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Synlett 1997; 1997(7): 859-861
DOI: 10.1055/s-1997-5773
DOI: 10.1055/s-1997-5773
letter
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The Synthesis of N,N'-O-Trisubstituted Hydroxylamines via a Mild Reductive Alkylation Procedure: An Improved Synthesis of the MMI Backbone
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Publication History
Publication Date:
31 December 2000 (online)
A mild procedure for the synthesis of N,N',O-trisubstituted hydroxylamines via the reductive alkylation of N,O-disubstituted hydroxylamines with both aldehydes and ketones has been developed. We have applied this reaction to the synthesis of methylene(methylimino) (MMI) linked dimeric nucleosides, which are of potential use in antisense applications.
reductive alkylation - hydroxylamine - nucleoside - MMI - antisense