DOI: 10.1055/s-00000131

Synfacts

Issue 09 · Volume 18 · September 2022 DOI: 10.1055/s-012-54752

Synform

A119
Zanda, Matteo: SYNFORM ISSUE 2022/09

Synthesis of Natural Products

z0941
All PDFs of this category
0941
Total Synthesis of (±)-Pleuromutilin
0942
Total Synthesis of (+)-Hypoestin A and (+)-Albolic Acid
0943
Synthesis of (–)-Cephanolide A
0944
Total Synthesis of (±)-Plecarpenone and (±)-Plecarpenene
0945
Total Synthesis of (±)-Deoxyaspidodispermine
0946
Synthesis of (–)-Spirochensilide A
0947
Total Synthesis of (+)-Asteriscanolide

Synthesis of Heterocycles

z0949
All PDFs of this category
0949
Three-Step Sequence to Pyrrolizidinones
0950
Access to Azaindolines through a Palladium-Catalyzed Heck Cyclization/Carbonylation Cascade
0951
(Arylethyl)amine Synthesis through Intramolecular Radical Cyclization of Sulfonamides and Alkenes
0952
One-Step Synthesis of Congested γ-Lactam-Based Polyheterocyclic Compounds
0953
Asymmetric Synthesis via Chlorine Radicals to Access Chiral α‑(Het)aryl Amines
0954
Base-Catalyzed Approach to Spirocyclic Oxazole Derivatives by a [3+2]-Cycloaddition Reaction
0955
Visible-Light-Promoted Metal-Free Couplings for Pyridine-Derived Small Molecules and DNA Derivatives
0956
Preparing Sulfonates by a Clauson–Kaas-Type Formation of Sulfonyl Pyrroles from Sulfonamides
0957
Rhodium-Catalyzed Approach to Seven- and Eight-Membered Lactams
0958
Rearrangement of 4-Alkenylisoxazol-5-ones to Pyrrole Analogues
0959
Hexafluoroisopropanol-Promoted Nitrogen-Insertion into S/Se,N-Heterocycles
0960
2,4,5-Trisubstituted 1,3-Oxazoles by [2+2+1]-Cycloaddition of Aldehydes and Nitriles
0961
Multicomponent Reaction to Synthesize Functionalized Spirocyclic 1,4-Diazaheterocycles

Synthesis of Materials and Unnatural Products

z0963
All PDFs of this category
0963
Altered Regioselectivity in a ‘Molecular Flask’
0964
Fluorescent Acenaphthylene-Fused Dibenzoullazines
0965
Severely Sterically Hindered Oligophenyls
0966
Conjugated Aromatic Dianion of Ambient Stability
0967
Facile Syntheses of 9-Arylfluorene and Spirobifluorene
0968
C–H/C–H Activation Enabled Heteroatom-Fused Phenyl-Pyridine
0969
Water-Soluble Poly(phenylacetylene)s from Living Polymerization in Water
0970
3D Porphyrinoids and BODIPY Cages
0971
TIPS-Acetylene Substituted Tetrabenzononacene
0972
Giant Polyphenylenes: Toward Tailored Nanographene
0973
Self-Correctible Conjugated 2D-COF
0974
7-Azahelicene Syntheses via Photocyclodehydrochlorination

Metals in Synthesis

z0975
All PDFs of this category
0975
Extrusion of Isocyanate from N-Allyl Amides Enables π-Allyl Palladium Chemistry!
0976
Gold-Catalyzed Oxidative Amidation of Halo-Alkynes with Anthranils
0977
Tungsten-Catalyzed Alkene Isomerization/Hydrocarbonylative Cyclization
0978
Transfer Vinylation and Dienylation from Allylic Alcohols to Ketones
0979
Pd(II)-Catalyzed Tandem β,γ-Dehydrogenation/Vinyl C–H Olefination/Lactonization of Aliphatic Acids
0980
Degree-Controllable Deacylative Alkyl Deuteration of Methyl Ketones under Copper Catalysis
0981
β-C–H Functionalization of Silyl Enol Ethers under Dual Nickel and Organophotoredox Catalysis
0982
Yne-Allylic Substitutions using Soft Nucleophiles under Copper Catalysis
0983
The Power of Two: Asymmetric Hydrocarbamoylation of Alkenes Enabled by Dual CuH/Pd Catalysis
0984
Asymmetric Synthesis of Strained cis-1,2-Silyl-Boryl-Cyclopropanes under Copper Catalysis
0985
Access to Acyl Fluorides by a Pd-Catalyzed Visible Light- and Ligand-Driven Carbonylation Reaction
0986
Cross-Coupling of Aryl Halides and Alkyl Boronic Esters under Dual Photoredox/Nickel Catalysis
0987
Nickel-Catalyzed Substitution of Phosphine Ligand Dearylation of Phosphonium Salts
0988
Efficient Palladium-Catalyzed Asymmetric Direct Alkynylation of Imines
0989
Deoxygenative Conjugate Addition of Alcohols to Michael Acceptors
0990
Enantioselective Hydrogenation of Oximes Enabled by Nickel Catalysis
0991
Palladium-Catalyzed Enantioselective Domino Heck C–H Activation Reactions
0992
Synthesis of Polycyclic Heterocycles via Palladium-Catalyzed Double C–H Activation of Aromatic Acids
0993
Asymmetric Synthesis of Arylthiomethyl-Substituted Cyclic Ethers by Copper-Catalyzed Oxysulfenylation
0994
Addition of Perfluoroalkyl Radicals to Isoxazolines Generating Amino-Ketone Products
0995
Synthesis of Amides by Copper-Catalyzed Aminocarbonylation of Alkyl Iodides
0996
Phosphonodifluoromethylation of Arylboronic Acids using a Nickel/Copper Dual Catalytic System
0997
Silver-Catalyzed Intermolecular Cross- and Homo-Coupling Reactions of Silyl Enol Ethers
0998
Sonogashira Coupling with Heterocyclic Phosphonium Salts
0999
Synthesis of Biaryl Monophosphines via Rhodium-Catalyzed Coupling of Phosphines and Aryl Bromides
1000
Pd(II)-Catalyzed Tandem Intramolecular β-C(sp3)–H Olefination/Lactonization Sequence
1001
Cobalt-Catalyzed Hydrohydroxylation of Olefins Using Molecular Oxygen – The Mukaiyama Hydration
1002
Palladium-Catalyzed Allylic Alkylation of Azlactones

Polymer-Supported Synthesis

z1003
All PDFs of this category
1003
Photocatalytic Synthesis of Primary Aryl Amines from Aryl Halides and Sodium Azide by Ni on Carbon Nitride
1004
Site-Isolated Cobalt Complex on Porous Carbon as a Catalyst for Hydrogenation of Nitro Compounds
1005
Guerbet Reaction of Primary Alcohols Catalyzed by DMF-Stabilized Ruthenium Nanoparticles
1006
Borrowing Hydrogen C3-Alkylation of Indoles on Doped-Carbon-Supported Cobalt Nanoparticles
1007
COF Layer Improves the Activity of a Pt Catalyst for the Hydrogenation of Carbonyl Compounds
1008
Oxidative Dehydrogenation of N-Heterocycles Promoted by N/P-Doped Carbon Materials
1009
Asymmetric Aza-Darzens Reaction on an Indium(III)-Based Supramolecular Host
1010
Asymmetric A3-Coupling Reaction Promoted by Chiral Covalent Organic Frameworks
1011
Hydrodeoxygenation of Primary Amides Promoted by a Ru–W Bimetallic Catalyst
1012
Nickel(II)-Photocatalyzed Hydroxylation of Aryl Chlorides with Water

Organo- and Biocatalysis

z1013
All PDFs of this category
1013
Hydrogen-Bond Catalyst Grants Access to Diverse Scope of Enantioenriched Stereogenic-at-P(V) Building Blocks
1014
DMAP-Catalyzed Intramolecular Enolate Addition to Dithioesters, Trithiocarbonates, and Xanthates
1015
HFIP-Mediated Hydroarylation of Moderately Electrophilic Enamides with Nonactivated Arenes
1016
Photo-Controlled Living Cationic Polymerization of 4-Methoxystyrene
1017
γ-Nitro β-Keto Amides Synthesis by Organocatalytic Michael Addition/Stereoconvergent Crystallization
1018
Asymmetric NHC-Catalyzed Brook–Benzoin Reaction of Acylsilanes with Indole-7-carboxaldehydes
1019
Visible-Light-Mediated Chiral-Phosphoric-Acid-Catalyzed Enantioselective Carbene Insertion
1020
Triplet-Sensitized Deracemization of Alkenes
1021
Biosynthesis of Sordarin by an Intramolecular Diels–Alder Reaction Catalyzed by a Novel Diels–Alderase
1022
Bisthioureas Permit Stereo- and Site-Selective Glycosylation of Minimally Protected Sugars
1023
Chemodivergent Benzylation of 4-Cyanopyridines by Using an Organophotocatalyst

Innovative Drug Discovery and Development

z1025
All PDFs of this category
1025
Synthesis of Danuglipron: An Orally Available GLP-1R Agonist
1026
Unveiling PROTAC Linker Effects by Direct-to-Biology Parallel Synthesis
1027
A Tunicamycin Analogue Inhibits Human Phosphotransferase, DPAGT1
1028
Iezoside – A New and Potent SERCA inhibitor
1029
A Pair of Bioorthogonal ‘Click and Release’ Reaction
1030
Photocatalyzed Tagging of Cell–Cell Interactions
1031
A New Tool for RNA Atomic Mutagenesis
1032
Design and Synthesis of NTQ1062, a new Akt Inhibitor Clinical Candidate
1033
Computer-Assisted Circular Economy in Drug Development
1034
A General Synthesis of Bioactive Terpenoids Produced by the Medicinal Fungus Using a Tandem Process
1035
Tracking with PACT: Cell Labeling Using Cyanine Probe Phototruncation
1036
New Clinical Leads for Pathological Thrombosis
1037
Selective Modification of N-Terminal Cysteine Residues
1038
mRNA Translation Enlightened
1039
Synthesis of an Aza-Cryptophycin Analogue
1040
A SAFE Approach for Multiplexed Immunofluorescence Imaging
1041
Isonitrile Couplings Enable a Modular Synthesis of Cyclosporin A

Peptide Chemistry

z1043
All PDFs of this category
1043
Synthesis of Peptides with the Formation of Highly Sterically Hindered Peptide Bonds
1044
Aza-Quasi-Favorskii Reaction Mediated by Potassium Hexamethyldisilazide
1045
Visible Light-Induced Cross-Coupling of Glycine Derivatives with β-Keto Esters
1046
Palladium-Catalyzed Aminoallylation for the Synthesis of α,α-Disubstituted Amino Acids
1047
Ruthenium-Catalyzed Hydroxylation of Tyrosine Residues in Peptides
1048
Asymmetric Synthesis of Quaternary Amino Acid Esters
1049
Rhodium-Catalyzed Ligation of Peptides with Olefins
1050
Synthesis of α-Benzyl Amino Acid Derivatives by Using a Ternary Catalyst
1051
1H-Fluoren-9-ylmethyl Chloroformate as a Coupling Reagent for Peptide Synthesis

Flow Chemistry

z1053
All PDFs of this category
1053
Palladium-Catalyzed Hydrogenation of Nitroolefins and Three-Step Homologation of Aldehydes
1054
Photochemical Formal [3+2] Cycloaddition for the Synthesis of Aminocyclopentanes in Flow
1055
Horner–Wadsworth–Emmons Olefination in Flow System by Photocatalysis