Gram-scale Synthesis of (±)-Tylophorine

Dattatraya P Masal; Srinivasa Reddy

doi:10.1055/a-2351-4828

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Synlett
DOI: 10.1055/a-2351-4828

letter

Gram-scale Synthesis of (±)-Tylophorine

Dattatraya P Masal

¹Organic Chemistry, CSIR National Chemical Laboratory, Pune, India (Ringgold ID: RIN29616)

,

Srinivasa Reddy

²Organic Synthesis & Process Chemistry, Indian Institute of Chemical Technology CSIR, Hyderabad, India (Ringgold ID: RIN62391)

› Author AffiliationsSupported by: University Grants Commission Fellowship
Supported by: DST-SERB JCB/2021/000022/SSC

› Further Information

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Herein, we report a practical scalable synthesis of a natural product (±)-tylophorine using an operationally simple, protecting group free synthetic route from readily accessible starting materials. Synthesis of cyclic N-acetyl diester compound through cyclization, followed by two key steps decarboxylation and Clemmensen reduction to access the target molecule.

Publication History

Received: 08 May 2024

Accepted after revision: 24 June 2024

Accepted Manuscript online:
24 June 2024

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