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Synlett 2023; 34(17): 2005-2010
DOI: 10.1055/a-2109-0183
DOI: 10.1055/a-2109-0183
letter
Ruthenium(II)-Catalyzed C–H Annulation of Mandelic Acids with Internal Alkynes to Construct Isocoumarins
This work was financially supported by the Natural Science Foundation of Guangxi (project no. 2020GXNSFAA159125) and by the Science Foundation of Yulin Normal University (project no. G2019ZK17).
Abstract
A series of isocoumarins were synthesized by a one-pot cyclization reaction with mandelic acids and internal alkynes as raw materials, [RuCl2(p-cymene)]2 as a catalyst, and Cu(OAc)2·H2O as an oxidant under reflux conditions in air. By using the established efficient and reliable reaction conditions, a range of substrates were explored, and it was found that both aromatic aldehydes and aromatic acids also reacted smoothly in this system to give moderate yields of the target products. Furthermore, the mandelic acids were shown to be converted into the corresponding benzoic acids as intermediates in the reaction.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2109-0183.
- Supporting Information
Publikationsverlauf
Eingereicht: 04. Mai 2023
Angenommen nach Revision: 12. Juni 2023
Accepted Manuscript online:
12. Juni 2023
Artikel online veröffentlicht:
21. August 2023
© 2023. Thieme. All rights reserved
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