DOI: 10.1055/s-00000131

Synfacts

Issue 12 · Volume 19 · December 2023 DOI: 10.1055/s-013-58592

Synform

A194
Zanda, Matteo: SYNFORM ISSUE 2023/12

Synthesis of Natural Products

z1173
All PDFs of this category
1173
Synthesis of (–)-Zygadenine
1174
Syntheses of ent-(–)-Njaoamine C
1175
Total Synthesis of (–)-Cotylenol
1176
Total Synthesis of (–)-Silicine and (–)-20-Episilicine
1177
Total Synthesis of (±)-Neocaesalpin A
1178
Chemoenzymatic Synthesis of Cylindrocyclophanes A and F and Merocyclophanes A and D
1179
Total Synthesis of (±)-Antheridium-Inducing Factor AAn

Synthesis of Heterocycles

z1181
All PDFs of this category
1181
Regiodivergent C–H Arylation of Thiophenes
1182
Doebner Hydrogen-Transfer Reaction to Access Electron-Deficient Quinolines
1183
Cobalt-Catalyzed Olefin Cyclopropanation via Masked Dialkyl Diazomethanes
1184
TBAI-Mediated Synthesis of Methylsulfonyl Oxazoles from Propargylic Amides
1185
Direct Carbon for Nitrogen Replacement Reaction to Access Functionalized Pyridines
1186
Palladium-Catalyzed C–H Arylation of Functionalized Pyrazoles/Triazoles and Imidazoles
1187
Fused Piperidine Derivatives Featuring Stereogenic CF3 Substitution
1188
Stereoselective Cascade Reaction for the Synthesis of Chiral Fused Diazaheterocycle Scaffolds
1189
Scalable Synthesis of Silacyclohexanones for Silaheterocycles Construction
1190
Modular, Chiral-Auxiliary-Mediated Synthesis of Sterically Constrained β-Amino Acid Derivatives
1191
Synthesis of Functionalized Pyrrolidinones via Smiles–Truce Cascade
1192
Rhodium(III)-Catalyzed Synthesis of Unsymmetrically Substituted 2,2'-Dipyridyl Amines Using 1,2,4-Trizoles

Synthesis of Materials and Unnatural Products

z1193
All PDFs of this category
1193
A Figure-of-Eight Molecular Shuttle
1194
Benzoselenophenes from Elemental Selenium
1195
A Trisradical Tricationic Cage
1196
Let Light Do the Trick
1197
Sulfur-Free Cationic RAFT
1198
Palladium-Catalyzed Decarbonylative Intermolecular Annulation
1199
Multi-Component Synthesis of 2,3,6-Substituted Pyridines
1200
Photodegradable Vinyl Polymers from Living Cationic Ring Opening
1201
C–H Activation with Polyolefins by Photoinduced Catalysis
1202
Three-Dimensional Covalent Organic Framework
1203
Chalcogen-Extrusion from Nanographene
1204
Alkylated Boroles from Aluminum–Boron Exchange

Metals in Synthesis

z1205
All PDFs of this category
1205
Iridium-Catalyzed Enantioselective Cascade Allylic Etherification/[2+2] Photocycloaddition
1206
Cobalt-Catalyzed Asymmetric Alkynylative Ring Opening of Oxabicyclic Alkenes
1207
Dealkenylative C(sp3)–N Cross-Coupling of Alkenes and Amines by Merging Ozonolysis and Copper Catalysis
1208
A Nickel-Catalyzed Alkene Dicarbofunctionalization Approach Avoiding Carbon–Metal Intermediates
1209
Cu-Catalyzed Synthesis of Oxazoles via [3+2] Annulation/Olefination Sequence
1210
Catalytic Alkyne-Carbonyl Ring-Closing Metathesis to Make γ-Butenolides from Propargyl α-Ketoesters
1211
Enantio- and Diastereoselective Cyclopropanation of Alkenes by Iron(III)-Based Metalloradical Catalysis
1212
Palladium-Catalyzed C–H Functionalization of Triaryl Phosphates via Eight-Membered Palladacycle
1213
Visible-Light Photocatalytic [2+2] Cycloaddition of 1,5-Hexadienes to Bicyclo[2.1.1]hexanes
1214
Lewis Acid Assisted Double CO2 Fixation in Nickel-Catalyzed Carboxylative Cross-Electrophile Coupling
1215
Copper Catalyzed Formal [3+2] Cycloaddition Between Aziridines and Silyl Dienol Ethers
1216
Synthesis of 2-Amino Aromatic Acetic Acid Derivatives via Rhodium-Catalyzed C–H Carboxymethylation
1217
Alcohol-Directed sp3 C–H Arylation Catalyzed by Palladium
1218
Hydroarylation Strategy Towards Enantioenriched C–N Vinylindole Atropoisomers
1219
Blue’s Complementary: Photoredox/Nickel-Catalyzed C(sp2)–C(sp3) Cross-Coupling under Orange Light
1220
Chromium-Catalyzed Cross-Electrophile Coupling of Hydrochlorosilanes with Aryl Pivalates
1221
Asymmetric Reductive Coupling of Alkynes and Imines via Cobalt-Catalyzed Formation of Zinc Metallacycles
1222
Gold-Catalyzed Synthesis of Naphthoate Derivatives Via Cascade [5+1] Annulation
1223
Direct C(sp2)–H ortho-Methoxylation of Aryl Halides by a Catellani-Type Reaction
1224
Asymmetric and Regiodivergent Synthesis of Silyl-Containing Homoallylic Alcohols Using Cu Catalysis
1225
Asymmetric Synthesis of Masked Arylglycine Esters via Pd-Catalyzed Arylation of Schöllkopf Bis-Lactim Ethers
1226
Synthesis of 2-Amino-3-Formylated Chromones via Pd Domino Catalysis
1227
Amination of Aryl Bromides under Nickel/Mechano-redox Catalysis Using Ball-Milling Technique
1228
Synthesis of 1,3-Oxazine or Hydropyrimidine Derivatives via Palladium-Catalyzed [4+2] Cycloaddition
1229
Rhodium Catalyzed Desymmetrization of Metallocenes – A Conjugate Addition Cyclization Cascade
1230
The Reetz Alkylation: Direct Geminal Dimethylation of Ketones Using Organotitanium Chemistry

Polymer-Supported Synthesis

z1231
All PDFs of this category
1231
Oxidation of C(sp3)–H and C=C Bonds Promoted by Iron Complex Immobilized on COF Nanospheres and Film
1232
Decarboxylative Coupling of N-Hydroxyphthalimide Esters with Disilanes or Diborons with Au Nanocatalyst
1233
Transfer Hydrogenation of Azoarenes to Hydrazoarenes by Ammonia Borane Catalyzed by Au/TiO2
1234
Carbonylative Coupling of Aryl Boronic Acids by Pd NPs within Melamine Dendron and Fibrous Nano-Silica
1235
Rhodamine B Encapsulated in a Metal–Organic Cage for Photocatalytic Oxidation in Aqueous Media
1236
Photocatalytic Hydroalkylation and Oxidative Coupling of Phenylacetylenes Catalyzed by a Cu@MOF Composite
1237
Hydrogenation of Quinolines Using Fully Exposed Iridium Clusters Supported on Sulfur-Doped Carbon
1238
Electrocarboxylation of Aryl Bromide with CO2 by Bifunctional Cu/Ag Catalysts
1239
Catalytic Asymmetric Oxirane Ring Opening with Chirally-Modified PCN-222 MOF
1240
Transfer Hydrogenation of Azides by a Single-Atom Cobalt Catalyst
1241
Photocatalytic Oxidation Reactions Using Phenothiazine-Anchored CTFs

Organo- and Biocatalysis

z1243
All PDFs of this category
1243
Electrophotocatalytic Generation of Unstabilized Ketyl Radicals and their Coupling to Alkenes
1244
Axially Chiral Biaryl Siloxanes Synthesized through Asymmetric Si–CAryl Bond Functionalization
1245
Enzymatic Enantioselective Amination Using Hydroxylammonium Hydrochloride as Nitrogen Source
1246
Lewis Acid Catalyzed Deoxyfluorination of Alcohols
1247
Organocatalytic Direct Acylation of Alkanes
1248
Enantioselective Isomerization of Substituted Bicyclo[1.1.0]butanes into Cyclobutenes
1249
Photocatalytic Deracemization Enables the Synthesis of Chiral 2,5-Diketopiperazines
1250
Chiral Diselenides – Catalysts for the Enantioselective Synthesis of Phosphorus-Stereogenic Compounds
1251
A Photocatalytic Sulfinamide Synthesis Platform Provides Access to Sulfonamides and Sulfonimidamides

Innovative Drug Discovery and Development

z1253
All PDFs of this category
1253
4-Selective Azaarene Fluorination
1254
Visualizing New Proteins with THRONCAT
1255
Total Synthesis of Tetrachlorovancomycin
1256
One-Pot Formal Carboradiofluorination of Alkenes for PET Imaging Probe Development
1257
Substrate Plasticity Enables Group-Selective Transmetalation: Catalytic Stereospecific Cross-Couplings of Tertiary Boronic Esters
1258
A pH and Ca2+ Tolerant Ratiometric Mg2+ Sensor
1259
Accessing Potential Anti-Obesity Drug via Total Synthesis
1260
cis-Active Photoswitchable CB2-Receptor Agonist
1261
Aerobic Oxidation Using Cu/TEMPO as an Alternative to Toxic DDQ-Mediated Reaction
1262
Flexible Ether-Bearing Emn-BridgePhos Ligands for Enantioselective Desymmetric Hydrogenation
1263
Fragment Coupling Approach Enables Convergent Access to (–)-Cyclopamine
1264
Sulfonium Salt Reagents for the Introduction of Deuterated Alkyl Groups in Drug Discovery
1265
Strategy to Improve Half-Life of DGAT2 Inhibitor Ervogastat: Discovery of PF-07202954
1266
Aryl (β,β,β-Trifluoro)-tert-Butyl: A Candidate Motif for the Discovery of Bioactives
1267
Palladium-Catalyzed Preparation of Indolyl-C-Glycosides
1268
CPA-Catalyzed Synthesis of Chiral α,α-Diaryl Ketones from Unactivated Alkyenes
1269
Access to Normal and Abnormal Neocannabinoids via Control of Friedel–Crafts Reaction Time

Peptide Chemistry

z1271
All PDFs of this category
1271
Peptide Cleavage Reaction at the C-Terminal Arg Site
1272
Amide Bond Formation Using Triflylpyridinium as Coupling Reagent
1273
Thiol-Labile Amino Protecting Group that Suppresses the Epimerization in Peptide Synthesis
1274
Enantio- and Diastereoselective Synthesis of β-Aminoamides Catalyzed by a Chiral NiH Complex
1275
Fe-Catalyzed Alkylazidation of Alkenes for the Synthesis of α-Azido α-Amino Esters
1276
Pd-Catalyzed Synthesis of (Z)-Trisubstituted Allylic Amino Acids
1277
Esterification of Amino Acids by Using TCFH as Reagent
1278
Benzylic Lithiation Reaction for the Synthesis of Unnatural Amino Acids

Flow Chemistry

z1279
All PDFs of this category
1279
Investigating Ozone Solubility in Organic Solvents for Use in Flow Ozonolysis Protocols
1280
Flash Thermal Racemization for Chemoenzymatic Dynamic Kinetic Resolution of Chiral Amines