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Synlett 1995; 1995(1): 29-31
DOI: 10.1055/s-1995-4878
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Asymmetric Addition Reaction to Non-Prochiral Carbonyl Compound: Asymmetric Catalytic Formaldehyde-Ene Reaction for Isocarbacyclin Synthesis

Koichi Mikami* , Akihiro Yoshida
  • *Department of Chemical Technology, Tokyo Institute of Technology, Meguro-ku, Tokyo 152, Japan
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Publication Date:
31 December 2000 (online)

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Asymmetric catalysis of ene-type carbonyl addition to achiral/non-prochiral formaldehyde with the homotopic faces is described to provide a new route to the asymmetric synthesis of isocarbacyclin and 3-oxa analogues.

formaldehyde - carbonyl-ene reaction - asymmetric catalyst - double asymmetric induction - isocarbacyclins