Synlett 1990; 1990(3): 155-157
DOI: 10.1055/s-1990-21018
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

The Seleno-Acetal Route to Side-Chain-Modified 1α-Hydroxy-Vitamin D Analogues: Synthesis of Three C23-Metabolites, Including Calcitroic Acid

Martin J. Calverley*
  • *Leo Pharmaceutical Products, DK-2750 Ballerup, Denmark
Further Information

Publication History

Publication Date:
08 March 2002 (online)

A synthesis of (1α,3β,5Z,7E)-1,3-dihydroxy-24-nor-9,10-secochola-5,7,10(19)-trien-23-al and the corresponding 23-carbinol and 23-carboxylic acid (calcitroic acid) from a 1α-hydroxy-vitamin D synthon containing a seleno-acetal function for the side-chain elaboration is reported.