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Synlett 1997; 1997(9): 1053-1054
DOI: 10.1055/s-1997-1535
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A Short and Concise Synthesis of Guanidines

K. Ramadas* , N. Janarthanan, R. Pritha
  • *Centre for Agrochemical Research, SPIC Science Foundation, 110, Mount Road, Guindy, MADRAS 600 032, INDIA, FAX (044) 235 2163; e-mail: sb@biotechn.ssf.ernet.in
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Publication History

Publication Date:
31 December 2000 (online)

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A facile high yielding process of guanidines is reported by reaction of amine nucleophiles on the oxidised thioureas in an aqueous medium using the unexploited reagents sodium chlorite and sodium metaperiodate for the oxidation of 1,3-disubstituted thioureas.

substituted thioureas - oxidation - amines - displacement - guanidines