Download PDF
Dtsch Med Wochenschr 2007; 132(28/29): 1529-1533
DOI: 10.1055/s-2007-982064
Übersicht | Review article
Infektiologie, Pneumologie
© Georg Thieme Verlag KG Stuttgart · New York

Das humane Bocavirus: Erreger von Atemwegsinfektionen?

The human bocavirus: Pathogen in airway infections?S. Völz1 , O. Schildgen2 , A. Müller2 , R. L. Tillmann2 , A. M. Eis-Hübinger2 , B. Kupfer 2 , U. Bode 1 , M. L. Lentze1 , A. Simon1
  • 1Zentrum für Kinderheilkunde des Universitätsklinikums Bonn
  • 2Institut für Virologie des Universitätsklinikums Bonn
Further Information

Publication History

eingereicht: 12.3.2007

akzeptiert: 14.6.2007

Publication Date:
03 July 2007 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Das humane Bocavirus (HBoV) wurde erstmals 2005 von Allander et al. beschrieben. Es handelt sich um ein humanpathogenes Parvovirus, das weltweit verbreitet zu sein scheint und vornehmlich im Säuglings- und Kleinkindalter mit Infektionen der Atemwege assoziiert ist. Die hier vorliegende Übersicht diskutiert anhand der bis Februar 2007 publizierten Studien das HBoV aus klinischer Perspektive.

Summary

The human Bocavirus (HBoV), the second member of the parvovirus family, which displays pathogenicity in humans, has been described in 2005 by Allander et al.. It seems to be distributed worldwide and has been isolated mainly in infants and children with respiratory tract infection. This review covers all studies published on HBoV to February 2007 and discusses this emerging viral pathogen from the perspective of inpatient medical treatment centers.

Schlüsselwörter

humanes Bocavirus - Atemwegsinfektion - hospitalisierte Kinder

Key words

human Bocavirus - respiratory tract infection - hospitalized infants and children

Literatur

  • 1 Allander T, Jartti T, Gupta S. et al . Human bocavirus and acute wheezing in children.  Clin Infect Dis. 2007;  44 904-910
    Google Scholar
  • 2 Allander T, Tammi M T, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B. Cloning of a human parvovirus by molecular screening of respiratory tract samples.  Proc Natl Acad Sci U S A. 2005;  102 12891-12896
    Google Scholar
  • 3 American Academy of Pediatrics . Diagnosis and management of bronchiolitis.  Pediatrics. 2006;  118 1774-1793
    Google Scholar
  • 4 Arnold J C, Singh K K, Spector S A, Sawyer M H. Human bocavirus: prevalence and clinical spectrum at a children’s hospital.  Clin Infect Dis. 2006;  43 283-288
    Google Scholar
  • 5 Bastien N, Brandt K, Dust K, Ward D, Li Y. Human Bocavirus infection, Canada.  Emerg Infect Dis. 2006;  12 848-850
    Google Scholar
  • 6 Choi E H, Lee H J, Kim S J. et al . The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children, 2000 - 2005.  Clin Infect Dis. 2006;  43 585-592
    Google Scholar
  • 7 Donnelly L F. Imaging in immunocompetent children who have pneumonia.  Radiol Clin North Am. 2005;  43 253-265
    Google Scholar
  • 8 Donnelly L F. Practical issues concerning imaging of pulmonary infection in children.  J Thorac Imaging. 2001;  16 238-250
    Google Scholar
  • 9 Fitzgerald D A, Kilham H A. Bronchiolitis: assessment and evidence-based management.  Med J Aust. 2004;  180 399-404
    Google Scholar
  • 10 Foulongne V, Olejnik Y, Perez V, Elaerts S, Rodiere M, Segondy M. Human bocavirus in French children.  Emerg Infect Dis. 2006;  12 1251-1253
    Google Scholar
  • 11 Foulongne V, Rodiere M, Segondy M. Human Bocavirus in children.  Emerg Infect Dis. 2006;  12 862-863
    Google Scholar
  • 12 Fry A M, Lu X, Chittaganpitch M. et al . Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand.  J Infect Dis. 2007;  195 1038-1045
    Google Scholar
  • 13 Kaplan N, Dove W, Abu-Zeid A. et al . Human Bocavirus Infection among Children, Jordan.  Emerg Infect Dis. 2006;  12 1419-1420
    Google Scholar
  • 14 Kesebir D, Vazquez M, Weibel C. et al . Human bocavirus infection in young children in the United States: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus.  J Infect Dis. 2006;  194 1276-1282
    Google Scholar
  • 15 Kleines M, Scheithauer S, Rackowitz A, Ritter K, Hausler M. High prevalence of human bocavirus detected in young children with severe acute lower respiratory tract disease using a standard PCR protocol and a novel real time PCR protocol.  J Clin Microbiol. 2007;  45 (3) 1032-1034
    Google Scholar
  • 16 Korppi M. Community-acquired pneumonia in children: issues in optimizing antibacterial treatment.  Paediatr Drugs. 2003;  5 821-832
    Google Scholar
  • 17 Korppi M. Mixed microbial aetiology of community-acquired pneumonia in children.  Apmis. 2002;  110 515-522
    Google Scholar
  • 18 Kupfer B, Vehreschild J, Cornely O. et al . Severe Pneumonia and Human Bocavirus in an Adult.  Emerg Infect Dis. 2006;  12 1614-1616
    Google Scholar
  • 19 Lin F, Zeng A, Yang N. et al . Quantification of human bocavirus in lower respiratory tract infections in China.  Infect Agent Cancer. 2007;  2 3
    Google Scholar
  • 20 Lu X, Chittaganpitch M, Olsen S J. et al . Real-time PCR assays for detection of bocavirus in human specimens.  J Clin Microbiol. 2006;  44 3231-3235
    Google Scholar
  • 21 Ma X, Endo R, Ishiguro N. et al . Detection of human bocavirus in Japanese children with lower respiratory tract infections.  J Clin Microbiol. 2006;  44 1132-1134
    Google Scholar
  • 22 Manning A, Russell V, Eastick K. et al . Epidemiological profile and clinical associations of human bocavirus and other human parvoviruses.  J Infect Dis. 2006;  194 1283-1290
    Google Scholar
  • 23 McIntosh K. Community-acquired pneumonia in children.  N Engl J Med. 2002;  346 429-437
    Google Scholar
  • 24 Meissner H C. Selected populations at increased risk from respiratory syncytial virus infection.  Pediatr Infect Dis J. 2003;  22 S40-4; discussion S44 - 45
    Google Scholar
  • 25 Ogra P L. Respiratory syncytial virus: the virus, the disease and the immune response.  Paediatr Respir Rev. 2004;  (Suppl A) 5 S119-126
    Google Scholar
  • 26 Openshaw P J, Tregoning J S. Immune responses and disease enhancement during respiratory syncytial virus infection.  Clin Microbiol Rev. 2005;  18 541-555
    Google Scholar
  • 27 Panitch H B. Viral respiratory infections in children with technology dependence and neuromuscular disorders.  Pediatr Infect Dis J. 2004;  23 S222-227
    Google Scholar
  • 28 Regamey N, Frey U, Deffernez C, Latzin P, Kaiser L. Isolation of human Bocavirus from Swiss infants with respiratory infections.  Pediatr Infect Dis J. 2007;  26 177-179
    Google Scholar
  • 29 Schenk T, Huck B, Forster J, Berner R, Neumann-Haefelin D, Falcone V. Human bocavirus DNA detected by quantitative real-time PCR in two children hospitalized for lower respiratory tract infection.  Eur J Clin Microbiol Infect Dis. 2007;  26 147-149
    Google Scholar
  • 30 Simoes E A. Environmental and demographic risk factors for respiratory syncytial virus lower respiratory tract disease.  J Pediatr. 2003;  143 S118-126
    Google Scholar
  • 31 Simon A, Groneck P, Kupfer B. et al . Detection of bocavirus DNA in nasopharyngeal aspirates of a child with bronchiolitis.  J Infect. 2007;  54 e125-127
    Google Scholar
  • 32 Simon A, Khurana K, Wilkesmann A. et al . Nosocomial respiratory syncytial virus infection: Impact of prospective surveillance and targeted infection control.  Int J Hyg Environ Health. 2006;  209 317-324
    Google Scholar
  • 33 Sloots T P, McErlean P, Speicher D J, Arden K E, Nissen M D, Mackay I M. Evidence of human coronavirus HKU1 and human bocavirus in Australian children.  J Clin Virol. 2006;  35 99-102
    Google Scholar
  • 34 Smuts H, Hardie D. Human Bocavirus in hospitalized children, South Africa.  Emerg Infect Dis. 2006;  12 1457-1458
    Google Scholar
  • 35 Smyth R L, Openshaw P J. Bronchiolitis.  Lancet. 2006;  368 312-322
    Google Scholar
  • 36 Völz S, Schildgen O, Klinkenberg D. et al . Prospective study of human Bocavirus (HBoV) infection in a pediatric university hospital in Germany 2005/2006.  J Clin Virol. 2007;  submitted
    Google Scholar
  • 37 Weigl J A, Puppe W, Schmitt H J. Can respiratory syncytial virus etiology be diagnosed clinically? A hospital-based case-control study in children under two years of age.  Eur J Epidemiol. 2003;  18 431-439
    Google Scholar
  • 38 Weissbrich B, Neske F, Schubert J. et al . Frequent detection of bocavirus DNA in German children with respiratory tract infections.  BMC Infect Dis. 2006;  6 109
    Google Scholar
  • 39 Wilkesmann A, Schildgen O, Eis-Hubinger A M. et al . Human metapneumovirus infections cause similar symptoms and clinical severity as respiratory syncytial virus infections.  Eur J Pediatr. 2006;  165 467-475
    Google Scholar
  • 40 Wilkesmann A, Schildgen O, Eis-Hubinger A M, Lentze M J, Bode U, Simon A. Das humane Metapneumovirus als Erreger von Atemwegsinfektionen bei hospitalisierten Kindern - eine Übersicht.  Klin Padiatr. 2007;  219 (2) 58-65
    Google Scholar
  • 41 Williams J V, Harris P A, Tollefson S J. et al . Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children.  N Engl J Med. 2004;  350 443-450
    Google Scholar

Priv.-Doz. Dr. rer. nat. Oliver Schildgen

Institut für Virologie

Sigmund-Freud-Straße 25

53105 Bonn

Phone: 0228/28711697

Fax: 0228/28714433

Email: schildgen@mibi03.meb.uni-bonn.de

      >