Download PDF
Synlett 1997; 1997(12): 1453-1455
DOI: 10.1055/s-1997-1061
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Enantioselective Synthesis of Novel Enantiopure Phosphines via Reaction of a Tricarbonyl(η6-arene)chromium Complex with a Chiral Lithium Amide Base

Azhar Ariffin, Alexander J. Blake, Wan-Sheung Li, Nigel S. Simpkins*
  • *Department of Chemistry, The University of Nottingham, University Park, Nottingham, NG7 2RD, UK, Fax (0115) 9513564; e-mail Nigel.Simpkins@ Nottingham.ac.uk
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

A range of novel phosphorus-containing tricarbonyl(η6-arene)chromium complexes has been synthesised via the enantioselective ortho-metallation approach using a chiral lithium amide base. Initial asymmetric reaction of a phosphine oxide complex allows the preparation of silyl- or stannyl-substituted products in ca. 73% ee, which then allows the preparation of other phosphine derivatives in very high ee (>95%) following phosphine reduction and enantiomeric enrichment.

tricarbonyl(η6-arene)chromium complex - phosphine - chiral lithium amide base