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Synthesis 2013; 45(23): 3255-3258
DOI: 10.1055/s-0033-1338532
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© Georg Thieme Verlag Stuttgart · New York

Green, Catalyst-Free Synthesis of Mesalazine Conjugates

Mohamed A. Ibrahim
a   Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
b   Department of Organic Chemistry, College of Pharmacy, Misr University for Science and Technology, P. O. Box 77, Al-Motamayez District, Egypt
,
Siva S. Panda
a   Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
,
Khalid A. Alamry
c   Chemistry Department, King Abdulaziz University, Jeddah, 21589, Saudi Arabia   Fax: +1(352)3929199   Email: katritzky@chem.ufl.edu
,
Alan R. Katritzky*
a   Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
c   Chemistry Department, King Abdulaziz University, Jeddah, 21589, Saudi Arabia   Fax: +1(352)3929199   Email: katritzky@chem.ufl.edu
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Further Information

Publication History

Received: 12 July 2013

Accepted after revision: 22 August 2013

Publication Date:
26 September 2013 (online)

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Abstract

A greener protocol for the synthesis of mesalazine conjugates is reported. Mesalazine conjugates are prepared in high yields by a one-pot reaction of mesalazine and aminoacyl/peptidoylbenzotriazoles in water under microwave irradiation.

Key words

mesalazine - amino acid - prodrug - green chemistry - benzotriazole methodology

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    for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
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