Synlett 2025; 36(06): 651-660
DOI: 10.1055/a-2493-8106
account

Synthesis of Chiral Cyclopentadienyl Rhodium Complexes and Their Application in Enantioselective C–H Functionalization Reactions

Bo-Bo Gou
,
Wen-Jie Shen
,
Qing Gu
,
Shu-Li You
We thank the National Key R&D Program of China (2021YFA1500100), the National Natural Science Foundation of China (21821002, 92256302 and 22071260) for generous financial support. S.-L.Y. acknowledges the support from New Cornerstone Science Foundation.


Abstract

In recent years, rhodium catalysis has evolved as a powerful tool for chemo- and stereocontrolled syntheses of chiral molecules through C–H functionalization. In particular, chiral cyclopentadienyl rhodium (CpRh) complex-catalyzed asymmetric C–H functionalization reactions have gained ever-increasing attention in organic synthesis. However, the design and synthesis of novel chiral Cp ligands remain challenging due to the difficulty of imparting chiral elements into the Cp moiety. In this account, we introduce our research progress in the syntheses of chiral cyclopentadienyl ligands and their applications in rhodium-catalyzed asymmetric C–H functionalization reactions.

1 Introduction

2 SCpRh-Catalyzed Enantioselective C–H Functionalization Reactions

3 CpmRh-Catalyzed Enantioselective C–H Functionalization Reactions

4 BOCpRh-Catalyzed Enantioselective C–H Functionalization Reactions

5 BCSCpRh-Catalyzed Enantioselective C–H Functionalization Reactions

6 Conclusion



Publikationsverlauf

Eingereicht: 06. November 2024

Angenommen nach Revision: 29. November 2024

Accepted Manuscript online:
29. November 2024

Artikel online veröffentlicht:
18. Dezember 2024

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