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Synlett 2000; 2000(10): 1515-1518
DOI: 10.1055/s-2000-7640
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Metal Templated Cyclooligomerisation of Modified Amino Acids

Alexander J. Blake* , Jeffery S. Hannam, Katrina A. Jolliffe, Gerald Pattenden
  • *School of Chemistry, University of Nottingham, Nottingham, UK, NG7 2RD; Fax + 44 (0) 115951 3564; E-mail: gp@nottingham.ac.uk
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Publication Date:
31 December 2000 (online)

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Cyclooligomerisation of the amino acid thiazole 3 is influenced by metal ions, with smaller alkali metal ions favouring the formation of the trimer 4, and larger metal ions (eg Cd2+) enhancing the formation of the tetramer 5. A crystalline complex obtained between the tetramer 5 and Ag BF4 is shown by X-ray studies to comprise two macrocycles and five silver ions in a `sandwich' type arrangement.

cyclopeptides - metal complexation