Download PDF
Synlett 1995; 1995(9): 915-917
DOI: 10.1055/s-1995-5144
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Asymmetric Radical Cyclization Induced by a Matched Pair of Chiral Auxiliaries: Synthesis of a Chiral 1β-Methylcarbapenem Key Intermediate

Hiroyuki Ishibashi* , Chisato Kameoka, Kazuya Kodama, Masazumi Ikeda1
  • *Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607, Japan
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

The chiral 1β-methylcarbapenem key intermediate 1 was synthesized using an asymmetric radical cyclization of N-vinylic α-bromo amide 16 bearing a matched pair of chiral auxiliaries as a key step.

asymmetric induction - 1β-methylcarbapenem - Mitsunobu reaction - radical cyclization - ruthenium tetroxide oxidation