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Synfacts 2008(12): 1312-1312  
DOI: 10.1055/s-0028-1083588
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd-Catalyzed Carbonylation of Aryl Bromides at Atmospheric Pressure

Contributor(s): Paul Knochel, Andrei Gavryushin
J. R. Martinelli, D. A. Watson, D. M. M. Freckmann, T. E. Barder, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
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Publication History

Publication Date:
20 November 2008 (online)

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Significance

Conversion of aryl halides into carbonyl compounds can be made in an atom-economic way by using carbon monoxide. This convenient procedure allows the preparation of a large variety of substituted benzoates and benz­amides as well as their heterocyclic analogues, bearing important functional groups.