DOI: 10.1055/s-00000131

Synfacts

Issue 10 · Volume 18 · October 2022 DOI: 10.1055/s-012-55178

Synform

A151
Zanda, Matteo: SYNFORM ISSUE 2022/10

Synthesis of Natural Products

z1057
All PDFs of this category
1057
Synthesis of (–)-Tetrodotoxin
1058
Synthesis of (–)-Simplicissin
1059
Total Synthesis of Indolizidine Alkaloid (±)-Bipolamine I
1060
Total Synthesis of (+)-Alstonlarsine A
1061
Synthesis of (+)-Darobactin A
1062
Total Synthesis of (–)-Antroalbocin A
1063
Total Synthesis of (–)-Salsolene Oxide

Synthesis of Heterocycles

z1065
All PDFs of this category
1065
Copper-Catalyzed Isoxazole Synthesis
1066
TEMPO-Mediated Convergent Synthesis of Benzoxazoles from Primary Amines and Cyclohexanones
1067
Photoredox Cross-Coupling for Propellane-Curious Chemists
1068
One-Pot Cascade Synthesis of 2‑Azafluorenones Mediated by Generation of Ammonia in situ
1069
A Mild and Site-Selective Protocol for N1-Carboxylation of 2-Alkynylindoles
1070
NHC-Alcohol Adduct-Mediated Photocatalytic Deoxygenation for the Synthesis of 6-Phenanthridine Derivatives
1071
Carbonyl Compounds through Photochemical Olefin Cleavage
1072
α-C–H Functionalization of Alcohols Delivers C6-Hydroxyalkylated Purines and Purine Nucleosides
1073
Copper-Catalyzed Synthesis of Trifluoromethylated 4H-Pyrans
1074
Manganese(III) Acetate-Promoted Mild Sulfonation of (Het)arenes
1075
Facile Rearrangement of Oxetane-Carboxylic Acids to Lactones
1076
Multicomponent Approach to Functionalized Isoquinolines
1077
Synthesis of Pyrazoloimidazoquinazolinones and COVID-19 Protease Docking Studies
1078
Synthesis of 7-[(Arylsulfanyl)methyl]dibenzo[b,d]azepines

Synthesis of Materials and Unnatural Products

z1079
All PDFs of this category
1079
A Möbius Carbon Nanobelt Accomplished
1080
γ-Graphyne via Alkyne Metathesis
1081
Dibenzocarbazole from Decarboxylative Biscyclization
1082
Syntheses of PAHs Embedded with Azulene Modules
1083
Contorted PAHs via Cycloaddition to Cyclobutadienoids
1084
Cascade Polymer Degradation on the Trigger
1085
Quintuple [7]Helicene in One
1086
Ring-Fusion and Polymerization of Aza-Heteroaromatics
1087
B,N-Doped Emitters from Amine-Directed Borylation
1088
[3]Rotaxanes Threaded by Polyyne via Dicobalt Complexes
1089
Living Suzuki–Miyaura Catalyst-Transfer Polymerization

Metals in Synthesis

z1091
All PDFs of this category
1091
Site-Selective Allylic C–H Amination of Alkenes Enabled by Formation of an Aminium Radical Cation
1092
Dioxazolones as Masked Amides in the Copper-Promoted Reaction with Arylboronic Acids
1093
Stereospecific Functionalization of Activated Alkylboronic Esters under Copper Catalysis
1094
The Bigger the Better: ortho-Selective C–H Activation in Alkylarenes by Transient Benzylic C–H Activation
1095
Rh(III)-Catalyzed Diastereoselective Amino Oxygenation/Amination of 1,3-Dienes
1096
A Cyclopropane-Based Diphosphine Ligand Enables Regioselective Hydroboration of Internal Alkynes
1097
Regiodivergent Access to 1,1- or 1,2-Disubstituted Alkenes via Cobalt-Catalyzed Hydroalkylation of Alkynes
1098
Nickel-Catalyzed Cross-Electrophile Coupling of Heteroaryl Imines and Alkyl Halides
1099
Switching Regioselectivity in the Mizoroki–Heck-Reaction by Cooperative Triple Catalysis
1100
Nickel-Catalyzed Hydroalkylation of Trifluoromethylalkenes
1101
Enantioconvergent Nickel-Catalyzed α-Alkylation of Racemic Reformatsky Reagents
1102
Alkylation of Amines and Ammonia with Nitriles by Nickel-Catalyzed Hydrogenative Cross-Coupling
1103
Three-Component Coupling of Aldimine Esters, 1,3-Butadiene and Alkyl Bromides under Dual Catalysis
1104
Nickel-Catalyzed Enantioconvergent Cross-Electrophile Arylation and Vinylation of 1-Chloro-1-Alkanol Esters
1105
Deoxygenative Cross-Coupling of Benzyl Alcohols and Boronic Acids Enabled by Transient Isourea Formation
1106
Cu/Photoredox Dual-Catalytic Decarboxylative Sulfonylfluorination Reaction
1107
Nickel Electrocatalytic Sulfinylation of Aryl Halides using SO2
1108
Deoxygenative Cross-Coupling Reactions of Phenols Enabled by Transient O-Phenyl-Uronium Formation
1109
A Base-Free Protocol for the Rhodium-Catalyzed Benzylic Addition of Alkylarenes to Michael Acceptors
1110
Nickel-Catalyzed Isomerization/Cross-Coupling Reaction of Epoxides and Aryl Triflates
1111
C4 Alkylation of Pyridines Enabled by the Use of a Bulky Aluminum Lewis Acid and Nickel Catalysis
1112
Asymmetric Benzylic C(sp3)–H Trifluoromethylation by Dual Organophotoredox and Copper Catalysis
1113
Iron-Catalyzed Domino Cyclization of Methylene Cyclopropyl 1,6-Enynes
1114
Stereoselective Rh(III)-Catalyzed Cyclopropanation of Sulfoxonium Ylides with β,γ-Unsaturated Keto Esters
1115
Photo/Cobalt Dual Catalytic Enantioselective Hydroarylation of 1,6-Enynes
1116
Enantioselective Conjugate Addition of Alkenyl Heteroarenes with Alkene Nucleophiles
1117
The Enantioselective Tsuji Decarboxylative Allylic Alkylation
1118
Arylalkenylation of Alkynes Catalyzed by Nickel

Polymer-Supported Synthesis

z1119
All PDFs of this category
1119
Heck Reaction and Suzuki–Miyaura Cross-Coupling on a Humin-Like-Polymer-Immobilized Pd Catalyst
1120
Palladium Nanoparticles Catalyze the Oxidative Methoxylation of 8-Methylquinolines with Methanol
1121
Hydroamination of Arylacetylenes by Gold Nanoclusters Immobilized on Carbon
1122
C–P Cross-Coupling of Terminal Alkynes with H-Phosphonates by a Copper Photocatalyst
1123
Metal–Organic Layers Containing Ru Photosensitizers and Au Catalysts for Reactions of Aryldiazonium Salts
1124
Click Reactions Promoted by a Nanomagnetic Manganese(II)–Schiff Base Complex
1125
Photocatalytic C–N Coupling of Aryl Chlorides on a Copper Nanocluster
1126
Markovnikov Hydroaminocarbonylation of Alkenes and Alkynes with a Soluble Heterogeneous Pd Catalyst
1127
Visible-Light-Driven C–N Coupling Promoted by Nickel Single Atoms on Carbon Nitride
1128
Synthesis of Thiazolidin-4-ones and Hexahydroquinolines on Fe3O4@Urea-Benzoic Acid
1129
Dehydrogenative Condensation of N,N′-Disubstituted Ureas and 1,2-Diols on Pd/Al2O3

Organo- and Biocatalysis

z1131
All PDFs of this category
1131
Brønsted Acid Catalysis Permits Electrophilic Halogenation of Electron-Deficient Arenes
1132
Photocatalytic Decarboxylative Phosphorylation of α-Amino Esters of N-Hydroxyphthalimide
1133
Acridine Radicals Permit Reductive Coupling of Aliphatic and Aromatic Carbonyls with Olefins
1134
Organophotocatalytic Radical Difluoromethylation of Nonactivated Alkenes
1135
Photoenzymatic Intramolecular Cyclization of α-Chloroamides with Allylsilanes
1136
Organocatalytic Asymmetric Synthesis of Axially Chiral Cyclohexadienylidene Compounds
1137
Engineered Cytochrome P450 Permits Scalable Oxidative Biaryl Coupling toward Arylomycins
1138
Desymmetrization of meso-Cyclohexenediones through Dienamine Catalysis
1139
Base-Promoted Reductive Coupling of (Trifluoromethyl)arenes

Innovative Drug Discovery and Development

z1141
All PDFs of this category
1141
A β-Lactone for Covalent Inhibition of KRAS G12S
1142
A Novel Covalent Target for Inhibiting Pancreatic Cancer Stem Cell Growth
1143
Anticancer Dual Molecule Targeting Inhibition of Tubulin Polymerization and HDAC
1144
Improved Solubility of Contezolid via an O-Acyl Phosphoramidate Prodrug
1145
A Late-Stage Electrophilic Halogenation of Arenes with Electron-Withdrawing Substituents
1146
Deep-Near-IR Bioimaging Using Silicon-Substituted Bis-Benzannulated Rhodamine Dyes
1147
Synthesis of BLU-945, an EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer
1148
Improved Synthesis toward β-Lactam Antibiotics
1149
General Synthesis of TF-DUBTACs
1150
Thallusin – A Potent Chemical Mediator for Chemosynthetic Symbioses of Marine Organisms
1151
Overcoming Drug Resistance with Mechanistic Understanding
1152
Five-Step Synthesis of MDM2-p43 Inhibitor BI-0282
1153
A Convergent Synthesis of (+)-Ikarugamycin
1154
Enzyme Evolution as Key to Selective Bioconjugation

Peptide Chemistry

z1155
All PDFs of this category
1155
Preparation of Dehydroamino Acids/Peptides and their Application
1156
Palladium-Catalyzed Cyanomethylation of Amino Acids
1157
Photoredox C(sp3)–H Bond Activation to Form Tetrasubstituted Amino Acids
1158
Copper/Iridium-Catalyzed Cascade Reaction for the Synthesis of α-Deuterated α-Amino Acids
1159
Asymmetric Mannich Reaction for the Synthesis of β-Amino Amides
1160
Microwave-Assisted Aminocarbonylation of α-Amino Acid Esters
1161
α,β-Diamino Acid Synthesis by a Mannich-Type Reaction of Azlactones and 2-Aminoacrylates
1162
Iridium-Catalyzed Carbonyl Alkylative Amination Reaction under Blue LED Irradiation
1163
(Diethylamino)sulfur Trifluoride (DAST) for Fmoc-Amino Acyl Fluoride Synthesis

Flow Chemistry

z1165
All PDFs of this category
1165
Synthesis of Ketones via a Multiphoton Tandem Photoredox Protocol in Continuous Flow
1166
Flow Synthesis of 1,4-Benzothiazines from (E)-β-Chlorovinyl Ketones and 2,2′-Sulfanyldianilines