Download PDF
Synlett 1997; 1997(9): 1108-1110
DOI: 10.1055/s-1997-1527
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Transition Metal Complexes in Organic Synthesis, Part 39. First Total Synthesis of the Potent Neuronal Cell Protecting Substance (±)-Carquinostatin A via Iron- and Nickel-Mediated Coupling Reactions

Hans-Joachim Knölker* , Wolfgang Fröhner
  • *Institut für Organische Chemie, Universität Karlsruhe, Richard-Willstätter-Allee, D-76131 Karlsruhe, Germany, Fax: +49(721)698-529; E-mail: knoe@ochhades.chemie.uni-karlsruhe.de
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

The first total synthesis of the potent neuronal cell protecting carbazole alkaloid (±)-carquinostatin A was achieved by using an iron-mediated construction of the carbazole framework and a regioselective nickel-mediated prenylation as the key-steps.

carbazole alkaloids - tricarbonyliron-diene complexes - electrophilic aromatic substitution - oxidative cyclization - nickel-mediated prenylation