DOI: 10.1055/s-00000131

Synfacts

Issue 06 · Volume 19 · June 2023 DOI: 10.1055/s-013-57467

Synform

A98
Zanda, Matteo: SYNFORM ISSUE 2023/06

Synthesis of Natural Products

z0533
All PDFs of this category
0533
Total Synthesis of (–)-Naphthospironone A
0534
Synthesis of Mavacuran Alkaloids
0535
Synthesis of (–)-Illisimonin A
0536
Synthesis of (+)-Wickerol A and (+)-Wickerol B
0537
Total Synthesis of (+)-Strempeliopidine
0538
Synthesis of (+)-Coriamyrtin
0539
Total Synthesis of (±)-Talatisamine

Synthesis of Heterocycles

z0541
All PDFs of this category
0541
Sustainable Synthesis of Sym-Triazines
0542
Metal-Free Ring-Opening of Vinylcyclopropanes
0543
Chirality at Oxygen!!
0544
Robust Synthesis of (Hetero)Aryl and Aliphatic Sulfonyl Fluorides
0545
Silver-Catalyzed Synthesis of Phosphorus-Containing Fused-Azepines
0546
First Example of [5,6,5]-Tricyclic Bistetrazole Fused Explosive
0547
Diversity-Oriented Approach to Spirocyclic and Fused Pyrazolopyrrolidines
0548
Synthesis of Aryl Picolyl Sulfones via Formal C–H Activation
0549
Cobalt-Catalyzed Synthesis of Oxetanes and Azetidines
0550
Synthesis of N-Fluoroalkylated Morpholinos – An Application to the New Class of Nucleoside Analogues
0551
Photocatalyzed Synthesis of Multi-Substituted Pyridines from γ-Ketonitriles
0552
Switchable Multipath Cascade Cyclization via Chemodivergent Reaction

Synthesis of Materials and Unnatural Products

z0553
All PDFs of this category
0553
Neutral 6π and 10π Homoaromatics
0554
Aryl C–H Functionalization Guided by Boron
0555
Phosphine-Catalyzed 1,2-Diacylation of Alkynes
0556
Go Spiro or Helical?
0557
Azulenoazulenes
0558
‘Cation-Capped’ Oligoanthrylenes
0559
Modular Synthesis of Hexaaryl-s-Indacene
0560
Trilayered Double Helicenes
0561
Tetraquinoline Macrocycle
0562
1-Azahomocubane
0563
Catalyst-Free Synthesis of Benzo[b]fluorenes
0564
Stitching Large Aromatic Polyheterocycles

Metals in Synthesis

z0565
All PDFs of this category
0565
Ir-Catalyzed Regio- and Enantioselective Synthesis of β-Heteroaryl Amides via Site-Selective C–H Activation
0566
Synthesis of α-Alkylated Ketones via Nickel-Catalyzed Dehydrogenative Coupling of Alcohols
0567
An Electroreductive Approach to Nickel-Catalyzed Enantioselective Cross-Coupling of Aryl Aziridines
0568
Intramolecular Hiyama Coupling of Silyl-Tethered Aryl Triflates
0569
Copper-Catalyzed Synthesis of Alkyl-1,8- Diaminonaphthalene-Protected Boronic Acid
0570
Copper-Catalyzed Desymmetrization of Prochiral and Meso Alcohols with In Situ Generated Acyl Radicals
0571
Synthesis of β-Lactams by Palladium-Catalyzed Carbonylative Cyclization of Methylarenes and Imines
0572
Palladium-Catalyzed Enantioselective Synthesis of Spiro Ten-Membered Lactones
0573
Synthesis of [11C]Cyanated Arenes via a Copper-Mediated Sandmeyer-Type Radiocyanation
0574
Copper-Photocatalyzed Asymmetric Benzylic C(sp3)–H Functionalization with Amides and Carbamates
0575
Asymmetric Hydrosilylation of β,γ-Unsaturated Amides under Rhodium Catalysis
0576
Cobalt-Catalyzed Desymmetrizing Olefin Isomerization to Access All-Carbon Quaternary Stereocenters
0577
Gold-Catalyzed Syntheses of Fused- and Bridged-Ring Systems via a Cyclic Dienyl Gold Carbene Intermediates
0578
Nickel-Catalyzed Atroposelective Alkylation of Dinaphthofurans via C(sp2)–O Bond Cleavage
0579
Synthesis of Azepinodiindoles via a Copper-Catalyzed Tandem Cyclization/C(sp2)–H Annulation
0580
Copper-Catalyzed Synthesis of Propanedioic Acid Derivatives via a Carbene Carbonylation
0581
Iridium-Catalyzed Regioselective Hydroamination of Internal Alkenes under Chain-Walking
0582
Atroposelective Synthesis of Axially Chiral Styrenes by Nickel Hydride-Catalyzed Hydroarylation of Alkynes
0583
Nickel/Photoredox-Catalyzed Enantioconvergent Reductive Cross-Coupling of α-Bromo Phosphonates
0584
Palladium-Catalyzed Synthesis of 5,10-Dihydroindeno[1,2-b]indoles under Microwave Irradiation
0585
Synthesis of Chiral α-Aryl Carbonyl Compounds via a Stereoinvertive Suzuki–Miyaura Cross–Coupling
0586
Synthesis of α-Amino Phosphonates and Phosphines via Hydrosilylation and Iron-Catalyzed Phosphonylation
0587
A Palladium-Catalyzed Carbonylation Approach to 2-Cyano-N-acetamides and 2-Cyanoacetates
0588
Dual Photoredox/Nickel-Catalyzed Regioselective Olefin Carboacylation under Visible Light
0589
Stereoselective Arylation of Glycosyl Sulfones: Access to α- and β-Isomers
0590
Rhodium-Catalyzed [4+3] Cycloaddition of Diene-VCPs

Polymer-Supported Synthesis

z0591
All PDFs of this category
0591
Oxidative [3+2] Cycloaddition of Phenols with Styrenes Using a Photocatalytic COF
0592
Synthesis of 3-Butynoates from Terminal Alkynes Catalyzed by Copper Iodide Nanoparticles
0593
Oxidative Carbonylation of Indoles by a Rh-Exchanged Zeolite Catalyst
0594
Photo-Induced Carbon-Heteroatom Cross-Coupling with a Poly(heptazine imide)-Supported Ni Catalyst
0595
Cyclization of Propargyl Amines with CO2 Catalyzed by MOF-Supported Cu2O and DABCO
0596
Aerobic Oxidative Homo-Coupling of Benzylamines Using a Pt(II)-Coordinated Polymeric Photocatalyst
0597
Silylation of Alkyl Esters and Ethers Catalyzed by Gold Nanoparticles on Zirconium Oxides
0598
in situ Generated Fe Nanoparticles Containing ppm Levels of Ligated Pd for Cross-Coupling Reactions
0599
Hydroxylation of Arylboronic Acids by COFs Prepared by a Photocatalytic Multicomponent Reaction
0600
Deoxygenative Hydrogenation of Aromatic Aldehydes and Ketones by Pd Nanoparticles on Carbon Nitride
0601
Hydroboration of Alkenes and Alkynes Catalyzed by Rh–Ru Nanoparticles on Carbon Nanotubes

Organo- and Biocatalysis

z0603
All PDFs of this category
0603
Imidodiphosphorimidate(IDPi) Enables Enantioselective C(sp3)–H Insertion via Vinyl Cations
0604
Organophotocatalytic CO2 Reduction to Formate through Ascorbic Acid-Mediated Recycling of HAT Donor
0605
Unprecedented Terpenoid Skeletons Accessed via Supramolecular Capsule Catalysis
0606
Enzymatic Oxidation as a New Way to Synthesize Pharmaceutically Relevant Heteroaromatic Compounds
0607
Visible Light-Mediated Organocatalytic Reactions Between 1,3-Diketones and α-Aryl-α-Diazoesters
0608
Photocatalytic Transformation of Hydrosilanes as Synthetic Platform Toward Functionalized Silanes
0609
Enzyme-Catalyzed Selective [2+2] and [4+2] Cycloadditions
0610
Small Molecule Activation with New Constrained Borylene
0611
Bifunctional Superbases Catalyze the Addition of Nitroalkanes to α,β-Unsaturated Esters

Innovative Drug Discovery and Development

z0613
All PDFs of this category
0613
Alcohols as Substrates for Metallaphotoredox-Catalyzed C(sp3)–C(sp3) Cross-Coupling
0614
Leveraging Biocatalysis and a Reductive Acetal Opening to Access Nemtabrutinib
0615
Discovery of a Selective pan-FGFR Inhibitor Approved for Treatment of Cholangiocarcinoma
0616
On-Protein Radical Cysteine Editing
0617
Chemoselective Synthesis of Asymmetric Disulfides
0618
Overcoming Prostate Cancer Drug Resistance Through a New Druggable Site on the Androgen Receptor
0619
A PhI CXCR3 Antagonist Making Progress in its Clinical Development for Inflammatory Disorders
0620
Traceless Late-Stage Modification for Protein Delivery
0621
A New Benzene Synthesis for 1,3- and 1,3,5-Substitution
0622
Synthesis of a HPK1 Inhibitor through C–N Coupling and Biocatalysis
0623
Isolation of Diethanolamine Boronic Ester Improves Synthesis to AZD5718
0624
On-Demand PROTAC Scavenging Using Click Chemistry
0625
Determining Phase Separation Dynamics with an Automated Image Processing Algorithm

Peptide Chemistry

z0627
All PDFs of this category
0627
Fe-Catalyzed Alkylation of Glycine Derivatives
0628
Synthesis of β-Aminocyclobutanecarboxylic Acid Derivatives
0629
Synthesis of Unnatural Peptides by Deaminative Reductive Cross-Coupling Reactions
0630
Electrochemical N-Methyl β-Amino Acids Synthesis
0631
Co-Catalyzed Dideuterated α-Amino Aicd Synthesis
0632
Electrochemical Synthesis for Phosphorylated Amino Acid Derivatives
0633
Development of Mild Conditions for the Deprotection of the tert-Butoxycarbonyl Protecting Group
0634
Synthesis of Amino Acid Derivatives via Free Carbene Insertion

Flow Chemistry

z0635
All PDFs of this category
0635
Enantioselective Nickel-Catalyzed 1,4-Addition of Malonates with Nitroalkenes

Erratum

0636
Desrosiers, J N; Xu, Y; Kosnik, S C; Qu, B; Lao, K S; Senanayake, C H; Zhang, Y: Erratum: Multigram Synthesis of pivZPhos Ligand