Arenophile-Mediated Dearomative Functionalization Strategies

Abstract

The dearomatization of arenes is a fundamental synthetic strategy, providing a direct connection between simple hydrocarbons and valuable, more complex intermediates. While several strategies exist, the functionalization with concurrent introduction of functionality (i.e., dearomative functionalization) is still a largely underdeveloped field. This Synpacts article provides an overview and insights from our recent work in this area using small molecules—arenophiles.

1 Introduction

2 Arenophiles

3 Olefin-Like Dearomative Functionalizations

4 Arenophiles and Transition-Metal Catalysis

5 Applications in Natural Product Synthesis

6 Conclusion

Key words

arenes - dearomatization - functionalization - natural products - cycloaddition - catalysis - carbocycles

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