Hydroxylation

Full Text

HTML

PDF (97 kb)
0669
Biocatalytic Synthesis of Azetidines by Enantioselective [1,2]-Stevens Rearrangement of Aziridines

Full Text

HTML

PDF (95 kb)
0670
Biocatalytic Decarboxylative Bromination of Electron-Rich Cinnamic Acids

Full Text

HTML

PDF (85 kb)
0671
Hypoiodite Permits Enantioselective Dearomatization of Indoles

Full Text

HTML

PDF (101 kb)
0672
Biaryl Bond Formation Enabled by Biocatalytic Oxidative Cross-Coupling Reactions

Full Text

HTML

PDF (101 kb)
0673
Photoredox Organocatalytic Enantioselective Synthesis of 1,7-Dicarbonyl Compounds via γ-Keto Radicals

Full Text

HTML

PDF (99 kb)
0674
Dual Carbene and Photoredox Catalysis Permits Tandem Cyclization to Cyclic Benzylic Ketones

Full Text

HTML

PDF (93 kb)
0675
Organocatalytic Hydrogen Atom Transfer System for C−H Functionalization

Full Text

HTML

PDF (86 kb)
0676
Friedel–Crafts Polymerization Approach to Easily Recyclable Heterogeneous Chiral Phosphoric Acids

Full Text

HTML

PDF (84 kb)
Chemistry in Medicine and Biology
z0677
All PDFs of this category

Full Text

PDF (602 kb)
0677
Targeted Protein Stabilization with DUBTACs FREE ACCESS

Full Text

HTML

PDF (149 kb)
0678
Take it Easy on the Synthesis of Cannabidiol Derivatives

Full Text

HTML

PDF (78 kb)
0679
Spatiotemporal Labeling Through Photocatalytic Oxidation of Dihydrotetrazines

Full Text

HTML

PDF (186 kb)
0680
Acyl Silanes: The Newest Photoaffinity Labeling Probe

Full Text

HTML

PDF (84 kb)
0681
LZ-2112 – A Diterpene that Potentiates Antibiotics

Full Text

HTML

PDF (110 kb)
0682
A Dual Inhibitor as a Potential Treatment for Alzheimer’s Disease

Full Text

HTML

PDF (86 kb)
0683
Scalable Synthesis of a Payload for Antibody–Drug Conjugate Studies

Full Text

HTML

PDF (92 kb)
0684
Sweet Mannose Antibiotic: Stereoselective Synthesis and Stereochemical Assignment of A-94964

Full Text

HTML

PDF (99 kb)
0685
Potent Anti-Gastric Cancer Alkaloids from Traditional Medicine

Full Text

HTML

PDF (85 kb)
0686
Live-Cell Imaging of Glycosidase Activity Using Bis-Acetal-Based Fluorogenic Probes

Full Text

HTML

PDF (95 kb)
0687
Enlightening a Radical: A Convergent Total Synthesis of (+)-Actinobolin and Potent Analogues

Full Text

HTML

PDF (99 kb)
0688
Synthesis of the Potent Antibiotic Amycolamicin

Full Text

HTML

PDF (90 kb)
0689
First Asymmetric Synthesis of (+)-Thienamycin FREE ACCESS

Full Text

HTML

PDF (136 kb)
0690
Evaluation of Benzopyrrolizidinone Pharmacophores Against NMDA-Induced Nerve Cell Injury

Full Text

HTML

PDF (88 kb)
Peptide Chemistry
z0691
All PDFs of this category

Full Text

PDF (363 kb)
0691
Dipeptide Synthesis by Two-Component Organocatalysis FREE ACCESS

Full Text

HTML

PDF (117 kb)
0692
Site-Selective Alkylation for the Synthesis of Azapeptides

Full Text

HTML

PDF (71 kb)
0693
Urethane-Protected Amino Acid N-Carboxyanhydride Synthesis in a Microflow System

Full Text

HTML

PDF (93 kb)
0694
Nickel-Catalyzed Enantioselective Synthesis of Unnatural Amino Acids

Full Text

HTML

PDF (71 kb)
0695
C–H Azidation of Peptides and Applications of the Products

Full Text

HTML

PDF (73 kb)
0696
Arene Triazene Reaction for Macrocyclization of Unprotected Peptides

Full Text

HTML

PDF (88 kb)
0697
Ruthenium-Catalyzed Synthesis of Unnatural Amino Acids through Transfer Hydrogenation of Enamides

Full Text

HTML

PDF (81 kb)
0698
Iridium-Catalyzed N-Alkylation of α-Amino Esters and Amides

Full Text

HTML

PDF (94 kb)
0699
Synthesis of Versatile N-Protected Amino Acid Esters from Aryl 4-Nitrosulfonates FREE ACCESS

Full Text

HTML

PDF (129 kb)
0700
Construction of N,O-Acetals of Unnatural Amino Acids from Diethyl Mesoxalate Derivatives

Full Text

HTML

PDF (90 kb)
Flow Chemistry
z0701
All PDFs of this category

Full Text

PDF (113 kb)
0701
Synthesis of (R)-Tamsulosin Using Heterogeneous Catalysis in Flow

Full Text

HTML

PDF (94 kb)
0702
Amide Bond Formation under Flow Conditions

Full Text

HTML

PDF (73 kb)
Most Read
Archive
Articles by Category
Free Sample Issue

Journal

More About This Journal
Synfacts Videos
Editorial Board
Editorial Office
Brochure

Authors

Instructions for Authors

Subscription

Subscription Information & Contacts
Institutional Licensing

Nobel Prize 2016

Instructions for Authors

Journals
Book Series
Login
Help
Portal
Return to Classic Website

German English

Thieme E-Books & E-Journals is a service of Georg Thieme Verlag and Thieme Medical Publishers, Inc.
© Georg Thieme Verlag KG

Imprint | Privacy policy statement

Your Current IP Address: 3.138.178.145