DOI: 10.1055/s-00000131

Synfacts

Issue 10 · Volume 19 · October 2023 DOI: 10.1055/s-013-58263

Synform

A167
Zanda, Matteo: SYNFORM ISSUE 2023/10

Synthesis of Natural Products

z0955
All PDFs of this category
0955
Total Synthesis of (–)-Cephinoid P
0956
Total Synthesis of (+)-Aspidospermidine
0957
Synthesis of (–)-Eugenial C
0958
Synthesis of (+)-Pleiocarpamine and (+)-Bipleiophylline
0959
Synthesis of (–)-Polyavolensinol and (–)-Greenwaylactam A
0960
Total Synthesis of (+)-Lancilactone C
0961
Synthesis of (±)-Nominine

Synthesis of Heterocycles

z0963
All PDFs of this category
0963
Cu-Mediated Cyclization to Form 1H-Indazoles
0964
Synthesis of Highly Substituted BN-9,1-Naphthalenes from BN-Butafulvenes
0965
Revalorization of Nitrous Oxide for Use as an Oxygen-Transfer Reagent
0966
Cp*Co(III)-Catalyzed Synthesis of Isoquinolones via Regioselective [4+2] Annulation of N-Chlorobenzamides
0967
Secondary Amines from Ammonia Surrogate – Aminopyridinium Salts
0968
Application of Strained Heterocycles as Electrophiles in Ni/Ir-Catalyzed Cross-Couplings
0969
Synthesis of Substituted 2-Oxabicyclo[2.1.1]hexanes via [2π+2σ] Cycloadditions with Bicyclobutanes
0970
Mechanism-Driven Development of a Novel Amide Directing Group for Directed C–H Functionalization
0971
Validation, Development and Execution of an Automated Protocol for C–C Cross-Couplings
0972
Access to Spiro-oxetane Oxindoles via DBU-Catalyzed Activation of Allenoates
0973
General, Direct Ni-Catalyzed Cross-Coupling of Tertiary Synthons with Heteroaryl Halides

Synthesis of Materials and Unnatural Products

z0975
All PDFs of this category
0975
Introducing Double Bonds to Polyolefins via Retro-Diels–Alder Reaction
0976
One-Pot Synthesis of Benzo[c]phenanthridines
0977
Reactivity of 1,2,3-Triazines and the Oxides
0978
Difunctionalization Applied to Polymerization
0979
Stoichiometry-Controlled Boration of Terminal Alkynes
0980
Phenols from [3+3] Cycloaddition
0981
All-Fused Rubicene Dimers and Trimers
0982
1,3-Dipolar Cycloaddition Involving Arenes
0983
Hydrolytically Stable Molecular Cage
0984
Benzo[a]aceanthrylene from [4+2] Cyclization
0985
Large Circumacene with a Pentacene Center
0986
Negatively Curved Nanocarbons with Heptagon Modules

Metals in Synthesis

z0987
All PDFs of this category
0987
Silver(I)-Catalyzed Rearrangement of 1,4-Disubstituted Cubanes to 1,3- or 2,6-Disubstituted Cuneanes
0988
Pd/Charcoal Catalyzed Reduction of Vinyl Geminal Diboronates
0989
Copper-Catalyzed Difluoroalkylation of Silyl-Enol Ethers
0990
Regioselective Three-Component Intermolecular Dialkylation of Styrenes Enabled by Nickel Catalysis
0991
Enantioselective Three-Component Synthesis of Trifluoromethylated Propargylic Ethers and Anilines
0992
Iridium-Catalyzed Atroposelective Synthesis of Silylated 2-Arylisoquinolines via C–H Activation
0993
ε-exo-Alkylidene ε-Lactones Synthesis via Cooperative Gold/Zinc-Catalyzed 7-exo-dig Cyclization
0994
Oxoamination of Terminal Alkenes under Visible-Light-Induced Ruthenium Catalysis
0995
Iridium-Catalyzed Asymmetric Allylic Alkylation via 1,2-Boryl Migration and Dynamic Kinetic Resolution
0996
Rh-Catalyzed Unsymmetrical Heterobiaryl Synthesis via a Dual C–H Activation Cross-Coupling Process
0997
Rapid Construction of Carbazole Frameworks through Gold-Catalyzed Cyclizations and [3+2] Annulation
0998
Iron-Catalyzed C(sp3)–H Phosphorylation Enabled by Photoinduced Ligand-to-Metal Charge Transfer
0999
Photoinduced Copper-Catalyzed Borylation of Non-Activated Alkanes
1000
Pd-Catalyzed Synthesis of Spirocyclohexaneindolenines from Bromoarene-Tethered Indoles and Alkynes
1001
Bismuth-Catalyzed Decarboxylative Amination of α-Amino Alkyl Phthalimide Esters with N-Heterocycles
1002
Palladium/Copper Bimetallic-Catalyzed Direct C–H Heteroarylation of N-Methylpyridinium Salts
1003
Nickel/Photoredox-Catalyzed Thioesterification of Carboxylic Acids Enabled by Sensitized Electron Transfer
1004
Cobalt-Catalyzed Reductive Coupling of Nitroarenes and Formaldehyde to N,N'-Diarylethane-1,2-diamines
1005
Ag-Catalyzed Synthesis of Functionalized Benzo[d]azepines
1006
Access to Azacycles by Cobalt-Catalyzed Asymmetric Cross-Electrophile Coupling
1007
Ruthenium-Catalyzed Intramolecular Cycloaddition of Cyclopropenynes and Cyclopropendiynes
1008
Negishi Cross-Coupling Using Cobalt
1009
Rhodium-Catalyzed Borylative Cyclization of Enynes
1010
Synthesis of α-Fluoro-β-Ketophosphonates through Rh-Catalyzed Hydration/C–F Bond Cleavage
1011
Coupling of Ketyl and Alkyl Radicals Generated under Photoredox Cooperative NHC/Palladium Catalysis
1012
Co-Catalyzed Three-Component 1,2-Dialkylation of Alkenes Using Novel Salt-Stabilized Alkylzinc Pivalates
1013
Sequential Borane- and Pd-Catalyzed C3-Allylation of Pyridines via a DYKAT Process

Polymer-Supported Synthesis

z1015
All PDFs of this category
1015
Hydrogenation of N-Heterocycles Using Frustrated Lewis Pairs Incorporated in NU-1000 MOF
1016
Hydrogenation of Arenes by Cobalt Nanoparticles Supported on Biomass-Derived Carbons
1017
Reduction of Nitroarenes to Azoxy-, Azo-, and Hydrazo Compounds Promoted by Bismuth Porphyrin MOF
1018
Visible-Light-Induced Cyclization of N-Phenyl-benzothioamides Using β-Ketoenamine-Linked COF
1019
Bifunctional Catalysts with Core–Shell Distributed ZrO2/Co NPs for Hydrogenation–Formylation of Nitroarenes
1020
Preparation of Silica-Gel-Supported Photocatalysts
1021
Photochemical Synthesis of Benzimidazoles Promoted by Palladium-Decorated ZnO Nanosheets
1022
Photocatalytic C–H Amination of Arenes by a Ruthenium Complex on Faujasite-Type Zeolite
1023
Photocatalytic Aerobic Oxidations by a 2D Microporous Covalent Organic Framework
1024
A COF-Supported Cd(II) Catalyst for Carboxylative Cyclization of CO2 with Propargylamines
1025
Photocatalytic Dehydrogenative [4+2] Annulation of Benzothioamides with Alkynes Using g-C3N4
1026
Ni-Catalyzed C–C Bond Forming Cross-Coupling of Aryl/Alkyl Halides with a Quantum Dots Photocatalyst

Organo- and Biocatalysis

z1027
All PDFs of this category
1027
Synthesis of Eight-Membered Carbocycles by (I)/I(III)-Catalyzed Diene Cyclization
1028
Ene-Reductase Outcompetes Hydrogen Atom Transfer in Asymmetric Carbohydroxylation of Alkenes
1029
Photoredox Catalysis Enables New Synthetic Route Toward Oxetanes
1030
Cytochrome P450-Derived Ketone Synthase Enables Regioselective Aerobic Oxidation of Arylalkenes
1031
Enantioselective Protio-Semipinacol Rearrangement of Vinyl Cyclopropanols
1032
N-Triflyl Phosphoramide Catalyzed Atroposelective C–C Cross-Coupling of 1-Azonaphthalenes
1033
Photosensitized O2Permits a Versatile Cyclopropanation Reaction
1034
Direct, Additive-Free Electrochemical Dehydrative Esterification of Carboxylic Acids and Alcohols

Innovative Drug Discovery and Development

z1035
All PDFs of this category
1035
Stereoselective Robinson Annulation Enables Access to Potent and Selective Salvinorin Analogs
1036
Converting DNA-Encoding Ligands into BRET Probes
1037
Identifying the Risk of Formation of Nitrosamines and Other Potentially Mutagenic Impurities during API Manufacture Using In Silico Risk Assessment
1038
A Pathway-Selective Photoswitch for Understanding Cannabinoid 2 Receptor
1039
Late-Stage Aryl C–H Bond Cyclopropenylation with Cyclopropenium Cations
1040
Optimization of Cyclic Peptide Hits to Identify Clinical KRAS-SOS1 PPI Inhibitor, LUNA18
1041
Toward Improved On-Target Safety: Discovery of Potent, Short Half-Life Macrocyclic Inhibitors of Mcl-1
1042
Design and Synthesis of MK-8768: a Potent and Selective mGluR2 Negative Allosteric Modulator
1043
Transition Metal-Free syn-Dihydroxylation via Interrupted Ozonolysis
1044
Cubane and Cyclooctatetraene Used as Bioisosteres in Drug Development
1045
Initiation of Fluorescence and Bioactivity Using UV Light Photocage on PI3K Inhibitor
1046
Synthesis of N-Acylsulfonamide Derivates: New Sulfa Drug Analogues by Sulfo-Click Reaction
1047
CF2X, a New Halogen Bond Donor Motif with Potential in Drug Design
1048
Amide Derivatization Through Amino Acid Insertion
1049
para-Selective Functionalization of Pyridines

Peptide Chemistry

z1051
All PDFs of this category
1051
Rh-Catalyzed Maleimidation of Trp-Including Peptides
1052
One-Pot Enantioselective Synthesis of α‑Amino Acid Esters
1053
Synthesis of Small Cyclic Peptides Containing N-Methyl and β-Amino Acids
1054
Asymmetric Synthesis of α-Sulfinamido Trithioformates and Transformation to Peptides
1055
Co-Catalyzed Enantioselective Hydrogenation to Form Indazole-Containing Amino Acids
1056
Palladium-Catalyzed Late-Stage Functionalization of Phenylalanine and Phenylalanine Derived Peptides
1057
Cu-Catalyzed Three-Component Coupling for the Synthesis of α-Aryl α-Amino Acid Derivatives
1058
Macrocyclization of Oligopeptides via Introduction of a Hypervalent Iodine Reagent
1059
Direct Catalytic Asymmetric Synthesis of α-Alkylated α,α-Disubstituted Amino Esters
1060
Photocatalyzed C–H Functionalization of Trp-Including Peptides
1061
Ring-Opening of Aziridine Carboxylates for the Synthesis of Tryptophan Derivatives

Flow Chemistry

z1063
All PDFs of this category
1063
Atroposelective Dual Catalysis in Flow
1064
A Continuous-Flow Electron-Poor-Arene Dearomatization via Photocatalyzed Cycloaddition