Download PDF
Synlett 1997; 1997(4): 398-400
DOI: 10.1055/s-1997-797
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Oxidative Radical-mediated Transannulation Reactions Directed Towards Polycycle Constructions

Philip Jones, Gerald Pattenden*
  • *Department of Chemistry, Nottingham University, Nottingham NG7 2RD, England
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

Oxidative radical-mediated transannular cyclisation of the macrocyclic β-ketoester 5 using Mn(OAc)3-Cu(OAc)2, leads to (9; 40%) by way of a 1,5-hydrogen abstraction pathway. In a similar manner 11 produces 12, but the positional isomer 15 undergoes a double transannular cyclisation giving the tricycle 16 albeit in only 8% yield.

transannulation - oxidative radical cyclisation - polycycle constructions

      >