Scandium(III) Triflate Catalyzed Reductive Etherification of Carbonyl Compounds with Alcohols Using 1,1,3,3-Tetramethyldisiloxane as the Reducing Agent

Abstract

In this study, we present a straightforward protocol for the reductive etherification of carbonyl compounds with alcohols using a catalytic amount of scandium(III) triflate [Sc(OTf)₃] and 1,1,3,3-tetramethyldisiloxane to produce nonsymmetrical ethers. The reaction proceeds under mild room-temperature conditions and accommodates a broad range of substrates, including α,β-unsaturated aldehydes, yielding the desired products in good to excellent yields. Notably, the catalyst loading of Sc(OTf)₃ could be reduced to 0.1 mol%.

Key words

reduction - etherification - carbonyl compounds - ethers - scandium triflate catalysis - hydrosilanes

Publication History

Received: 28 October 2024

Accepted after revision: 29 November 2024

Accepted Manuscript online:
29 November 2024

Article published online:
16 January 2025

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