DOI: 10.1055/s-00000131

Synfacts

Ausgabe 07 · Volume 18 · Juli 2022 DOI: 10.1055/s-012-53974

Synform

A101
Zanda, Matteo: SYNFORM ISSUE 2022/07

Synthesis of Natural Products and Potential Drugs

z0703
All PDFs of this category
0703
Total Synthesis of (–)-Phaeocaulisin A
0704
Iridium-Catalyzed Asymmetric Hydrogenation of an Indenopyridine: 11β-HSD-1 Inhibitor
0705
Synthesis of a Respiratory Syncytial Virus Drug Candidate
0706
Total Synthesis of (+)-Elansolid A
0707
Synthesis of (+)-Cochlearol B
0708
Formal Synthesis of PF-06873600
0709
Total Synthesis of (±)-Ocellatusone C
0710
Synthesis of Roxadustat
0711
Synthesis of Verinurad
0712
Synthesis of Antimalarial BRD5018
0713
Synthesis of a Farnesoid X Receptor Agonist
0714
Large-Scale Synthesis of the 2′-C-Methyluridine Core of Uprifosbuvir
0715
Asymmetric Total Synthesis of (2R)-Hydroxynorneomajucin
0716
Synthesis of Upadacitinib
0717
Synthesis of QPX7728
0718
Synthesis of (+)-Decursivine
0719
Synthesis of (±)-Quadrone
0720
Synthesis of BACE1 Inhibitor E2609 (Elenbecestat)

Synthesis of Heterocycles

z0721
All PDFs of this category
0721
Preparation of 2-Aminopyridines and 2-Aminoazines by a Zincke Reaction
0722
Expeditious Robust Elaboration of Bicyclic N-Heterocycles
0723
Gram-Scale Synthesis of Fluorinated Pyrazoles and Pyridines
0724
Regioselective Functionalization of in situ Generated Heteroaryl Grignards with Tosyl Aziridines
0725
Gold/Iridium-Catalyzed Enantioselective Synthesis of Spiroketals and Spiroaminals
0726
Gold-Catalyzed Asymmetric Annulations of Enynone Derivatives and Nitrones Generated In Situ
0727
TEMPO Salt Mediated Oxidative Ugi–Azide Approach to Direct Functionalization of N-Heterocycles
0728
BINOL-Mediated Asymmetric Synthesis of Ammonium Salts
0729
Photocatalytic Conversion of Indoles into Spirocyclic Indolines
0730
Organophotoredox-Catalyzed Synthesis of Benzazepine Derivatives under Benign Conditions
0731
Tertiary Amines by Palladium-Mediated Allylic C–H Amination
0732
Copper-Catalyzed Borylation of (Het)aryl Carboxylic Acids
0733
Construction of Silicon Heterocycles by Cobalt-Catalyzed Hydrosilylation of Enynes

Synthesis of Materials and Unnatural Products

z0735
All PDFs of this category
0735
Picene Together a Geodesic Polyarene
0736
Heptagon-Embedded Monkey-Saddle-Shaped Nanographene via Photocyclization
0737
Thinking Inside the BOX for Helical, Isotactic Poly(NVC)s
0738
An Orthogonal Approach to Neutral Diradicals
0739
Treble Triptycenes, Triple the Thrill
0740
An Easy Prep for Triphenylenes
0741
Copper-Mediated Fullerooxazoles Synthesis
0742
Design of Bright Curved Dyes
0743
Flattened Triarylboranes
0744
Synthesis of Bibenzothiophene from Arylthiol and 1,3-Diynes
0745
Synthesis of C8-Aminated Pyrrolo-Phenanthridines or -Indoles via C–H Activation
0746
COF Remodeling

Metals in Synthesis

z0747
All PDFs of this category
0747
Take Two CO: Access to γ-Boryl Esters by Boration and Carbonylative Catenation of Styrenes in One Pot
0748
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of α-Keto Amides with Ammonium Salts
0749
Photoinduced Cobalt-Catalyzed Enantioselective Reductive Addition of Aryl Iodides to Aldehydes
0750
1,2-Alkylsulfenylation and -Selenolation of Alkenes with Organozinc Nucleophiles
0751
A Mild Nickel-Catalyzed Protocol for the α-Arylation of Amides Using Redox-Active Esters
0752
Kumada–Tamao–Corriu Cross-Coupling by Rhodium–Aluminum Cooperative Catalysis
0753
Nickel-Catalyzed C(sp3)–H Functionalization with Organohalides by Thermal Redox Coupling
0754
Enantioselective Arylborylation of Alkenes Catalyzed by Palladium
0755
Dearomative C2-Alkylation of Indoles Using Nickel Catalysis
0756
Asymmetric Synthesis of Dihydropyranes through a Catalytic Hetero-Diels–Alder Reaction
0757
New Electrophilic Sulfur Reagent and its Application in a Ni-Catalyzed syn-Carbosulfenylation of Alkenes
0758
Aminocarbonylation of Ethers under Cobalt Catalysis
0759
Stereoselective α-Alkylation of Esters with Oxyallenes Using Cooperative Catalysis
0760
A Palladium-Catalyzed Dearomative Carbonylation Approach to Polycyclic Indolines
0761
Co/Salox Catalyzed C–H Annulation of Arylphosphinamides with Alkynes and Allenes
0762
Synthesis of Aryl Nitriles by a Nickel-Catalyzed Aryl Exchange Reaction
0763
Hydrazone–Olefin and Oxime–Olefin Ring-Closing Metathesis
0764
Stuck Together! Acetylene as Molecular Glue for the Synthesis of Ethylene-Linked Functionalized Ketones
0765
One Out of Two! Selective Deoxygenative Reduction of 1,3-Diketones under Rhodium Catalysis
0766
Synthesis of Benzimidazolones and Benzimidazoles via Copper-Catalyzed C–H Amination/Annulation Cascade
0767
Amide-Directed Regioselective Hydroalkylation of Unactivated Alkenes under Nickel Hydride Catalysis
0768
Gold-Catalyzed Enantioselective Aminoarylation of Olefins
0769
Palladium-Catalyzed Desymmetrization of Olefins via Heck–Matsuda Coupling with Anilines
0770
Accessing 1,1-Diarylalkanes via a Ruthenium-Catalyzed meta-Selective C–H Functionalization
0771
Accessing Trimethylenemethane-Palladium Complexes with 2-Acetoxymethyl-3-allyltrimethylsilane
0772
The Chan–Evans–Lam Coupling

Polymer-Supported Synthesis

z0773
All PDFs of this category
0773
Ammoxidation of Alcohols with Aqueous Ammonia Using an Iron Single-Atom Catalyst
0774
Synthesis of Trisubstituted Imidazoles by Sulfonated Magnetic Cellulose-Nanoparticles
0775
Hydrothiolation of Alkenes and Alkynes on Carbon Nanotube-Supported Ru–Rh Nanoparticles
0776
Willgerodt–Kindler Reaction on Supported Silver Nanoparticles
0777
Asymmetric Aldol Reaction Catalyzed by a Chiral Proline-Substituted Porous Organic Cage
0778
Hydrolytic Oxidation of Hydrosilanes on PtCu Nanowires Encapsulated in Ir(III) Porphyrinic MOFs
0779
Hydrodeoxygenation of Lignin Derivatives Catalyzed by Kieselguhr-Supported Palladium Nanoparticles
0780
Suzuki–Miyaura and Ullmann Couplings of Aryl Chlorides Catalyzed by Silk-Fibroin-Supported Pd
0781
Reductive N-Alkylation of Amines with Aldehydes and Ketones on a Zirconia-Supported Pd Catalyst
0782
Hydrodeoxygenation of Acetophenone Derivatives on a an Iron–Ruthenium Bimetallic Catalyst
0783
Photocatalytic Cross-Coupling of Alkyl Silicates with Aryl or Alkenyl Bromides

Organo- and Biocatalysis

z0785
All PDFs of this category
0785
Multifunctional Biocatalyst for Iminium-Activated Conjugate Reduction/Reductive Amination
0786
Chiral Hexameric Resorcin[4]arene Capsules Enable Asymmetric Tail-to-Head Terpene Cyclizations
0787
Energy-Transfer-Induced Strain-Release [2π+2σ] Cycloadditions
0788
Stereoselective Dearomatizing Diels–Alder Reaction to Construct Complex Polycyclic Compounds
0789
Hydrazine-Catalyzed Ring-Opening Carbonyl–Olefin Metathesis between Cyclobutenes and Aldehydes
0790
Enantioselective Reactions of Primary Radicals Catalyzed by Engineered Ketoreductases
0791
Asymmetric Aldol Condensation Enables Diastereo­divergent Synthesis of Two-Axis Atropisomers
0792
NHC-Catalyzed Intramolecular SNAr Reaction of Styrenes for the Synthesis of Polyaromatic Compounds
0793
Cooperative Photoredox and Chiral Hydrogen-Bonding Catalysis Enables Enantioselective Radical Coupling
0794
1,3,2-Diazaphospholene Catalyst Enables Reductive Cyclizations of Organohalides
0795
Dual Lewis Base and Photoredox Catalysis Permits the Enantioselective Synthesis of Pyrrolidinones
0796
Visible-Light-Driven Organocatalytic Radical Addition to Imines

Chemistry in Medicine and Biology

z0797
All PDFs of this category
0797
A Natural Product Hybrid with Potent Antitumor Activity
0798
Breaking the Mirror: Deracemization of α-Branched Aldehydes
0799
Harnessing the Power of Organo- and Biocatalysis to Synthesize STING Agonist MK-1454
0800
Unexpected Hydrolytic Triazoloquinazoline Ring Opening Leads to a Potent HDAC6 Inhibitor
0801
Expanding the E3 Ligase Toolbox by Co-opting Methyl Readers
0802
Novel Macrocycle-Based Type-II TRK Inhibitors
0803
A Rapid Approach to Cyclopropane-Fused Lactams
0804
Tuning Colors of the Drug: A Systematic Study of the Emissive Features of the Deferasirox Scaffold
0805
A Reversible Covalent Inhibitor Targeting the BCR-ABL Active-Site Lysine
0806
Fluorogenic Cyclopropenones for Cellular Imaging
0807
An Improved Orthosteric Antagonist of the M5 Muscarinic Acetylcholine Receptor
0808
A Diastereoselective Cyclopropanation Strategy
0809
The First Total Synthesis of Bryostatin 7

Peptide Chemistry

z0811
All PDFs of this category
0811
1,2-Diaminotruxinic Bis-amino Acid Synthesis
0812
Site-Selective Replacement of N-Protecting Groups in Peptides
0813
A Novel Reagent for Coupling of Amino Acid Chlorides with Amino Acid Esters
0814
Lewis Acid/Palladium-Catalyzed Synthesis of α-Amino Acid Derivatives
0815
Synthesis of Carborane-Decorated Tryptophan-Containing Peptides
0816
Nickel/Copper-Catalyzed Synthesis of Tetrasubstituted Amino Acids
0817
Copper-Catalyzed Cross-Dehydrogenative Coupling for Amino Acid and Peptide Synthesis
0818
Synthesis of Functionalized and Macrocyclic Peptides by C–H Olefination
0819
α-Trifluoromethyl Amino Acid Synthesis by a Biocatalytic N–H Carbene Insertion

Flow Chemistry

z0821
All PDFs of this category
0821
Electrochemical Oxidation of Primary Alcohol in Single-Pass Continuous Flow
0822
Photochemical Synthesis of Alkyl Zinc Sulfinates under Flow Conditions
0823
Aerobic Oxidations of Aldehydes in Continuous Flow Catalyzed by N-Hydroxyphthalimide