Download PDF
Exp Clin Endocrinol Diabetes 1996; 104: 182-183
DOI: 10.1055/s-0029-1211664
Part III — Posters
NIDDM and Insulin Resistance
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

P-120: Insulin resistance is related to defects in insulin receptor tyrosine kinase activation in Pima Indians

J. F. Youngren* , I. D. Goldfine* , R. E. Pratley†
  • * Diabetes and Endocrine Research, Mt. Zion Medical Center of UCSF, San Francisco, CA
  • † Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ
Further Information

Publication History

Publication Date:
15 July 2009 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

Our data indicate that in vivo insulin resistance in non-diabetic Pima Indians is associated with a decreased ability for immunocaptured skeletal muscle insulin receptors to au-tophosphorylate in vitro. In addition, although increasing obesity in these subjects was associated with both decreased insulin action and insulin receptor tyrosine kinase activation, there was still a significant correlation between insulin receptor activation and Mlow independent of % fat. This suggests that the intrinsic insulin resistance of Pima Indians not attributable to obesity is also associated with defects in insulin receptor function.