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Synthesis 2014; 46(17): 2362-2370
DOI: 10.1055/s-0033-1339137
DOI: 10.1055/s-0033-1339137
paper
Synthesis of 1,2,3-Triazole-Linked Glycoconjugates of N-(2-Aminoethyl)glycine: Building Blocks for the Construction of Combinatorial Glycopeptide Libraries
Further Information
Publication History
Received: 20 March 2014
Accepted after revision: 24 April 2014
Publication Date:
12 June 2014 (online)
![](https://www.thieme-connect.de/media/synthesis/201417/lookinside/thumbnails/10.1055-s-0033-1339137-1.jpg)
Abstract
Twenty-nine glycoconjugate building blocks based on the N-(2-aminoethyl)glycine (AEG) backbone and sugars linked to the backbone by a 1,2,3-triazole moiety were prepared via copper-catalyzed 1,3-dipolar cycloaddition of monosaccharides bearing an azide group and N-4-pentynoyl-AEG. The initial glycoconjugates were converted to the corresponding acids and pentafluorophenyl esters, respectively, which are useful building blocks for the construction of combinatorial glycopeptide libraries.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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