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Synfacts 2008(12): 1323-1323
DOI: 10.1055/s-0028-1083598
DOI: 10.1055/s-0028-1083598
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Sn-Free Radical Addition of Acyloxymethyl to Imines
K.-i. Yamada, M. Nakano, M. Maekawa, T. Akindele, K. Tomioka*
Kyoto University, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. November 2008 (online)
Significance
Iodomethyl esters were converted into the corresponding acyloxymethyl radicals and successfully underwent addition to the C=N bond of various protected imines. The resulting aminoethyl esters are then readily cleaved by KOH yielding N,2-disubstituted 2-aminoethanol derivatives.