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Thromb Haemost 1965; 13(01): 136-139
DOI: 10.1055/s-0038-1656292
Originalarbeiten — Original Articles — Travaux Originaux
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Platelet Changes after Adrenaline Infusions with and without Adrenaline Blockers

P. D McClure   *
1   Department of Haematology, Louis Jenner Laboratories, St. Thomas’s Hospital and Medical School, London, S.E. I.
,
G. I. C Ingram
1   Department of Haematology, Louis Jenner Laboratories, St. Thomas’s Hospital and Medical School, London, S.E. I.
,
R Vaughan Jones
1   Department of Haematology, Louis Jenner Laboratories, St. Thomas’s Hospital and Medical School, London, S.E. I.
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Publication History

Publication Date:
27 June 2018 (online)

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Summary

Adrenaline infusions into young, healthy, male subjects produced a rise in both platelet counts and platelet adhesiveness. Pronethalol, a ß-blocker of adrenaline, blocked these changes. Phentolamine, an α-blocker, produced a fall in platelet count which interfered with the interpretation of its blocking effect. The results suggested however, that Phentolamine did not prevent the increase in platelet adhesiveness produced by adrenaline.

* R. Samuel McLaughlin Travelling Fellow. Present address: Hospital for Sick Children, Toronto 2, Ontario, Canada.


 

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