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Synlett 2001; 2001(8): 1296-1298
DOI: 10.1055/s-2001-16043
DOI: 10.1055/s-2001-16043
letter
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An Efficient and Fast Procedure for the Hantzsch Dihydropyridine Synthesis under Microwave Conditions
Further Information
Publication History
Publication Date:
31 December 2001 (online)
![](https://www.thieme-connect.de/media/synlett/200108/lookinside/thumbnails/10.1055-s-2001-16043-1.jpg)
A single-mode microwave cavity synthesizer with temperature and pressure control was used to accelerate the Hantzsch synthesis of 4-aryl and 4-alkyl-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylates. In comparison with both conventional methods and microwave-assisted reactions performed in a domestic microwave oven, shorter reaction times and higher yields were obtained. The improved yields under microwave conditions made it possible to synthesize a small library, with acceptable purity.
microwave - multicomponent reaction - temperature control - combinatorial synthesis