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Synlett 1991; 1991(5): 319-320
DOI: 10.1055/s-1991-34730
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A Facile Synthesis of (S,S)-(+)-and (R,R)-(-)-2,5-Bis(methoxymethy)pyrrolidine

Yukio Yamamoto* , Hideki Ohmori, Seiji Sawada
  • *Department of Chemistry, College of Liberal Arts and Sciences, Kyoto University, Yoshida, Kyoto 606, Japan
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Publication Date:
07 March 2002 (online)

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By the use of (S)-(-)-1-phenylethylamine as a chiral auxiliary as well as a nitrogen atom donor, (S,S)-(+)- and (R,R)-(-)-2,5- bis(methoxymethyl)pyrrolidine were synthesized from dimethyl meso-2,5-dibromoadipate through a short reaction sequence including stereoselective hydrolysis and chromatographic separation of intermediary diastereoisomers.