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Synthesis 2013; 45(24): 3383-3386
DOI: 10.1055/s-0033-1339901
DOI: 10.1055/s-0033-1339901
paper
A Non-infringing Route for Enantioselective Synthesis of Antiepileptic Agent Lacosamide
Further Information
Publication History
Received: 29 July 2013
Accepted: 11 September 2013
Publication Date:
02 October 2013 (online)
Abstract
A non-infringing route for enantioselective synthesis of lacosamide has been developed. The synthesis started from commercially available acrylic acid and was completed in eight steps using Sharpless asymmetric dihydroxylation as a key step with an overall yield of 29%. All the reactions were very clean with good yields.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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