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Synlett 1997; 1997(7): 824-826
DOI: 10.1055/s-1997-5757
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Towards a Synthesis of Epothilone A: Rapid Assembly of the C1-C6 and C7-C12 Fragments

Jef De Brabander* , Stephane Rosset, Gérald Bernardinelli
  • *Département de Chimie Organique, Université de Genève, CH-1211 Genève, Switzerland, Fax 41 22 328 7396; e-mail Jef.DeBrabander@chiorg.unige.ch
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Publication Date:
31 December 2000 (online)

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A very short 4-step synthesis of the C1-C6 and C7-C12 fragments 3 and 4 of epothilone A (1a), starting from bornane-10,2-sultam 5, was achieved in 77% and 56% overall yield respectively.

epothilone - taxol - microtubules - acetate-aldol - bornanesultam

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