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Synlett 2008(15): 2283-2286  
DOI: 10.1055/s-2008-1078278
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Regioselective Preparation of N-Methylpyrazole Derivative

Roberto Profeta, Mario Mattioli, Fabrizio Micheli, Elisa Piga, Simone Spada, Luca Tarsi, Daniele Andreotti*
GlaxoSmithKline, Medicine Research Centre, Via A Fleming 4, 37135 Verona, Italy
Fax: +39(045)8218196; e-Mail: daniele.g.andreotti@GSK.com;
Further Information

Publication History

Received 26 May 2008
Publication Date:
21 August 2008 (online)

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Abstract

A novel high-yielding and regioselective method to prepare N-methylpyrazole derivative is reported, by reaction of an N-Boc- and N-Me-substituted hydrazone with an aromatic alkyl ester.

Key words

hydrazones - regioselectivity - cyclizations - pyrazoles

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