Scandium(III) Triflate Catalyzed Reductive Etherification of Carbonyl Compounds with Alcohols Using 1,1,3,3-Tetramethyldisiloxane as the Reducing Agent

Abstract

In this study, we present a straightforward protocol for the reductive etherification of carbonyl compounds with alcohols using a catalytic amount of scandium(III) triflate [Sc(OTf)₃] and 1,1,3,3-tetramethyldisiloxane to produce nonsymmetrical ethers. The reaction proceeds under mild room-temperature conditions and accommodates a broad range of substrates, including α,β-unsaturated aldehydes, yielding the desired products in good to excellent yields. Notably, the catalyst loading of Sc(OTf)₃ could be reduced to 0.1 mol%.

Key words

reduction - etherification - carbonyl compounds - ethers - scandium triflate catalysis - hydrosilanes

Publikationsverlauf

Eingereicht: 28. Oktober 2024

Angenommen nach Revision: 29. November 2024

Accepted Manuscript online:
29. November 2024

Artikel online veröffentlicht:
16. Januar 2025

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