Synthesis 2003(14): 2221-2225  
DOI: 10.1055/s-2003-41067
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Unsymmetrical β-Enamino Ketones

Atanas P. Venkov*, Plamen A. Angelov
Department of Organic Chemistry, University of Plovdiv, 24 ‘Tsar Asen’ str., 4000 Plovdiv, Bulgaria
e-Mail: angelov@argon.acad.bg;
Further Information

Publication History

Received 21 May 2003
Publication Date:
24 September 2003 (online)

Abstract

A convenient procedure for modification of β-enaminones by α-C-acylation and subsequent acidic cleavage is described. The unsymmetrical β-enamino ketones obtained in this way could be hydrolyzed to provide an entry towards various unsymmetrical 1,3-diketones.

1

Dr Atanas Venkov passed away suddenly on July 21st, 2003, aged 62.

7

The phosphoric acid used in these experiments was obtained by adding P2O5 (39.4 g) to 85% H3PO4 (d = 1.7, 58.82 mL/100 g).