DOI: 10.1055/s-00000131

Synfacts

Issue 08 · Volume 19 · August 2023 DOI: 10.1055/s-013-57879

Synform

A133
Zanda, Matteo: SYNFORM ISSUE 2023/08

Synthesis of Natural Products

z0741
All PDFs of this category
0741
Synthesis of (–)-Retigeranic Acid A
0742
Synthesis of (–)-Alloaristoteline
0743
Synthesis of (+)-Aberrarone
0744
Synthesis of (±)-Sculponin U
0745
Synthesis of (±)-Daphnillonin B
0746
Total Synthesis of (–)-Alstomutinine C
0747
Total Synthesis of (±)-Khusimone

Synthesis of Heterocycles

z0749
All PDFs of this category
0749
Alternative to Ozonolysis for the Oxidative Cleavage of Olefins
0750
General, Scalable Synthesis of 3-Azabicyclo[3.1.1]heptanes
0751
Synthesis and Reactivity of 4H-Dewar Pyridines as Rigid Bioisosteres for 4-Substituted Piperidines
0752
Building Highly Substituted Furyl Boronates via Carbene Boryl Migratory Insertion
0753
Synthesis of P-Heterocycles from Unsaturated Phosphonites with C(sp2)-Electrophiles
0754
Palladium-Catalyzed Synthesis of Indoles from ortho-Nitrostyrene and Formic Acid
0755
Computational Studies on the Reaction Pathways of 1,2-Azaborinine with Unsaturated Organic Compounds
0756
Photocatalyzed Access to Protected Trifluoromethyl Ketones through C–C Bond Formation
0757
Ironing-Out Photodecarboxylation: Cross-Nucleophile Coupling Mediated by Iron Salts
0758
Efficient Ring Opening Kinetic Resolution of 2,3-Aziridinyl Alcohols with Dinuclear Zinc Complexes
0759
Sustainable Syntheses of Pyridines and Quinolines
0760
Radical Ring Expansion of Hemiketal Hydroperoxides to Macrolactones

Synthesis of Materials and Unnatural Products

z0761
All PDFs of this category
0761
Topologically Chiral Nanohoops
0762
Stereoselective Synthesis of Tetraarylethylene
0763
Functionalizing High-Energy Density Cages
0764
Isolable Arene-Fused 1,2-Diborete Biradicaloid
0765
Facile Functionalization of Bicyclo[1.1.1]pentane
0766
Direct C–H Borylation of Trityl Radical
0767
Mechanical Chirality
0768
Joining Inorganic Cages into Polymers
0769
Sliding Pseudorotaxane Catalysts
0770
Enantioselective Access to Carbohelicenes
0771
[2+2+2]-Enabled Organic Covalent Cages
0772
Three-State Photochromism

Metals in Synthesis

z0773
All PDFs of this category
0773
The Catellani Reaction meets C–H Activation: Synthesis of 1,3-Disubstituted Planar Chiral Metallocenes
0774
Unsymmetrical Ketone Synthesis via Selective Nickel-Catalyzed Reductive Carbonylation
0775
Leveraging Strain-Release in Dearomative Photocycloadditions of Bicyclic Aza-Arenes
0776
Asymmetric Synthesis of Unnatural Monoterpene-Linked Heterocycles
0777
Novel Acyl Suzuki–Miyaura Coupling Between N-Hydroxybenzotriazole Esters and Boronic Acids
0778
Cobalt-Catalyzed Cleavage of Tertiary Allylic Alcohols into Ketones
0779
Benzopyrano[4,3-b]pyridine Synthesis via Copper-Catalyzed Oxidative Reaction
0780
Turning Homoallylic Alcohols into Aliphatic Ketones under Nickel Catalysis
0781
Alkynylative Lactonization of 2-Vinylbenzoates to 3-Substituted Isochroman-1-ones
0782
Synthesis of Bicyclic α,β-Unsaturated γ-Lactams through an Intramolecular Reductive Pauson–Khand Reaction
0783
Silanols as Carbon-Centered Radical Precursors: Photo-induced Cerium-Catalyzed C(sp3)–Si Bond Cleavage
0784
Ru-Catalyzed Synthesis of Polysubstituted Arenes via a Directing Group Relay Strategy and C–H Functionalization
0785
Synthesis of Arylated Allenyl Monofluorides via Copper-Catalyzed Defluoroarylation of gem-Difluoroallenes
0786
Enantioselective Three-Component Sulfonylalkenylation of Styrenes to Access β-Chiral Sulfones
0787
Access to Aryl and Vinyl Halides Enabled by Nickel-Catalyzed Halogenation of Thianthrenium Salts
0788
Nickel- and Neodymium-Catalyzed Asymmetric Synthesis of Hantzsch Esters
0789
Two-Step One-Carbon Homologation/Ring Expansion of Ketones
0790
Palladium-Catalyzed Regio- and Enantioselective Remote Diacetylation of Internal Olefins
0791
Synthesis of Bis-Heterocycles via Gold-Catalyzed Domino Cyclization Reactions
0792
Co-Catalyzed Three-Component Synthesis of N-Pyrimidyl Indoles
0793
Iridium-Catalyzed Synthesis of N–N Biaryl Atropisomers via Asymmetric C–H Activation with Acrylates
0794
Rhodium-Catalyzed Stereoselective Synthesis of E-Dienyl Esters from Acetylene and Carboxylic Acids
0795
Electrified: Electroreductive Cobalt-Catalyzed C(sp2)–Ge and C(sp3)–Ge Bond Formation
0796
Synthesis of N–O-Linked Glycosides via Stereospecific Pd-Catalyzed Reaction
0797
Pd/Visible Light-Promoted Head-to-Tail Hydroalkenylation of Alkenes
0798
Pd-Catalyzed Synthesis of Bridged Polycyclic Lactams via Intermolecular Carbonylative Dearomatization
0799
The Saegusa–Ito Oxidation of Silyl Enol Ethers to α,β-Unsaturated Carbonyl Compounds

Polymer-Supported Synthesis

z0801
All PDFs of this category
0801
Oxidative Cleavage and Ammoxidation of C–S Bonds by Cobalt/N-Doped Carbon Catalyst
0802
Photocatalytic Methylation of (Iso)quinoliniums with DMSO
0803
Iminyl Radical-Mediated Reactions Using a Dimeric Cu-BINAP Complex Supported on Pillar-Layered MOF
0804
Arylation of Elemental Sulfur Forming Diaryl Disulfides by a Single-Atom Copper Catalyst on Ceria
0805
Suzuki–Miyaura Coupling Using Flow-Through Membrane Reactor
0806
Transfer Hydrogenation of N-Heteroarenes with a COF-Anchored Rhodium Bipyridine Catalyst in Water
0807
N-Formylation of Aliphatic Primary and Secondary Amines with CO2/H2 by Cu2O/Cu Supported on Alumina
0808
Photocatalytic Arylation of Quinoxalin-2(1H)-ones with Arylhydrazines by g-C3N4 and NaI
0809
Regio- and Stereoselective Hydroboration of Enallenes by Palladium Nanoparticles Immobilized on Cellulose
0810
Synthesis of Substituted Pyridines Using a Ni(II)−Picolyamine Complex Supported on SiO2/Fe3O4
0811
Gold Nanoparticles Supported on Ti or Zr Oxide for Deoxygenative Silylation of C(sp3)–O Bonds

Organo- and Biocatalysis

z0813
All PDFs of this category
0813
Chiral-Phosphoric-Acid-Catalyzed Asymmetric Dearomatization of Indole Derivatives
0814
CO2 Reduction by a Membranous, Metal-Free, Triazine- and Imine-Containing Covalent Organic Framework
0815
Enantioselective Nucleophilic Desymmetrization of Phosphonate Esters Using Bifunctional Superbases
0816
Biocatalysis and Photocatalysis Joining Forces in a Stereoselective Method for Synthesis of Sulfones
0817
Bifunctional Iminophosphorane Catalyst Enables Challenging Intramolecular Oxa-Michael Reactions
0818
An Effcient Organocatalytic Chlor-Alkali Process
0819
Photocatalytic Z to E Isomerisation of Fluorinated β-Borylacrylates
0820
Imidodiphosphorimidates(IDPis) Permit Asymmetric Synthesis of cis-Tetrahydrocannabinoids
0821
Engineered Photoenzyme Overrides Traditional Regioselectivities in the Alkylation of Indoles

Innovative Drug Discovery and Development

z0823
All PDFs of this category
0823
Development of the Commercial Manufacturing Process for Nirmatrelvir in 17 Months
0824
Selective Boronate Addition to Pyridiniums
0825
Photoproximity Labeling of Proteins
0826
Discovery of ACT-774312: A Potent and Selective CRTH2 Receptor Antagonist
0827
Tenofovir Prodrug Synthesis Inspires Novel C–P Bond-Forming Method
0828
Discovery of the First OX1R-Selective Agonist: YNT-3708
0829
RAFT Polymer−Antibody Conjugation of a Therapeutic Anti-EGFR Antibody to Increase Tumor Uptake In Vivo
0830
Design and Synthesis of the First-in-Class MC4R Antagonist, PF-07258669 with [4,5]-Spirocyclic Core
0831
A Modular Platform for Covalent, Photoswitchable Control over Enzyme Activity
0832
One-Pot Preparation of Thioamide Peptides
0833
Scalable Synthesis of KRAS G12C Inhibitor GDC-6036
0834
Understanding the Impact of Impurities in Peptide Coupling Reagents
0835
No Need to Feed: Complete Integration of Carbene-Transfer Chemistry into Biosynthesis

Peptide Chemistry

z0837
All PDFs of this category
0837
Efficient Method for Cyclic Peptide Synthesis Mediated by Acylammonium Species
0838
Ir-Catalyzed Functionalization of Alkyl Silane with Benzosultam
0839
Organocatalyzed Synthesis of Cyclized Amino Acids with Cyanocoumarin
0840
Copper-Catalyzed Synthesis of α,α-Disubstituted Amino Acid Derivatives
0841
Enantio- and Diastereoselective Annulation to Form Fused Amino Acid Derivatives
0842
Synthesis of anti-β-Amino Organoborons via Radical Hydroboration
0843
AlMe3-Mediated One-Pot Peptide Bond Formation of N- and C-Terminal Amino Acids
0844
Diboronic Acid Anhydride-Catalyzed Synthesis of Serine or Threonine Containing 2,5-Diketopiperazines
0845
Synthesis of Unnatural Amino Acids from in situ Generated Glycine Cation Equivalents
0846
W-Catalyzed C(sp3)–H Alkylation of Valine

Flow Chemistry

z0847
All PDFs of this category
0847
Photochemical [2+2] Cycloaddition between Alkynes and Maleimides Using Continuous Flow
0848
Microwave-Assisted C–C Bond Formation to Access Fused-Ring Compounds