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Semin Plast Surg 2003; 17(1): 089-098
DOI: 10.1055/s-2003-39859
Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Tissue Engineering

Michael J. Miller, Gregory N. Bancroft, Charles W. Patrick, Jr.
  • Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX
Further Information

Publication History

Publication Date:
16 June 2003 (online)

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ABSTRACT

Tissue engineering is an interdisciplinary field promising new methods of tissue repair. There has been greater than $3.5 billion investment in this field since 1990. Relevant areas of progress include advanced computing, biomaterials, cell technology, growth factor fabrication and delivery, and gene manipulation. Techniques that are developed through basic research must be scaled up to industry to yield products that pass standards for safety and efficacy and are accepted by clinicians and patients. A goal of tissue engineering is to change clinical practice, yielding improved patient outcomes and lower costs of care.

KEYWORDS

Tissue engineering - biomaterials - growth factor - bioengineering

REFERENCES

  • 1 Langer R, Vancanti J P. Tissue engineering.  Science . 1993;  260 920-926
    CrossrefPubMedGoogle Scholar
  • 2 Griffith L G, Naughton G. Tissue engineering-current challenges and expanding opportunities.  Science . 2002;  295 1009-1014
    CrossrefPubMedGoogle Scholar
  • 3 Lalan S, Pomerantseva I, Vacanti J P. Tissue engineering and its potential impact on surgery (review).  World J Surg . 2001;  25 1458-1466
    CrossrefPubMedGoogle Scholar
  • 4 Nasseri B A, Ogawa K, Vacanti J P. Tissue engineering: an evolving 21st-century science to provide biologic replacement for reconstructive and transplantation (review).  Surgery . 2001;  130 781-784
    CrossrefPubMedGoogle Scholar
  • 5 Patrick Jr C W, Evans G RD. Tissue engineering applied to cancer plastic and reconstructive surgery. In: Ikoda Y, Yamoaka Y, eds. The Proceedings of the First International Symposium of Tissue Engineering for Therapeutic Use. Elsevier Science 1998: 97-110
    Google Scholar
  • 6 Hench L L, Polak J M. Third-generation biomedical materials (review).  Science . 2002;  295 1014-1017
    CrossrefPubMedGoogle Scholar
  • 7 Vacanti C A, Upton J. Tissue-engineered morphogenesis on cartilage and bone by means of cell transplantation using synthetic biodegradable polymer matrices (review).  Clin Plast Surg . 1994;  21 445-462
    PubMedGoogle Scholar
  • 8 Lysaght M J, Reyes J. The growth of tissue engineering (review).  Tissue Eng . 2001;  7 485-493
    CrossrefPubMedGoogle Scholar
  • 9 Mulder M M, Hitchcock R W, Tresco P A. Skeletal myogenesis on elastomeric substrates: implications for tissue engineering.  J Biomater Sci Polym Ed . 1998;  9 731-748
    PubMedGoogle Scholar
  • 10 Hendee W R, Chien S, Maynard C D. The National Institute of Biomedical Imaging and Bioengineering: history, status, and potential impact.  Ann Biomed Eng . 2002;  30 2-10
    CrossrefPubMedGoogle Scholar
  • 11 Salyer K E, Johns D F, Holmes R E. Evolution of the mandibular mesh implant.  J Biomed Mater Res . 1977;  11 461-470
    PubMedGoogle Scholar
  • 12 DiGioia A M, Jaramaz B, Colgan B D. Computer-assisted orthopedic surgery: image-guided and robotic assistive technologies.  Clin Orthop . 1998;  354 8-16
    PubMedGoogle Scholar
  • 13 Altobelli D E, Kikinis R, Mulliken J B. Computer-assisted three-dimensional planning in craniofacial surgery.  Plast Reconstr Surg . 1993;  92 576-585
    CrossrefPubMedGoogle Scholar
  • 14 Freysinger W, Gunkel A R, Bale R. Three-dimensional navigation in otorhinolaryngolgocial surgery with the viewing wand.  Ann Otol Rhinol Laryngol . 1998;  107 953-958
    PubMedGoogle Scholar
  • 15 Sodian R, Hoerstrup S P, Sperling J S. Evaluation of biodegradable, three-dimensional matrices for tissue engineering of heart valves.  ASAIO J . 2000;  46 107-110
    CrossrefPubMedGoogle Scholar
  • 16 Hollister S J, Levy R A, Chu T M. An image-based approach for designing and manufacturing craniofacial scaffolds.  Int J Oral Maxillofac Surg . 2000;  29 67-71
    CrossrefPubMedGoogle Scholar
  • 17 Salyapongse A N, Billiar T R, Edington H. Gene therapy and tissue engineering.  Clin Plast Surg . 1999;  26 663-676
    PubMedGoogle Scholar
  • 18 Miller M J, Goldberg D, Yasko A. Guided bone growth in sheep: a model for tissue-engineered bone flaps.  Tissue Eng . 1996;  2 51-59
    PubMedGoogle Scholar
  • 19 Temenoff J S, Mikos A G. Review: tissue engineering for regeneration of articular cartilage.  Biomaterials . 2000;  21 431-440
    CrossrefPubMedGoogle Scholar
  • 20 Prockop D J. Marrow stromal cells as stem cells for nonhematopoietic tissues.  Science . 1997;  76 71-74
    PubMedGoogle Scholar
  • 21 Schoen F J, Levy R J. Founder's Award, 25th Annual Meeting of the Society for Biomaterials, perspectives. Providence, RI, April 28-May 2, 1999. Tissue heart valves: current challenges and future research perspectives.  J Biomed Mater Res . 1999;  47 439-465
    PubMedGoogle Scholar
  • 22 Radice M, Brun P, Cortivo R. Hyaluronan-based biopolymers as delivery vehicles for bone-marrow-derived mesenchymal progenitors.  J Biomed Mater Res . 2000;  50 101-109
    PubMedGoogle Scholar
  • 23 Madihally S V, Matthew H W. Porous chitosan scaffolds for tissue engineering.  Biomaterials . 1999;  20 1133-1142
    CrossrefPubMedGoogle Scholar
  • 24 Meinhart J, Fussenegger M, Hobling W. Stabilization of fibrin-chondrocyte constructs for cartilage reconstruction.  Ann Plast Surg . 1999;  42 673-678
    PubMedGoogle Scholar
  • 25 Kropp B P, Cheng E Y. Bioengineering organs using small intestinal submucosa scaffolds: in vivo tissue-engineering technology.  J Endourol . 2000;  14 59-62
    PubMedGoogle Scholar
  • 26 van den Bos C, Mosca J D, Winleks J. Human mesenchymal stem cells respond to fibroblast growth factors.  Hum Cell . 1997;  10 45-50
    PubMedGoogle Scholar
  • 27 Peter S J, Lu L, Kim D J. Effects of transforming growth factor betal released from biodegradable polymer microparticles on marrow stromal osteoblasts cultured on poly(propylene fumarate) substrates.  J Biomed Mater Res . 2000;  50 452-462
    PubMedGoogle Scholar
  • 28 Friedman C D, Costantino P D, Takagi S. BoneSource hydroxyapatite cement: a novel biomaterial for craniofacial skeletal tissue engineering and reconstruction.  J Biomed Mater Res . 1998;  43 428-432
    CrossrefPubMedGoogle Scholar
  • 29 Yannas I V, Burke J F, Orgill D P. Wound tissue can utilize a polymeric template to synthesize a functional extension of skin.  Science . 1982;  215 174-176
    PubMedGoogle Scholar
  • 30 Pepper M, Mandriota S. Regulation of vascular endothelial growth factor receptor-2 (Flk-1) expression in vascular endothelial cells.  Exp Cell Res . 1998;  241 414-425
    CrossrefPubMedGoogle Scholar
  • 31 King T, Patrick J C. Development and in vitro characterization of vascular endothelial growth factor (VEGF)-loaded poly(DL-lactic-co-glycolic acid)/poly(ethylene glycol) microspheres using a solid encapsulation/single emulsion/solvent extraction technique.  J Biomed Mater Res . 2000;  51 383-390
    PubMedGoogle Scholar
  • 32 Kapur R, Calvert J M, Rudolph A S. Electrical, chemical, and topological addressing of mammalian cells with microfabricated systems.  J Biomech Eng . 1999;  121 65-72
    PubMedGoogle Scholar
  • 33 Myles J L, Burgess B T, Dickinson R B. Modification of the adhesive properties of collagen by covalent grafting with RGD peptides.  J Biomater Sci Polym Ed . 2000;  11 69-86
    CrossrefPubMedGoogle Scholar
  • 34 Murphy W L, Kohn D H, Mooney D J. Growth of continuous bonelike mineral within porous poly(lactide-co-glycolide) scaffolds in vitro.  J Biomed Mater Res . 2000;  50 50-58
    PubMedGoogle Scholar
  • 35 Peter S J, Miller M J, Yasko A W. Polymer concepts in tissue engineering.  J Biomed Mater Res . 1998;  43 422-427
    PubMedGoogle Scholar
  • 36 Bhadriraju K, Hansen L K. Hepatocyte adhesion, growth and differentiated function on RGD-containing proteins.  Biomaterials . 2000;  21 267-272
    CrossrefPubMedGoogle Scholar
  • 37 Chen C S, Mrksich M, Huang S. Micropatterned surfaces for control of cell shape, position, and function.  Biotechnol Prog . 1998;  14 356-363
    CrossrefPubMedGoogle Scholar
  • 38 Odde D J, Renn M J. Laser-guided direct writing for applications in biotechnology.  Trends Biotechnol . 1999;  17 385-389
    CrossrefPubMedGoogle Scholar
  • 39 Kane R S, Takayama S, Ostuni E. Patterning proteins and cells using soft lithography.  Biomaterials . 1999;  20 2363-2376
    CrossrefPubMedGoogle Scholar
  • 40 Inoue K, Ohgushi H, Yoshikawa T, Okumura M. The effect of aging on bone formation in porous hydroxyapatite. Biochemical and histological analysis.  J Bone Min Res . 1997;  12 989-994
    PubMedGoogle Scholar
  • 41 Quarto R, Thomas D, Liang T. Bone progenitor cell deficits and the age-associated decline in bone repair capacity.  Calcif Tssue Int . 1995;  56 123-129
    PubMedGoogle Scholar
  • 42 Bancroft G N, Mikos A G. Bone tissue engineering by cell transplantation. In: Ikada Y, Ohshima N, eds. Tissue Engineering for Therapeutic Use, vol 5 New York: Elsevier Science 2001: 151-163
    Google Scholar
  • 43 Thomson R C, Mikos A G, Beahm E. Guided tissue fabrication from periosteum using preformed biodegradable polymer scaffolds.  Biomaterials . 1999;  20 2007-2018
    CrossrefPubMedGoogle Scholar
  • 44 Kim W S, Vacanti C A, Upton J. Bone defect repair with tissue engineered cartilage.  Plast Reconstr Surg . 1994;  94 580-584
    PubMedGoogle Scholar
  • 45 Folkman J, Hochberg M M. Self-regulation of growth in three dimensions.  J Exp Med . 1973;  138 745-753
    CrossrefPubMedGoogle Scholar
  • 46 Ranucci C S, Kumar A, Batra S P. Control of hepatocyte function on collagen foams: sizing matrix pores toward selective induction of 2-D and 3-D cellular morphogenesis.  Biomaterials . 2000;  21 783-793
    CrossrefPubMedGoogle Scholar
  • 47 Bancroft G N, Sikavitsas V I, van den Dolder J. Fluid flow increases mineralized matrix deposition in three-dimensional perfusion culture of marrow stromal osteoblasts in a dose-dependent manner.  Proc Natl Acad Sci USA . 2002;  99 12600-12605
    CrossrefPubMedGoogle Scholar
  • 48 Goldstein A S, Juarez T M, Helmke C D, Gustin M C, Mikos A G. Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds.  Biomaterials . 2001;  11 1279-1288
    PubMedGoogle Scholar
  • 49 Bancroft G N, Sikavitsas V I, Mikos A G. Development of a flow perfusion culture system for bone tissue engineering (in press).  Tissue Eng.
    PubMedGoogle Scholar
  • 50 Klein-Nulend J, van der Plas A, Semeins C M, Ajubi N E. Sensitivity of osteocytes to biomechanical stress in vitro.  FASEB J . 1995;  9 441-445
    PubMedGoogle Scholar
  • 51 Owan I, Burr D B, Turner C H, Qiu J. Mechanotransduction in bone: osteoblasts are more responsive to fluid forces than mechanical strain.  Am J Physiol . 1997;  273 C810-C815
    PubMedGoogle Scholar
  • 52 Bancroft G N, van den Dolder J, Sikavitsas V I, Spauwen P HM. Flow perfusion culture of marrow stromal osteoblasts in titanium fiber mesh (in press).  J Biomed Mater Res.
    PubMedGoogle Scholar
  • 53 Vacanti J P, Morse M A, Saltzman W M. Selective cell transplantation using bioabsorbable artificial polymers as matrices.  J Pediatr Surg . 1988;  23 3-9
    CrossrefPubMedGoogle Scholar
  • 54 Sechriest V F, Miao Y J, Niyibizi C. GAG-augmented polysaccharide hydrogel: a novel biocompatible and biodegradable material to support chondrogenesis.  J Biomed Mater Res . 2000;  49 534-541
    PubMedGoogle Scholar
  • 55 Patrick Jr W C. Emerging technology for the new millennium: tissue engineering.  Maxillofac News . 2000;  15 1-13
    PubMedGoogle Scholar
  • 56 Weiss A, Olmedo M, Lin J. Growth factor modulation of the formation of a molded vascularized bone graft in vivo.  J Hand Surg . 1995;  20 94-100
    PubMedGoogle Scholar
  • 57 Muraglia A, Martin I, Cancedda R. A nude mouse model for human bone formation in unloaded conditions.  Bone . 1998;  22 131S-134S
    CrossrefPubMedGoogle Scholar
  • 58 Wang D, Miura M, Demura H. Anabolic effects of 1,25-dihydroxyvitamin D3 on osteoblasts are enhanced by vascular endothelial growth factor produced by osteoblasts and by growth factors produced by endothelial cells.  Endocrinology . 1997;  138 2953-2962
    CrossrefPubMedGoogle Scholar
  • 59 Wainwright D J. Use of an acellular allograft dermal matrix (AlloDerm) in the management of full-thickness burns.  Burns . 1995;  21 243-248
    CrossrefPubMedGoogle Scholar
  • 60 Rotter N, Aigner J, Naumann A. Cartilage reconstruction in head and neck surgery: comparison of resorbable polymer scaffolds for tissue engineering of human septal cartilage.  J Biomed Mater Res . 1998;  42 347-356
    CrossrefPubMedGoogle Scholar
  • 61 Kuo M D, Waugh J M, Yuksel E. 1998 ARRS President's Award. The potential of in vivo vascular tissue engineering for the treatment of vascular thrombosis: a preliminary report. American Roentgen Ray Society.  Am J Roentgenol . 1998;  171 553-558
    PubMedGoogle Scholar
  • 62 Chang T M, Prakash S. Therapeutic uses of microencapsulated genetically engineered cells (review).  Mol Med Today . 1998;  4 221-227
    PubMedGoogle Scholar
  • 63 Yannas I V, Burke J F. Design of an artificial skin: basic design principles.  Journal of Biomedical Materials Research . 1980;  14 65-81
    CrossrefPubMedGoogle Scholar
  • 64 Auger F A, Rouabhia M, Goulet F. Tissue-engineered human skin substitutes developed from collagen-populated hydrated gels: clinical and fundamental applications.  Med Biol Eng Comput . 1998;  36 801-812
    PubMedGoogle Scholar
  • 65 Katz A J, Llull R, Hedrick M H. Emerging approaches to the tissue engineering of fat.  Clin Plast Surg . 1999;  26 587-603
    PubMedGoogle Scholar
  • 66 Lee K Y, Halberstadt C R, Holder W D. Breast reconstruction. In: Lanza RP, Langer R, Vacanti J, eds. Principles of Tissue Engineering San Diego: Academic Press 2000: 409-423
    Google Scholar
  • 67 Patrick J C. Tissue engineering of fat.  Semin Surg Oncol . 2000;  19 302-311
    CrossrefPubMedGoogle Scholar
  • 68 Patrick J C. Tissue engineering strategies for soft tissue repair.  Anat Rec . 2001;  263 361-366
    CrossrefPubMedGoogle Scholar
  • 69 Patrick Jr C W, Chauvin  P B, Robb  G L. Tissue engineered adipose. In: Patrick CW Jr, Mikos AG, McIntire LV, eds. Frontier in Tissue Engineering Oxford: Elsiver Science 1998: 369-382
    Google Scholar
  • 70 Richardson D, Peters M, Ennet A. Polymeric system for dual growth factor delivery.  Nature Biotechnol . 2001;  19 1029-1034
    CrossrefPubMedGoogle Scholar
  • 71 Chen D, Kakadiaris I, Miller M. Modeling for plastic and reconstructive breast surgery. In: Delp S, DiGioia A, Jaramaz B, eds. Lecture Notes in Computer Science Berlin: Springer-Verlag 2000: 1040-1050
    Google Scholar
  • 72 Patrick J C, Chauvin P, Reece G. Preadipocyte seeded PLGA scaffolds for adipose tissue engineering.  Tissue Eng . 1999;  5 139-151
    CrossrefPubMedGoogle Scholar
  • 73 Patrick J C, Wu X, Johnston C. Epithelial cell culture: breast. In: Atala A, Lanza R, eds. Methods of Tissue Engineering San Diego: Academic Press 2001: 143-154
    Google Scholar
  • 74 Patrick J C, Zheng B, Johnston C. Long-term implantation of preadipocyte seeded PLGA scaffolds.  Tissue Eng . 2002;  8 283-293
    CrossrefPubMedGoogle Scholar
  • 75 Beahm E, Walton R. Fat Engineering: The Future of Breast Reconstruction.  Breast Diseases: A Year Book Quarterly . 2001;  12 144-147
    PubMedGoogle Scholar
  • 76 Boden S D. Bioactive factors for bone tissue engineering.  Clin Orthop. 1999;  S84-S94
    CrossrefPubMedGoogle Scholar
  • 77 Winet H, Bao J. Fibroblast growth factor-2 alters the effect of eroding polylactide-polyglycolide on osteogenesis in the bone chamber.  J Biomed Mater Res . 1998;  40 567-576
    PubMedGoogle Scholar
  • 78 Isogai N, Landis W, Kim T H. Formation of phalanges and small joints by tissue-engineering.  J Bone Joint Surg Am . 1999;  81 306-316
    CrossrefPubMedGoogle Scholar
  • 79 Evans G, Brandy K, Niederbichler A. Bioactive poly(L-latic acid) conduits seeded with Schwan cells for peripheral nerve regeneration.  Biomaterials . 2002;  23 841-848
    CrossrefPubMedGoogle Scholar
  • 80 Evans G, Brandy K, Niederbichler A. Clinical long-term in vivo evaluation of poly(L-lactic acid) porous conduits for peripheral nerve regeneration.  J Biomater Sci . 2000;  11 869-878
    PubMedGoogle Scholar
  • 81 Hudson T W, Evans G R, Schmidt C E. Engineering strategies for peripheral nerve repair.  Clin Plast Surg . 1999;  26 617-628
    PubMedGoogle Scholar
  • 82 Patrick J C, Zheng B, Schmidt M. Dermal fibroblasts genetically engineered to release NGF.  Ann Plast Surg . 2001;  47 660-665
    PubMedGoogle Scholar
  • 83 Patrick J C, Zheng B, Wu X. Muristerone A-induced nerve growth factor release from genetically engineered human dermal fibroblasts for peripheral nerve tissue engineering.  Tissue Eng . 2001;  7 303-311
    CrossrefPubMedGoogle Scholar
  • 84 Okano T, Satoh S, Oka T. Tissue engineering of skeletal muscle. Highly dense, highly oriented hybrid muscular tissues biomimicking native tissues.  ASAIO J . 1997;  43 M749-M753
    PubMedGoogle Scholar
  • 85 Brey E, King T, Johnston C. A technique for quantitative 3D analysis of microvascular networks.  Microvasc Res . 2002;  63 279-294
    PubMedGoogle Scholar
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