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Synthesis
DOI: 10.1055/a-2508-3790
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Nickel(II)-Catalyzed Cycloisomerization of 1,6-Dienes

Zhongjian Du
1   Chemistry, Hefei University of Technology, Hefei, China (Ringgold ID: RIN558979)
,
Chenlei Ji
1   Chemistry, Hefei University of Technology, Hefei, China (Ringgold ID: RIN558979)
,
Xu Wang
1   Chemistry, Hefei University of Technology, Hefei, China (Ringgold ID: RIN558979)
,
Sijian Zhang
1   Chemistry, Hefei University of Technology, Hefei, China (Ringgold ID: RIN558979)
,
Zhenyu Wang
2   Caijiashan Fine Chem Pk, Anhui Province Key Lab of Green Manufacturing in Phosegene Industry, Xinhang, China
,
Yang'en You 
1   Chemistry, Hefei University of Technology, Hefei, China (Ringgold ID: RIN558979)
› Author AffiliationsSupported by: National Natural Science Foundation of China 22401070
Supported by: the Fundamental Research Funds for the Central Universities of China PA2024GDSK0102
Supported by: Anhui Provincial Postdoctoral Research Fund 2023B666
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A nickel-catalyzed protocol for the cycloisomerization of 1,6-dienes has been developed. Using commercially available NiBr₂ and PPh₃ as catalysts, Zn as a reductant, and ZnI₂ as an additive, the methodology efficiently converts various 1,6-dienes into pyrrolidine derivatives with excellent yields and high selectivity



Publication History

Received: 02 December 2024

Accepted after revision: 26 December 2024

Accepted Manuscript online:
03 January 2025

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