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Synlett 1999; 1999(5): 549-550
DOI: 10.1055/s-1999-2684
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Low Temperature Sonogashira Coupling Reaction

Keiichi Nakamura* , Hitoshi Okubo, Masahiko Yamaguchi
  • *Faculty of Pharmaceutical Sciences, Tohoku University, Aoba, Sendai 980-8578, Japan; Fax +81(22)2 17 68 11; E-mail: yama@mail.pharm.tohoku.ac.jp
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Publication History

Publication Date:
31 December 1999 (online)

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A low temperature Sonogashira reaction was developed, which coupled equimolar amount of aryl iodide possessing electron-withdrawing groups with aromatic acetylene at - 20 °C in quantitative yield.

Sonogashira coupling reaction - n-Bu4NI - tris(2,4,6-trimethylphenyl)phosphine - aryl iodide