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DOI: 10.1055/s-0031-1299793
Genetics Meets Environment: Evaluating Gene–Environment Interactions in Neurologic Diseases
Publication History
Publication Date:
21 January 2012 (online)
ABSTRACT
The vast majority of disease is due to complex relationships between genetic and environmental factors. Single genetic or environmental causes are rare. Unfortunately, this presents major challenges for assessing disease risk in individuals. Further complicating the situation is the fact that there are many ways in which genetic and environmental determinants can combine to cause disease. This review explores the concepts of gene–environment interaction to provide a basic understanding of the principles of interactions and approaches to studying them. Collaborations between genetics and environmental experts will be crucial to understand the complex relationships.
KEYWORDS
Genetics - environment - gene–environment interaction
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Connie MarrasM.D. Ph.D.
Movement Disorders Centre, Toronto Western Hospital
399 Bathurst St.Toronto, ON M5T 2S8
Email: cmarras@uhnresearch.ca