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Synfacts 2008(12): 1313-1313  
DOI: 10.1055/s-0028-1083596
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Efficient Amination of Heteroaryl and Aryl Halides Using [(CyPF-t-Bu)PdCl2]

Contributor(s): Paul Knochel, Andreas J. Wagner
Q. Shen, J. F. Hartwig*
University of Illinois Urbana-Champaign and Yale University, New Haven, USA
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Publikationsverlauf

Publikationsdatum:
20. November 2008 (online)

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Significance

[(CyPF-t-Bu)PdCl2] has been found to be a highly efficient, air- and moisture-resistant catalyst for the aminative coupling of heteroaryl chlorides, bromides and iodides to a variety of primary amines. The required catalyst loading is extremely low, most reactions give a high yield of product with 0.001-0.05 mol% of catalyst. A wide range of functional groups is tolerated in this amination reaction.