Synthesis 2013; 45(24): 3383-3386
DOI: 10.1055/s-0033-1339901
paper
© Georg Thieme Verlag Stuttgart · New York

A Non-infringing Route for Enantioselective Synthesis of Antiepileptic Agent Lacosamide

Sachin B. Wadavrao
Organic and Biomolecular Chemistry Division, Indian Institute of Chemical Technology, Hyderabad, 500007, India   Fax: +91(40)27160387   Email: vnakkirala2001@yahoo.com
,
Ashritha Narikimalli
Organic and Biomolecular Chemistry Division, Indian Institute of Chemical Technology, Hyderabad, 500007, India   Fax: +91(40)27160387   Email: vnakkirala2001@yahoo.com
,
A. Venkat Narsaiah*
Organic and Biomolecular Chemistry Division, Indian Institute of Chemical Technology, Hyderabad, 500007, India   Fax: +91(40)27160387   Email: vnakkirala2001@yahoo.com
› Author Affiliations
Further Information

Publication History

Received: 29 July 2013

Accepted: 11 September 2013

Publication Date:
02 October 2013 (online)


Abstract

A non-infringing route for enantioselective synthesis of lacosamide has been developed. The synthesis started from commercially available acrylic acid and was completed in eight steps using Sharpless asymmetric dihydroxylation as a key step with an overall yield of 29%. All the reactions were very clean with good yields.

Supporting Information

 
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