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Synthesis
DOI: 10.1055/s-0043-1773506
DOI: 10.1055/s-0043-1773506
paper
Efficient Synthesis of the 6-Deoxy-l-talose-Containing Pentasaccharide Corresponding to the Cell Wall O-Polysaccharide of Escherichia coli O66
P.B. thanks the University Grants Commission (UGC), India for providing a junior research fellowship. S.S. thanks the Maulana Azad National Fellowship Scheme (MANF), India for providing a senior research fellowship. This work was supported by the Bose Institute (Department of Science and Technology, India) (A.K.M.).
Abstract
The pentasaccharide repeating unit containing 6-deoxy-l-talose corresponding to the cell wall O-polysaccharide of Escherichia coli (E. coli) O66 strain has been successfully synthesized in very good yield using sequential glycosylations of judiciously functionalized monosaccharide intermediates. Incorporation of the β-d-mannosidic linkage and 6-deoxy-α-l-talose in the pentasaccharide was achieved in excellent yield.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1773506. Included are copies of 1D and 2D NMR spectra of compounds 1 and 6–11.
- Supporting Information
Publication History
Received: 23 October 2024
Accepted after revision: 28 November 2024
Article published online:
17 December 2024
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